Página 15 dos resultados de 1096 itens digitais encontrados em 0.012 segundos

## Herramientas de software para OAI-PMH

Bueno-de-la-Fuente, Gema; Rodríguez-Mateos, David
Fonte: Rojas Eberhard (Colombia) Publicador: Rojas Eberhard (Colombia)
Tipo: Parte de Livro Formato: application/pdf
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Tanto para poner en marcha proveedores de datos como proveedores de servicios o agregadores, es importante conocer cuáles son las alternativas de software entre las que elegir. Aunque en los capítulos anteriores se dan algunas indicaciones, se ha considerado oportuno dedicar el capítulo 8, “Herramientas de software para OAI-PMH”, a elaborar una descripción de las principales aplicaciones empleadas en la actualidad. Tras una primera introducción sobre la diferencia entre software libre, software de código abierto y software propietarios, se muestran las principales herramientas de software libre empleadas para la creación de repositorios, la generación de proveedores de datos que no son repositorios en sí, la recogida de metadatos mediante recolectores y proveedores de servicios; y, por último, otras herramientas que soportan OAI-PMH. En primer lugar, se describen las principales herramientas de software para la creación de repositorios. Básicamente, todas ellas deben cumplir algunos requisitos: Soportar el flujo documental: introducción de documentos; rechazo o aceptación de los mismos por los administradores del repositorio; edición de los -metadatos sobre los recursos, etc. Ofrecer para estas acciones diferentes niveles de acceso: usuario...

## New Workflows and Tools for ETD Support at the University of Florida

USETDA 2014 ( Conference ); Sullivan, Mark Vincent; Shorey, Christine
Fonte: USETDA 2014; USETDA 2014 Publicador: USETDA 2014; USETDA 2014
Tipo: mixed material Formato: Conference Papers
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(Acquisition) Collected for University of Florida's Institutional Repository by the UFIR Self-Submittal tool. Submitted by Mark Sullivan.; (Publication Status) Published

## Documenting the Creative Mind: ETDs in the Fine Arts and Design

Lindell, Ann; Cornwell, Robena; Caswell, Tom
Tipo: mixed material Formato: Poster
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(Acquisition) Collected for University of Florida's Institutional Repository by the UFIR Self-Submittal tool. Submitted by Ann Lindell.; (Publication Status) Unpublished; Poster session presented at the United States Electronic Thesis and Dissertation Association (USETDA) Conference, Orlando FL, May 19, 2011.

## Queen’s University E-thesis Service

Kalb, Sam
Fonte: Quens University Publicador: Quens University
Tipo: Conferência ou Objeto de Conferência
Português
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A presentation on the support services provided by the Library to Queen's University graduate students in preparing, formatting and submitting their electronic theses and dissertations. The major focus of the presentation was the ETD template service.

## An assessment on DNA microarray and sequence-based methods for the characterization of methicillin-susceptible Staphylococcus aureus from Nigeria

Shittu, Adebayo O.; Oyedara, Omotayo; Okon, Kenneth; Raji, Adeola; Peters, Georg; von Müller, Lutz; Schaumburg, Frieder; Herrmann, Mathias; Ruffing, Ulla
Fonte: Frontiers Media S.A. Publicador: Frontiers Media S.A.
Tipo: Artigo de Revista Científica
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Staphylococcus aureus is an important human pathogen causing nosocomial and community-acquired infections worldwide. In the characterization of this opportunistic pathogen, DNA microarray hybridization technique is used as an alternative to sequence based genotyping to obtain a comprehensive assessment on the virulence, resistance determinants, and population structure. The objective of this study was to characterize a defined collection of S. aureus isolates from Nigeria using the microarray technique, and to assess the extent that it correlates with sequence-based genotyping methods. The clonal diversity and genomic content of 52 methicillin-susceptible Staphylococcus aureus (MSSA) were investigated by spa typing, MLST and DNA microarray hybridization. More than half (55.8%) of these isolates were associated with clonal complexes (CCs) typically associated with methicillin-resistant S. aureus (MRSA) clones i.e., CC1, CC5, CC8, CC30, and CC45. Certain genes linked with virulence (hlgA and clfA) and adherence (ebpS, fnbA, sspA, sspB, and sspP) were detected in all isolates. A number of genes or gene clusters were associated with distinct clonal types. The enterotoxin gene cluster (egc) was linked with CC5, CC25, CC30, CC45, and CC121...

## Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology

Steentoft, Catharina; Vakhrushev, Sergey Y; Joshi, Hiren J; Kong, Yun; Vester-Christensen, Malene B; Schjoldager, Katrine T-B G; Lavrsen, Kirstine; Dabelsteen, Sally; Pedersen, Nis B; Marcos-Silva, Lara; Gupta, Ramneek; Paul Bennett, Eric; Mandel, Ulla; B
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Português
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Glycosylation is the most abundant and diverse posttranslational modification of proteins. While several types of glycosylation can be predicted by the protein sequence context, and substantial knowledge of these glycoproteomes is available, our knowledge of the GalNAc-type O-glycosylation is highly limited. This type of glycosylation is unique in being regulated by 20 polypeptide GalNAc-transferases attaching the initiating GalNAc monosaccharides to Ser and Thr (and likely some Tyr) residues. We have developed a genetic engineering approach using human cell lines to simplify O-glycosylation (SimpleCells) that enables proteome-wide discovery of O-glycan sites using ‘bottom-up' ETD-based mass spectrometric analysis. We implemented this on 12 human cell lines from different organs, and present a first map of the human O-glycoproteome with almost 3000 glycosites in over 600 O-glycoproteins as well as an improved NetOGlyc4.0 model for prediction of O-glycosylation. The finding of unique subsets of O-glycoproteins in each cell line provides evidence that the O-glycoproteome is differentially regulated and dynamic. The greatly expanded view of the O-glycoproteome should facilitate the exploration of how site-specific O-glycosylation regulates protein function.

## Identification of Human Serum Peptides in Fourier Transform Ion Cyclotron Resonance Precision Profiles

Nicolardi, Simone; Dalebout, Hans; Bladergroen, Marco R.; Mesker, Wilma E.; Tollenaar, Rob A. E. M.; Deelder, André M.; van der Burgt, Yuri E. M.
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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The continuous efforts to find new prognostic or diagnostic biomarkers have stimulated the use of mass spectrometry (MS) profiles in a clinical setting. In the early days (about one decade ago), a single low-resolution mass spectrum derived from an individual's body fluid was used for comparative studies. However, a peptide profile of a complex mixture is most informative when recorded on an ultrahigh resolution instrument such as a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. In this study we show the benefits of the ultrahigh resolving power and the high mass accuracy and precision provided by an FTICR mass spectrometer equipped with a 15-tesla magnet. The ultrahigh-resolution data not only allow assignment of fragment ions with high charge states (4+, 5+) but also enhance confidence of human serum peptide identifications from tandem MS experiments. This is exemplified with collision-induced dissociation (CID) and electron transfer dissociation (ETD) data of middle-down-sized endogenous or protein-breakdown peptides that are of interest in biomarker discovery studies.

## Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid

Kim, Hyeongmin; Ro, Jieun; Barua, Sonia; Hwang, Deuk Sun; Na, Seon-Jeong; Lee, Ho Sung; Jeong, Ji Hoon; Woo, Seulki; Kim, Hyewon; Hong, Bomi; Yun, Gyiae; Kim, Joong-Hark; Yoon, Young-Ho; Park, Myung-Gyu; Kim, Jia; Sohn, Uy Dong; Lee, Jaehwi
Fonte: The Korean Physiological Society and The Korean Society of Pharmacology Publicador: The Korean Physiological Society and The Korean Society of Pharmacology
Tipo: Artigo de Revista Científica
Português
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We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance the moisturizing capability of the skin. We prepared four different cosmeceutical bases (hydrogel, oil-in-water (O/W) essence, O/W cream, and water-in-oil (W/O) cream); their moisturizing abilities were then assessed using a Corneometer®. The hydrogel was selected as the optimum base for skin moisturization based on the area under the moisture content change-time curves (AUMCC) values used as a parameter for the water hold capacity of the skin. Liposomal serine prepared by a reverse-phase evaporation method was then incorporated in the hydrogel. The liposomal serine-incorporated hydrogel (serine level=1%) showed an approximately 1.62~1.77 times greater moisturizing effect on the skin than those of hydrogel, hydrogel with serine (1%), and hydrogel with blank liposome. However, the AUMCC values were not dependent on the level of serine in liposomal serine-loaded hydrogels. Together...

## Abelian categories in dimension 2

Dupont, Mathieu
Tipo: Artigo de Revista Científica
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The goal of this thesis is to define a 2-dimensional version of abelian categories, where symmetric 2-groups play the role that abelian groups played in 1-dimensional algebra. Abelian and 2-abelian groupoid enriched categories are defined and it is proved that homology can be developed in them, including the existence of a long exact sequence of homology corresponding to an extension of chain complexes. This generalises known results for symmetric 2-groups. The examples include, in addition to symmetric 2-groups, the 2-modules on a 2-ring, which form a 2-abelian groupoid enriched category. Moreover, internal groupoids, functors and natural transformations in an abelian category C (in particular, Baez-Crans 2-vector spaces) form a 2-abelian groupoid enriched category if and only if the axiom of choice holds in C.; Comment: x + 268 pages. This is the English version of my PhD thesis; the original French version is available at http://edoc.bib.ucl.ac.be:81/ETD-db/collection/available/BelnUcetd-06112008-231800/

## On the Physical Explanation for Quantum Computational Speedup

Cuffaro, Michael E.
Tipo: Artigo de Revista Científica
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The aim of this dissertation is to clarify the debate over the explanation of quantum speedup and to submit a tentative resolution to it. In particular, I argue that the physical explanation for quantum speedup is precisely the fact that the phenomenon of quantum entanglement enables a quantum computer to fully exploit the representational capacity of Hilbert space. This is impossible for classical systems, joint states of which must always be representable as product states. Chapter 2 begins with a discussion of the most popular of the candidate physical explanations for quantum speedup: the many worlds explanation. I argue that unlike the neo-Everettian interpretation of quantum mechanics it does not have the conceptual resources required to overcome the `preferred basis objection'. I further argue that the many worlds explanation, at best, can serve as a good description of the physical process which takes place in so-called network-based computation, but that it is incompatible with other models of computation such as cluster state quantum computing. I next consider, in Chapter 3, a common component of most other candidate explanations of quantum speedup: quantum entanglement. I investigate whether entanglement can be said to be a necessary component of any explanation for quantum speedup...

## Relaxation of interstitials in spherical colloidal crystals

Roshal, D. S.; Myasnikova, A. E.; Rochal, S. B.
Tipo: Artigo de Revista Científica
Português
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Spherical colloidal crystals (CCs) self-assemble on the interface between two liquids. These 2D structures unconventionally combine local hexagonal order and spherical geometry. Nowadays CCs are actively studied by altering their structures. However, the statistical analysis of such experiments results is limited by uniqueness of self-assembled structures and their short lifetime. Here we perform numerical experiments to investigate pathways of CC structure relaxation after the intrusion of interstitial. The process is simulated in the frames of overdamped molecular dynamics method. The relaxation occurs due to interaction with extended topological defects (ETDs) mandatory induced in spherical CCs by their intrinsic Gaussian curvature. Types of relaxation pathways are classified and their probabilities are estimated in the low-temperature region. To analyze the structural changes during the relaxation we use a parent phase approach allowing us to describe the global organization of spherical order. This organization is preserved by only the most typical relaxation pathway resulting in filling one of vacancies integrated inside the ETD areas. In contrast with this pathway the other ones shift the ETDs centers and can strongly reconstruct the internal structure of ETDs. Temperature dependence of the relaxation processes and the mechanism of dislocation unbinding are discussed. Common peculiarities in relaxation of spherical structures and particular fragments of planar hexagonal lattice are found.; Comment: 12 pages...

## QCD Structure of Nuclear Interactions

Tipo: Artigo de Revista Científica
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This dissertation investigated selected processes involving baryons and nuclei in hard scattering reactions. Through these processes, this work explored the constituent structure of baryons and the mechanisms through which the interactions between these constituents ultimately control the selected reactions. First, hard nucleon-nucleon elastic scattering was studied considering the quark exchange (QE) between the nucleons to be the dominant mechanism of interaction in the constituent picture. It was found that an angular asymmetry exhibited by proton-neutron (pn) elastic scattering data is explained within this framework if a quark-diquark picture dominates the nucleon's structure instead of a more traditional SU(6) model. The latter yields an asymmetry around 90 deg center of mass scattering with a sign opposite to what is experimentally observed. The second process is the hard breakup by a photon of a nucleon-nucleon system in light nuclei. Proton-proton (pp) and pn breakup in 3He, and double Delta-isobars production in deuteron breakup were analyzed in the hard rescattering model (HRM), which in conjunction with the QE mechanism provides a QCD description of the reaction. Cross sections for both channels in 3He photodisintegration were computed without the need of a fitting parameter. The results presented here for pp breakup show excellent agreement with recent experimental data. In double Delta-isobars production in deuteron breakup...

## Structures in 3D double-diffusive convection and possible approach to the Saturn's polar hexagon modeling

Kozitskiy, S. B.
Tipo: Artigo de Revista Científica
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Three-dimensional double-diffusive convection in a horizontally infinite layer of an uncompressible fluid interacting with horizontal vorticity field is considered in the neighborhood of Hopf bifurcation points. A family of amplitude equations for variations of convective cells amplitude is derived by multiple-scaled method. Shape of the cells is given as a superposition of a finite number of convective rolls with different wave vectors. For numerical simulation of the obtained systems of amplitude equations a few numerical schemes based on modern ETD (exponential time differencing) pseudo-spectral methods were developed. The software packages were written for simulation of roll-type convection and convection with square and hexagonal type cells. Numerical simulation has showed that the convection takes the form of elongated "clouds", "spots" or "filaments". It was noted that in the system quite rapidly a state of diffusive chaos is developed, where the initial symmetric state is destroyed and the convection becomes irregular both in space and time. The obtained results may be the basis for the construction of more advanced models of multi-component convection, for instance, model of Saturn's polar hexagon.; Comment: 11 pages, 6 figures

## QCD Sum Rule Studies of Heavy Quarkonium-like States

Kleiv, Robin
Tipo: Artigo de Revista Científica
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The research presented here uses QCD sum rules (QSR) to study exotic hadrons. There are several themes in this work. First is the use of QSR to predict the masses of exotic hadrons that may exist among the heavy quarkonium-like states. The second theme is the application of sophisticated loop integration methods in order to obtain more complete theoretical results. These in turn can be extended to higher orders in the perturbative expansion in order to predict the properties of exotic hadrons more accurately. The third theme involves developing a renormalization methodology for these higher order calculations. This research has implications for the $Y(3940)$, $X(3872)$, $Z_c^\pm\left(3895\right)$, $Y_b\left(10890\right)$, $Z_b^{\pm}(10610)$ and $Z_b^{\pm}(10650)$ particles, thereby contributing to the ongoing effort to understand these and other heavy quarkonium-like states.; Comment: PhD thesis (University of Saskatchewan, September 2013), based on arXiv:1206.6776, arXiv:1204.0049, arXiv:1304.7816, arXiv:1010.2971 and arXiv:0804.2195. This is an abridged version with links to preprints and published articles. Full version at http://hdl.handle.net/10388/ETD-2012-09-1319 . 124 pages, 18 figures

## Exoplanet Transit Database. Reduction and processing of the photometric data of exoplanet transits

Poddaný, Stanislav; Brát, Luboš; Pejcha, Ondřej
Tipo: Artigo de Revista Científica
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We demonstrate the newly developed resource for exoplanet researchers - The Exoplanet Transit Database. This database is designed to be a web application and it is open for any exoplanet observer. It came on-line in September 2008. The ETD consists of three individual sections. One serves for predictions of the transits, the second one for processing and uploading new data from the observers. We use a simple analytical model of the transit to calculate the central time of transit, its duration and the depth of the transit. These values are then plotted into the observed - computed diagrams (O-C), that represent the last part of the application.; Comment: Accepted to NewAstronomy

## On Convergence of Emphatic Temporal-Difference Learning

Yu, Huizhen
Tipo: Artigo de Revista Científica
Português
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We consider emphatic temporal-difference learning algorithms for policy evaluation in discounted Markov decision processes with finite spaces. Such algorithms were recently proposed by Sutton, Mahmood, and White (2015) as an improved solution to the problem of divergence of off-policy temporal-difference learning with linear function approximation. We present in this paper the first convergence proofs for two emphatic algorithms, ETD($\lambda$) and ELSTD($\lambda$). We prove, under general off-policy conditions, the convergence in $L^1$ for ELSTD($\lambda$) iterates, and the almost sure convergence of the approximate value functions calculated by both algorithms using a single infinitely long trajectory. Our analysis involves new techniques with applications beyond emphatic algorithms leading, for example, to the first proof that standard TD($\lambda$) also converges under off-policy training for $\lambda$ sufficiently large.; Comment: 45 pages; an oversight in a proof in Appendix C of the first version has been corrected. A shorter article based on the first version appeared at the 28th Annual Conference on Learning Theory (COLT), 2015

## Supernova Remnants as a Probe of Dust Grains in the Interstellar Medium

Williams, Brian J.
Tipo: Artigo de Revista Científica
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Interstellar dust grains play a crucial role in the evolution of the galactic interstellar medium (ISM). Despite its importance, however, dust remains poorly understood in terms of its origin, composition, and abundance throughout the universe. Supernova remnants (SNRs) provide a laboratory for studying the evolution of dust grains, as they are one of the only environments in the universe where it is possible to observe grains being both created and destroyed. SNRs exhibit collisionally heated dust, allowing dust to serve as a diagnostic both for grain physics and for the plasma conditions in the SNR. I present theoretical models of collisionally heated dust which calculate grain emission as well as destruction rates. In these models, I incorporate physics such as nonthermal sputtering caused by grain motions through the gas, a more realistic approach to sputtering for small grains, and arbitrary grain compositions porous and composite grains. I apply these models to infrared and X-ray observations of Kepler's supernova and the Cygnus Loop in the galaxy, and SNRs 0509-67.5, 0519-69.0, and 0540-69.3 in the LMC. X-ray observations characterize the hot plasma while IR observations constrain grain properties and destruction rates. Such a multi-wavelength approach is crucial for a complete understanding of gas and dust interaction and evolution. Modeling of both X-ray and IR spectra allows disentangling of parameters such as pre and postshock gas density...

## Planetary transit observations at the University Observatory Jena: XO-1b and TrES-1

Raetz, St.; Mugrauer, M.; Schmidt, T. O. B.; Roell, T.; Eisenbeiss, T.; Hohle, M. M.; Tetzlaff, N.; Vanko, M.; Seifahrt, A.; Broeg, Ch.; Koppenhoefer, J.; Neuhäuser, R.
Tipo: Artigo de Revista Científica
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We report on observations of transit events of the transiting planets XO-1b and TrES-1 with a 25 cm telescope of the University Observatory Jena. With the transit timings for XO-1b from all 50 available XO, SuperWASP, Transit Light Curve (TLC)-Project- and Exoplanet Transit Database (ETD)-data, including our own I-band photometry obtained in March 2007, we find that the orbital period is P= (3.941501 +/- 0.000001) d, a slight change by ~3 s compared to the previously published period. We present new ephemeris for this transiting planet. Furthermore, we present new R-band photometry of two transits of TrES-1. With the help of all available transit times from literature this allows us to refine the estimate of the orbital period: P=(3.0300722 +/- 0.0000002) d. Our observations will be useful for future investigations of timing variations caused by additional perturbing planets and/or stellar spots and/or moons.; Comment: 7 pages, 7 figures, 5 tables, accepted for publication in AN

## Combinatorial Techniques in the Galois Theory of $p$-Extensions

Tipo: Artigo de Revista Científica
A major open problem in current Galois theory is to characterize those profinite groups which appear as absolute Galois groups of various fields. Obtaining detailed knowledge of the structure of quotients and subgroup filtrations of Galois groups of $p$-extensions is an important step toward a solution. We illustrate several techniques for counting Galois $p$-extensions of various fields, including pythagorean fields and local fields. An expression for the number of extensions of a formally real pythagorean field having Galois group the dihedral group of order 8 is developed. We derive a formula for computing the $\mathbb{F}_p$-dimension of an $n$-th graded piece of the Zassenhaus filtration for various finitely generated pro-$p$ groups, including free pro-$p$ groups, Demushkin groups and their free pro-$p$ products. Several examples are provided to illustrate the importance of these dimensions in characterizing pro-$p$ Galois groups. We also show that knowledge of small quotients of pro-$p$ Galois groups can provide information regarding the form of relations among the group generators.; Comment: PhD thesis, The University of Western Ontario (see http://ir.lib.uwo.ca/etd/2905), 127 pages