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THE QUANTITATIVE CHANGES IN THE PROTEINS IN THE BLOOD PLASMA OF HORSES IN THE COURSE OF IMMUNIZATION

Gibson, Robert Banks; Banzhaf, Edwin J.
Fonte: The Rockefeller University Press Publicador: The Rockefeller University Press
Tipo: Artigo de Revista Científica
Publicado em 01/05/1910 Português
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144.84746%
Gravimetric determinations were recorded for the total and several individual proteins (in the sodium oxalate plasma) fractioned with ammonium sulphate and sodium chloride. At precipitation, the plasma salt mixture had been diluted to a final volume of ten times the amount of plasma employed. Coagulations were on aliquot portions of filtrates, and the individual protein constituents (except serumalbumin) were calculated by difference. The eleven horses had been subjected to simultaneous immunization against diphtheria and tetanus toxins, each horse being subsequently continued on the toxin to which it responded best. Test bleedings of about 500 cubic centimeters only were made until maximum antitoxic potency (with almost coincident greatest variation See PDF for Structure in the contents of the several proteins) had been attained; routine bleedings of four to ten liters for antitoxin production were then instituted. The two refractory, one medium and the eight horses yielding a highly potent antitoxic plasma, all showed an increase of from 40 to 114 per cent. in the total serumglobulin. For the refractory animals, this increase was 59.3 and 87.9 per cents. In one refractory and in one high horse, the serumglobulin maximum preceded the highest concentration in antitoxin. In seven of the horses...

THE INFLUENCE OF THE FACTORS OF SEX, AGE, AND METHOD OF INOCULATION UPON THE COURSE OF EXPERIMENTAL SYPHILIS IN THE RABBIT

Chesney, Alan M.
Fonte: The Rockefeller University Press Publicador: The Rockefeller University Press
Tipo: Artigo de Revista Científica
Publicado em 31/10/1923 Português
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144.84746%
For convenience the results are summarized in tabular form. Table I shows a comparison of the primary reaction in the groups of female and male rabbits inoculated intradermally. In Table II the incidence of metastatic lesions is shown in the various groups of animals. In Table III are shown the character and date of appearance of the generalized lesions (exclusive of orchitis) in the various groups of animals. The results presented in Tables I, II, and III, together with a study of the individual protocols, permit the following general statements to be made relative to the effect of the factors studied upon the course of experimental syphilis in the rabbit. Sex.—In the group of females inoculated intradermally the lesions at the site of inoculation were in general less marked than in the group of males similarly inoculated. Moreover, they attained their maximum size earlier and began to recede earlier than was the case in the males. In none of the females was there clinical evidence of the production of generalized lesions, while in the corresponding group of males metastatic lesions of skin or bones detectible by clinical examination occurred in one instance, or 14.3 per cent. In both groups there was wide variation in the character of the initial reaction in individual rabbits and in the time required for it to reach its maximum size. See PDF for Structure Age.—In the five young males inoculated intratesticularly the disease was not greatly different from that observed in the older males similarly inoculated. The initial reactions were slightly slower in making their appearance...