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Web-Based Science Gateways for Structural Bioinformatics; Webbasierte Science Gateways für Strukturbioinformatik

Gesing, Sandra
Fonte: Universität Tübingen Publicador: Universität Tübingen
Tipo: Dissertation; info:eu-repo/semantics/doctoralThesis
Relevância na Pesquisa
Structural bioinformatics applies computational methods to analyse and model three-dimensional molecular structures. These methods address data-intensive and compute-intensive problems, which demand high-performance computing (HPC) to allow data analysis in an acceptable time. Thus, structural bioinformatic applications are ideal candidates for grid and cloud computing infrastructures, so-called DCIs (Distributed Computing Infrastructures). DCIs provide access to HPC facilities and services across organisational boundaries. However, the usability of DCIs is limited and the use of the complex methods in structural bioinformatics requires a lot of experience. In addition, users mainly process and analyse data not only via single jobs but via workflows. An approach to offer easy and intuitive access to applications on DCIs are science gateways. In general, a science gateway provides a single point of entry to a set of tools and data of a specific application domain while hiding the complex underlying infrastructure. Web-based science gateways are additionally characterised by only requiring a computer connected to the Internet and an installed web browser on the users' side. Developers of such gateways support the users with pre-configured user interfaces targeted for a specific application domain. The overall goal for creating science gateways is to increase the usability of applications. This work is focused on workflow-enabled grid portals that are specific web-based science gateways supporting the management of workflows on DCIs. Four major aspects in the context of workflow-enabled grid portals are addressed in this work: security in portals with underlying DCIs...