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NF-κB in Cellular Senescence and Cancer Treatment

Jing, Hua; Lee, Soyoung
Fonte: Korean Society for Molecular and Cellular Biology Publicador: Korean Society for Molecular and Cellular Biology
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
57.489883%
The NF-κB pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-κB in cancer cells, recent findings postulate that NF-κB participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-κB. In this review, we discuss implications of the NF-κB signaling pathway in cancer. Particularly, we emphasize the connection of NF-κB with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-κB produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.