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Transtorno afetivo bipolar e a ambivalência em relação à terapia medicamentosa: analisando as condições causais; Affective bipolar disorder and ambivalence in relation to the drug treatment: analyzing the causal conditions; Transtorno afectivo bipolar y la ambivalencia en relación a la terapia medicamentosa: analizando las condiciones causales

MIASSO, Adriana Inocenti; CASSIANI, Silvia Helena De Bortoli; PEDRÃO, Luiz Jorge
Fonte: Universidade de São Paulo, Escola de Enfermagem Publicador: Universidade de São Paulo, Escola de Enfermagem
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
57.61783%
Este estudo buscou compreender as condições causais da ambivalência da pessoa com transtorno afetivo bipolar (TAB) em relação ao seguimento da terapêutica medicamentosa. Foi utilizada a abordagem qualitativa, tendo como referencial metodológico a Teoria Fundamentada nos Dados, à luz do Interacionismo Simbólico. Participaram do estudo 14 pessoas com TAB que estavam em acompanhamento em um Ambulatório de Transtornos do Humor de um hospital universitário e 14 familiares indicados pelas mesmas. A entrevista e observação foram as principais formas de obtenção de dados. Os resultados revelaram três categorias que descrevem as referidas condições causais: vivendo as crises do transtorno; tendo necessidade do medicamento e convivendo com os efeitos colaterais dos medicamentos. Este estudo aponta para necessidade de mudança de atitude dos profissionais de saúde de culpabilizar o paciente pela interrupção do tratamento para aquela de escuta, de valorização do seu universo simbólico e afetivo bem como de parceria no tratamento.; This study was performed with an aim to understand the conditions causing the ambivalence of the person with bipolar affective disorder (BAD) regarding following the drug treatment. A qualitative approach was used...

Esquizofrenia: adesão ao tratamento e crenças sobre o transtorno e terapêutica medicamentosa; Schizophrenia: adherence to treatment and beliefs about the disorder and the drug treatment; Esquizofrenia: adhesión al tratamiento y creencias sobre el transtorno y terapéutica medicamentosa

NICOLINO, Paula Silva; VEDANA, Kelly Graziani Giacchero; MIASSO, Adriana Inocenti; CARDOSO, Lucilene; GALERA, Sueli Aparecida Frari
Fonte: Universidade de São Paulo, Escola de Enfermagem Publicador: Universidade de São Paulo, Escola de Enfermagem
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
57.70172%
Este estudo verificou a adesão de pessoas com esquizofrenia à medicação, identificou e comparou as crenças sobre transtorno e medicamento entre pacientes aderentes e não aderentes. Participaram do estudo 14 pacientes de um ambulatório de psiquiatria. Foi realizada entrevista semi-estruturada e aplicação do Teste de Morisky-Green. Os dados foram analisados com abordagem quali-quantitativa. Os resultados revelaram que 64,3% dos pacientes não aderem ao medicamento. A maioria dos entrevistados considerou a medicação capaz de reduzir a seriedade e severidade do transtorno. Entretanto, entre pacientes não aderentes, as barreiras no seguimento da terapêutica foram mais expressivas. Efeitos colaterais foram razão para descontinuidade do tratamento em 80% dos pacientes não aderentes intencionalmente. Observou-se conhecimento insuficiente sobre a esquizofrenia e tratamento medicamentoso. A fé foi mencionada pelos pacientes como estratégia para enfrentamento do processo vivenciado. Este estudo aponta para a necessidade de estratégias direcionadas à promoção da adesão ao medicamento entre pessoas com esquizofrenia.; This study verified the adherence of people with schizophrenia to the medication, identified and compared their beliefs about the disorder and the drug among patients who adhered and those who did not. Participants were 14 patients of a psychiatric outpatient clinic. Semi-structured interviews and the Morisky-Green test were performed. The data was analyzed using a quali-quantitative approach. Results showed that 64.3% of patients do not adhere to treatment. Most participants considered the drug capable of reducing the seriousness and severity of the disorder. However...

Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia

TOSCANO, Claudia Alvares; KAMEYAMA, Marcia; GARCIA-MIJARES, Miriam; SILVA, Maria Teresa Araujo; SANTAREM, Erica Maria Machado
Fonte: PERGAMON-ELSEVIER SCIENCE LTD Publicador: PERGAMON-ELSEVIER SCIENCE LTD
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
48.54454%
Studies have suggested a relationship between drug abuse and compulsive behaviors. The present experiments investigated the relationship between schedule-induced polydipsia (SIP) and self-administration (SA) of ethanol and sucrose. SIP served as a model of compulsive behavior. and oral self-administration on a progressive-ratio (PR) schedule of reinforcement assessed the reinforcing value of either a 10% ethanol solution or an isocaloric sucrose solution. Rats first were exposed to PR sessions in which break points were the dependent variable and then switched to SIP sessions. with number of licks as the dependent variable. Results showed a positive relationship between PR and SIP for sucrose but not for ethanol: higher and lower PRs for sucrose were associated with higher and lower SIP levels. The order of the sessions then was reversed, such that SIP sessions were run before PR sessions. An opposite relationship was observed in which high and low SIP animals exhibited low and high PR break points, respectively. The relationship between SIP and SA was dependent on the reinforcing value of the substance and on prior SIP exposure. These results may reflect a common dopaminergic substrate and suggest that prior experience in coping with stress may reduce vulnerability to substance abuse behavior. (c) 2008 Published by Elsevier Inc.

Análise de risco do processo de administração de medicamentos por via intravenosa em pacientes de um hospital universitário de Goiás; Risk analysis of intravenous drug administration to patients in a University Hospital in Goiás, Brazil.

Silva, Ana Elisa Bauer de Camargo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 18/12/2008 Português
Relevância na Pesquisa
48.34902%
O processo de administração de medicamentos é considerado um processo complexo, crítico e de alto risco para os pacientes e tem apresentado altas taxas de ocorrência de eventos adversos que poderiam ser evitados. Este estudo teve o objetivo de analisar os riscos potenciais do processo de administração de medicamentos antiinfecciosos por via intravenosa de uma unidade de internação, visando a prevenir e a reduzir eventos adversos com medicamentos. A investigação, de natureza exploratória, foi realizada na unidade de Clínica Médica de um Hospital do Estado de Goiás, utilizando o Método de Análise do Modo e Efeito da Falha. Participaram do estudo, além da pesquisadora, seis profissionais envolvidos na terapêutica medicamentosa: médico, enfermeiro, técnico de enfermagem, farmacêutico e os gerentes de Enfermagem e de risco. Foram realizadas 24 reuniões, no período de 19 de fevereiro a 3 de julho de 2008, totalizando 56 horas. Todas os dados foram transcritos e armazenados em um banco eletrônico no programa Microsoft Excel® e analisados no software XFMEA 4. Os resultados indicaram que o processo de administração de medicamentos possui quatro microprocessos, dez atividades e 22 funções. No processo foram identificados 52 modos potenciais da falha (MPF)...

A comparative evaluation of open loop and closed loop drug administration strategies in the treatment of AIDS.

Caetano, M. A.; Yoneyama, T.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 589-597
Português
Relevância na Pesquisa
68.03711%
In recent years, many researchers in the field of biomedical sciences have made successful use of mathematical models to study, in a quantitative way, a multitude of phenomena such as those found in disease dynamics, control of physiological systems, optimization of drug therapy, economics of the preventive medicine and many other applications. The availability of good dynamic models have been providing means for simulation and design of novel control strategies in the context of biological events. This work concerns a particular model related to HIV infection dynamics which is used to allow a comparative evaluation of schemes for treatment of AIDS patients. The mathematical model adopted in this work was proposed by Nowak & Bangham, 1996 and describes the dynamics of viral concentration in terms of interaction with CD4 cells and the cytotoxic T lymphocytes, which are responsible for the defense of the organism. Two conceptually distinct techniques for drug therapy are analyzed: Open Loop Treatment, where a priori fixed dosage is prescribed and Closed Loop Treatment, where the doses are adjusted according to results obtained by laboratory analysis. Simulation results show that the Closed Loop Scheme can achieve improved quality of the treatment in terms of reduction in the viral load and quantity of administered drugs...

Acute and sustained effects of early administration of inhaled nitric oxide to children with acute respiratory distress syndrome.

Fioretto, José R; de Moraes, Marcos A; Bonatto, Rossano C; Ricchetti, Sandra M Q; Carpi, Mário F
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 469-474
Português
Relevância na Pesquisa
58.206953%
OBJECTIVE: To determine the acute and sustained effects of early inhaled nitric oxide on some oxygenation indexes and ventilator settings and to compare inhaled nitric oxide administration and conventional therapy on mortality rate, length of stay in intensive care, and duration of mechanical ventilation in children with acute respiratory distress syndrome. DESIGN: Observational study. SETTING: Pediatric intensive care unit at a university-affiliated hospital. PATIENTS: Children with acute respiratory distress syndrome, aged between 1 month and 12 yrs. INTERVENTIONS: Two groups were studied: an inhaled nitric oxide group (iNOG, n = 18) composed of patients prospectively enrolled from November 2000 to November 2002, and a conventional therapy group (CTG, n = 21) consisting of historical control patients admitted from August 1998 to August 2000. MEASUREMENTS AND MAIN RESULTS: Therapy with inhaled nitric oxide was introduced as early as 1.5 hrs after acute respiratory distress syndrome diagnosis with acute improvements in Pao(2)/Fio(2) ratio (83.7%) and oxygenation index (46.7%). Study groups were of similar ages, gender, primary diagnoses, pediatric risk of mortality score, and mean airway pressure. Pao(2)/Fio(2) ratio was lower (CTG...

Neurohormonal, hemodynamic, and electrocardiographic evaluations of healthy dogs receiving long-term administration of doxorubicin

Alves de Souza, Rute Chamié; Camacho, Aparecido Antonio
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 1319-1325
Português
Relevância na Pesquisa
57.93115%
Objective - To evaluate diagnostic testing that could be used to establish an early diagnosis of cardiotoxicosis induced by long-term administration of doxorubicin. Animals - 13 adult mixed-breed dogs. Procedures - 7 dogs were administered doxorubicin chloride (30 mg/m2, IV, q 21 d for 168 days [cumulative dose, 240 mg/m2]), and 6 dogs received saline (0.9% NaCl) solution (5 mL, IV, q 21 d for 168 days; control group). Echocardiography, ECG, arterial blood pressure, plasma renin activity (PRA), and plasma concentrations of norepinephrine and brain natriuretic peptide (BNP) were assessed before each subsequent administration of doxorubicin and saline solution. Results - Dogs that received doxorubicin had a significant decrease in R-wave amplitude, compared with values for the control group, from 30 to 210 mg/m2. Doxorubicin-treated dogs had decreases in fractional shortening and left ventricular ejection fraction evident as early as 30 mg/m2, but significant differences between groups were not detected until 90 mg/m2 was reached. There was also a significant increase in PRA (≥ 120 mg/m2) and left ventricular end-systolic and end-diastolic dimensions (≥ 60 and ≥ 180 mg/m2, respectively). Systemic arterial pressure, remaining echocardiographic variables...

Progesterone-based strategies to induce ovulation in prepubertal Nellore heifers

Rodrigues, A. D P; Peres, R. F G; Lemes, A. P.; Martins, T.; Pereira, M. H C; Day, M. L.; Vasconcelos, J. L M
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 135-141
Português
Relevância na Pesquisa
47.9715%
Four experiments were conducted to evaluate hormonal strategies to induce ovulation in Nellore heifers. In experiment 1, heifers (N = 1039) received a controlled internal drug release (CIDR) of fourth use (CIDR-4) on Day -12 or no CIDR (CIDR-0). The CIDR was removed on Day 0 in the CIDR-4 treatment, and estrus detection and AI were performed from Days 1 to 7. On Day 8, heifers not detected in estrus were evaluated for CL presence and received the same treatment again, followed by estrus detection and AI from Days 21 to 27. All heifers in experiments 2 (N = 896), 3 (N = 839), and 4 (N = 948) received the CIDR-4 treatment on Day -12. In experiment 2, heifers were randomly assigned to a control group (no additional treatment) or to receive equine chorionic gonadotropin (eCG; 200 IU eCG im) on Day 0. In experiment 3, heifers received the same treatments as in experiment 2, or a treatment that included eCG and estradiol cypionate (ECP) (eCG+ECP; 200 IU im eCG plus 0.5 mg ECP im) on Day 0. In experiment 4, heifers received the treatments described in experiment 3 or only ECP (0.5 mg) on Day 0. In experiments 2 and 3, estrus detection and AI was performed from Days 1 to 7 and on Day 8, heifers not detected in estrus were evaluated for CL presence. In experiment 4...

Chronic administration of risperidone in a rat model of schizophrenia: A behavioural, morphological and molecular study

Castellano, O.; Arji, M.; Sancho, C.; Carro, J.; Riolobos, A. S.; Molina, V.; Gómez-Nieto, R.; de Anchieta de Castro e Horta, José; Herrero-Turrión, M. J.; López, D. E.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 178-190
Português
Relevância na Pesquisa
57.9695%
In the present work we analyzed the effect of the chronic administration of risperidone (2mg/kg over 65 days) on behavioural, morphological and molecular aspects in an experimental model of schizophrenia obtained by bilateral injection of ibotenic acid into the ventral hippocampus of new-born rats. Our results show that during their adult lives the animals with hippocampal lesions exhibit different alterations, mainly at behavioural level and in the gene expression of dopamine D2 and 5-HT2A receptors. However, at morphological level the study performed on the prefrontal cortex did not reveal any alterations in either the thickness or the number of cells immunoreactive for c-Fos, GFAP, CBP or PV. Overall, risperidone administration elicited a trend towards the recovery of the values previously altered by the hippocampal lesion, approaching the values seen in the animals without lesions. It may be concluded that the administration of risperidone in the schizophrenia model employed helps to improve the altered functions, with no significant negative effects. © 2013.

Mathematical and computational models of drug transport in tumours

Groh, C. M.; Hubbard, M. E.; Jones, P. F.; Loadman, P. M.; Periasamy, N.; Sleeman, B. D.; Smye, S. W.; Twelves, C. J.; Phillips, R. M.
Fonte: The Royal Society Publicador: The Royal Society
Tipo: Artigo de Revista Científica
Publicado em 06/05/2014 Português
Relevância na Pesquisa
48.413433%
The ability to predict how far a drug will penetrate into the tumour microenvironment within its pharmacokinetic (PK) lifespan would provide valuable information about therapeutic response. As the PK profile is directly related to the route and schedule of drug administration, an in silico tool that can predict the drug administration schedule that results in optimal drug delivery to tumours would streamline clinical trial design. This paper investigates the application of mathematical and computational modelling techniques to help improve our understanding of the fundamental mechanisms underlying drug delivery, and compares the performance of a simple model with more complex approaches. Three models of drug transport are developed, all based on the same drug binding model and parametrized by bespoke in vitro experiments. Their predictions, compared for a ‘tumour cord’ geometry, are qualitatively and quantitatively similar. We assess the effect of varying the PK profile of the supplied drug, and the binding affinity of the drug to tumour cells, on the concentration of drug reaching cells and the accumulated exposure of cells to drug at arbitrary distances from a supplying blood vessel. This is a contribution towards developing a useful drug transport modelling tool for informing strategies for the treatment of tumour cells which are ‘pharmacokinetically resistant’ to chemotherapeutic strategies.

Two Mifepristone Doses and Two Intervals of Misoprostol Administration for Termination of Early Pregnancy : A Randomised Factorial Controlled Equivalence Trial

von Hertzen, H.; Piaggio, G.; Wojdyla, D.; Marions, L.; My Huong, N. T.; Tang, O. S.; Fang, A. H.; Wu, S. C.; Kalmar, L.; Mittal, S.; Erdenetungalag, R.; Horga, M.; Pretnar-Darovec, A.; Kapamadzija, A.; Dickson, K.; Anh, N. D.; Tai, N. V.; Tuyet, H. T.; P
Fonte: Banco Mundial Publicador: Banco Mundial
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
57.74644%
OBJECTIVE: To compare the efficacy of 100 mg and 200 mg of mifepristone and 24- and 48-hour intervals to administration of 800 microg vaginal misoprostol for termination of early pregnancy. DESIGN: Placebo-controlled, randomized, equivalence trial, stratified by centre. SETTING: 13 departments of obstetrics and gynecology in nine countries. POPULATION: 2,181 women with 63 days or less gestation requesting medical abortion. METHODS: Two-sided 95% CI for the risk differences of failure to complete abortion were calculated and compared with 5% equivalence margin between two doses of mifepristone and two intervals to misoprostol administration. Proportions of women with adverse effects were compared between the regimens using standard testes for proportions. OUTCOME MEASURES: Rates of complete abortion without surgical intervention and adverse effects associated with the regimens. RESULTS: Efficacy outcome was analysed for 2,126 women (97.5%) excluding 55 lost to follow up. Both mifepristone doses were found to be similar in efficacy. The rate of complete abortion was 92.0% for women assigned 100 mg of mifepristone and 93.2% for women assigned 200 mg of mifepristone (difference 1.2%, 95% CI: -1.0 to 3.5). Equivalence was also evident for the two intervals of administration: the rate of complete abortion was 93.5% for 24-hour interval and 91.7% for the 48-hour interval (difference -1.8%...

The effect of rate of administration on brain concentrations of propofol in sheep

Ludbrook, G.; Upton, R.; Grant, C.; Martinez, A.
Fonte: International Anesthesia Research Society Publicador: International Anesthesia Research Society
Tipo: Artigo de Revista Científica
Publicado em //1998 Português
Relevância na Pesquisa
58.183794%
UNLABELLED: A marked reduction in the dose of propofol required to achieve the onset of anesthesia with slower administration rates has previously been reported, but the mechanism of this phenomenon is unclear. We used a chronically instrumented sheep preparation to examine the effects of different administration rates of propofol on its distribution in the brain using mass balance principles to calculate brain concentrations. The administration of 100 mg of propofol i.v. at rates of 200, 50, and 20 mg/min had minimal effect on both the peak brain concentrations of propofol and the total amount of drug entering the brain. The more rapid administration rates increased the rate of uptake into the brain but resulted in large increases in peak arterial blood propofol concentrations. These faster administration rates have previously been associated with high arterial propofol concentrations and an increased risk of hypotension. Simulation of titration to an end point revealed that the dose sparing previously reported at induction with slow administration rates relates only to improved titration to effect, and does not result in more anesthesia for a given dose. Therefore, we conclude that the administration of propofol over 2 min provides a reasonable rate of induction and improved titration to effect...

Pancreatic β-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes; Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes

Harrison, L.; Honeyman, B.; Steele, C.; Stone, N.; Sarugeri, E.; Bonifacio, E.; Couper, J.; Coleman, P.
Fonte: Amer Diabetes Assoc Publicador: Amer Diabetes Assoc
Tipo: Artigo de Revista Científica
Publicado em //2004 Português
Relevância na Pesquisa
57.93115%
OBJECTIVE: Mucosal administration of insulin retards development of autoimmune diabetes in the nonobese diabetic mouse model. We conducted a double-blind crossover study in humans at risk for type 1 diabetes to determine if intranasal insulin was safe, in particular did not accelerate beta-cell destruction, and could induce immune effects consistent with mucosal tolerance. RESEARCH DESIGN AND METHODS: A total of 38 individuals, median age 10.8 years, with antibodies to one or more pancreatic islet antigens (insulin, GAD65, or tyrosine phosphatase-like insulinoma antigen 2) were randomized to treatment with intranasal insulin (1.6 mg) or a carrier solution, daily for 10 days and then 2 days a week for 6 months, before crossover. The primary outcome was beta-cell function measured as first-phase insulin response (FPIR) to intravenous glucose at 0, 6, and 12 months and then yearly; the secondary outcome was immunity to islet antigens, measured monthly for 12 months. RESULTS: No local or systemic adverse effects were observed. Diabetes developed in 12 participants with negligible beta-cell function at entry after a median of 1.1 year. Of the remaining 26, the majority had antibodies to two or three islet antigens and FPIR greater than the first percentile at entry...

Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children

Roberton, D.; Marshall, H.; Nolan, T.; Sokal, E.; Diez-Domingo, J.; Flodmark, C.E.; Rombo, L.; Lewald, G.; de la Flor, J.; Casanaovas, J.; Verdaguer, J.; Mares, J.; Van Esso, D.; Dieussaert, I.; Stoffel, M.
Fonte: Elsevier Sci Ltd Publicador: Elsevier Sci Ltd
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
Relevância na Pesquisa
47.87252%
This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7).

Therapeutic drug monitoring of once daily tobramycin in cystic fibrosis - caution with trough concentrations

Coulthard, K.; Peckham, D.; Conway, S.; Smith, C.; Bell, J.; Turnidge, J.
Fonte: Elsevier BV Publicador: Elsevier BV
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
Relevância na Pesquisa
57.61783%
BACKGROUND: : Once daily intravenous aminoglycoside dosing (ODD) is widely used to treat acute Pseudomonas aeruginosa exacerbations in patients with cystic fibrosis. Controversy exists as to what is the most appropriate method of therapeutic drug monitoring (TDM) of such therapy with recommendations including trough plasma concentrations of <1 mg/L or <2 mg/L, area under curve (AUC) and various nomograms. This study aimed to compare the exposures to ODD of tobramycin in adults and children with cystic fibrosis using the AUC and trough TDM approaches. METHODS: : Using a mono-exponential software program to calculate AUC from 2 plasma concentrations, AUCs were determined in 22 adults with pre-dose tobramycin concentrations <1 mg/L. The exposure of 5 children with reduced tobramycin clearances was simulated at the usual recommended dose of 10 mg/kg/daily but retaining a trough <1 mg/L. RESULTS: : A tobramycin dose of 10 mg/kg of tobramycin in these patients with normal serum creatinine and a trough concentration <1 mg/L resulted in exposures in excess of those associated with conventional 8-hourly dosing. CONCLUSIONS: : The TDM approach of a trough <1 mg/L, as used with conventional 8-hourly tobramycin dosing, is not relevant to ODD.; http://www.elsevier.com/wps/find/journaldescription.cws_home/622283/description#description; Kingsley P. Coulthard...

Pre- and post-nicotine circadian activity episodes are differentially affected by pharmacological treatments for drug addiction

Gillman, Andrea Grace
Fonte: [Bloomington, Ind.] : Indiana University Publicador: [Bloomington, Ind.] : Indiana University
Tipo: Doctoral Dissertation
Português
Relevância na Pesquisa
48.35333%
Thesis (Ph.D.) - Indiana University, Neuroscience, 2010; Nicotine and other drugs of abuse can act as zeitgebers and entrain persisting circadian activity episodes when administered on a 24-hour schedule. There are two types of drug-induced circadian activity episodes: a pre-drug anticipatory episode characterized by a rise in activity beginning 1-2 hours prior to the drug administration time that is not linked to any predictive environmental cue, and a post-drug evoked episode that lasts for approximately the duration of the drug's physiological half-life. The present research examined how pharmacological treatments prescribed for nicotine and other substance addictions affected pre- and post-nicotine activity episodes in adult female Sprague-Dawley rats housed in wheel boxes under constant light and rate-limited feeding. For 16 consecutive days, the rats were administered a subcutaneous "zeitgeber" injection of either nicotine or saline on a 24-hour schedule to establish pre- and post-administration activity episodes. The rats were then were administered one of nine treatment conditions in place of the zeitgeber injection for two consecutive days. The treatment conditions were No Treatment, Saline Treatment, Varenicline, Mecamylamine...

Avaliação do nível de entendimento das prescrições medicamentosas pediátricas em unidades básicas de saúde, Campo Grande, Mato Grosso do Sul

Ferreira, Valeska de Oliveira Gonçalves
Fonte: Universidade Federal de Mato Grosso do Sul Publicador: Universidade Federal de Mato Grosso do Sul
Tipo: Dissertação de Mestrado
Português
Relevância na Pesquisa
47.9165%
Ainda são poucas as referências que abordam o entendimento da prescrição pediátrica. A responsabilidade da correta administração do medicamento está relacionada à compreensão da prescrição pelo cuidador da criança. A vulnerabilidade da criança e maior chance de reações adversas fizeram do entendimento das prescrições pediátricas objeto deste estudo. Foi objetivo deste trabalho avaliar o nível de entendimento de prescrições medicamentosas pediátricas dispensadas em Unidades Básicas de Saúde (UBS), identificando os fatores relacionados a esse entendimento. No período de maio de 2007 a junho de 2008 foram entrevistados 336 acompanhantes de crianças, atendidas nas 24 UBS do município de Campo Grande, que contavam com serviço de pediatria, que receberam prescrição medicamentosa e retiraram o medicamento na farmácia da UBS. Foi aplicado um questionário para avaliar a situação cultural e fatores relacionados à compreensão da prescrição como a legibilidade, nome, dose, freqüência de administração, indicações terapêuticas, tempo de uso de medicamentos, bem como a compreensão das informações verbais complementares. Dos entrevistados, 80,4% eram mães e 49,4% cursaram ensino fundamental. Quanto às informações recebidas durante a consulta e/ou dispensação...

Coverage and Awareness of and Compliance with Mass Drug Administration for Elimination of Lymphatic Filariasis in Burdwan District, West Bengal, India

Roy, Rabindra Nath; Sarkar, Aditya Prasad; Misra, Raghunath; Chakroborty, Amitava; Mondal, Tusar Kanti; Bag, Kanad
Fonte: International Centre for Diarrhoeal Disease Research, Bangladesh Publicador: International Centre for Diarrhoeal Disease Research, Bangladesh
Tipo: Artigo de Revista Científica
Publicado em /06/2013 Português
Relevância na Pesquisa
47.861016%
India adopted WHO's strategy of repeated rounds of mass drug administration (MDA) with diethylcarbamazine to eliminate lymphatic filariasis. The present study attempted to assess the coverage and awareness of and compliance with MDA for elimination of lymphatic filariasis in Burdwan district of India, following MDA round in July 2010. A cross-sectional study was conducted among the four randomly-selected clusters in the district of Burdwan, West Bengal, India, covering 603 individuals from 154 households, using a predesigned pretested schedule. The drug distribution coverage, compliance, and effective coverage were 48.76 %, 70.07%, and 34.16% respectively. Only 41.4% of the study population was aware of the MDA activity. This evaluation study noted that MDA is restricted to tablet distribution only. There is an urgent need to improve compliance with drug intake through strengthening of the awareness programme involving both government health workers and community volunteers.

Transtorno afetivo bipolar e a ambivalência em relação à terapia medicamentosa: analisando as condições causais; Transtorno afectivo bipolar y la ambivalencia en relación a la terapia medicamentosa: analizando las condiciones causales; Affective bipolar disorder and ambivalence in relation to the drug treatment: analyzing the causal conditions

Miasso, Adriana Inocenti; Cassiani, Silvia Helena De Bortoli; Pedrão, Luiz Jorge
Fonte: Universidade de São Paulo. Escola de Enfermagem Publicador: Universidade de São Paulo. Escola de Enfermagem
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Artigo Avaliado pelos Pares Formato: application/pdf; application/pdf
Publicado em 01/04/2011 Português
Relevância na Pesquisa
57.61783%
Este estudo buscou compreender as condições causais da ambivalência da pessoa com transtorno afetivo bipolar (TAB) em relação ao seguimento da terapêutica medicamentosa. Foi utilizada a abordagem qualitativa, tendo como referencial metodológico a Teoria Fundamentada nos Dados, à luz do Interacionismo Simbólico. Participaram do estudo 14 pessoas com TAB que estavam em acompanhamento em um Ambulatório de Transtornos do Humor de um hospital universitário e 14 familiares indicados pelas mesmas. A entrevista e observação foram as principais formas de obtenção de dados. Os resultados revelaram três categorias que descrevem as referidas condições causais: vivendo as crises do transtorno; tendo necessidade do medicamento e convivendo com os efeitos colaterais dos medicamentos. Este estudo aponta para necessidade de mudança de atitude dos profissionais de saúde de culpabilizar o paciente pela interrupção do tratamento para aquela de escuta, de valorização do seu universo simbólico e afetivo bem como de parceria no tratamento.; Estudio que buscó comprender las condiciones causales de ambivalencia de persona con transtorno afectivo bipolar (TAB) relacionadas al seguimiento de terapéutica medicamentosa. Utilizó abordaje cualitativa...

Schizophrenia: adherence to treatment and beliefs about the disorder and the drug treatment; Esquizofrenia: adhesión al tratamiento y creencias sobre el transtorno y terapéutica medicamentosa; Esquizofrenia: adesão ao tratamento e crenças sobre o transtorno e terapêutica medicamentosa

Nicolino, Paula Silva; Vedana, Kelly Graziani Giacchero; Miasso, Adriana Inocenti; Cardoso, Lucilene; Galera, Sueli Aparecida Frari
Fonte: Universidade de São Paulo. Escola de Enfermagem Publicador: Universidade de São Paulo. Escola de Enfermagem
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Artigo Avaliado pelos Pares Formato: application/pdf; application/pdf
Publicado em 01/06/2011 Português
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This study verified the adherence of people with schizophrenia to the medication, identified and compared their beliefs about the disorder and the drug among patients who adhered and those who did not. Participants were 14 patients of a psychiatric outpatient clinic. Semi-structured interviews and the Morisky-Green test were performed. The data was analyzed using a quali-quantitative approach. Results showed that 64.3% of patients do not adhere to treatment. Most participants considered the drug capable of reducing the seriousness and severity of the disorder. However, the drawbacks for patients that did not adhere to the treatment were more expressive. Side effects were the cause for interrupting the treatment for 80% of patients who intentionally did not adhere to treatment. It was observed there is insufficient knowledge about schizophrenia and the drug treatment. Patients referred to faith as a strategy to cope with the process they were experiencing. This study points at the need for strategies directed towards the promotion of drug treatment adherence among people with schizophrenia.; Estudio que verificó adhesión de personas esquizofrénicas a la medicación, identificó y comparó las creencias sobre transtorno y medicamento entre pacientes adherentes y no adherentes. Participaron 14 pacientes de ambulatorio de psiquiatría. Se realizó entrevista semiestructurada y aplicación de Test de Morisky-Green. Los datos se analizaron con abordaje cuali-cuantitativo. Los resultados revelaron que 64...