Página 1 dos resultados de 86216 itens digitais encontrados em 0.260 segundos

Structural study of the interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) in aqueous solution

Castro, M. M. C. A.; Geraldes, C. F. G. C.; Gameiro, P.; Pereira, E.; Castro, B.; Rangel, M.
Fonte: Universidade de Coimbra Publicador: Universidade de Coimbra
Tipo: Artigo de Revista Científica Formato: aplication/PDF
Português
Relevância na Pesquisa
76.393237%
The interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) was studied in aqueous solution using a combination of multinuclear NMR and EPR spectroscopies, as well as potentiometry and cyclic voltammetry. The different species in solution were identified and characterized, and their pKa values and stability constants determined. The vanadium complexes formed in solution are strongly dependent on media composition (ionic strength, presence of buffer), pH and metal-to-ligand ratio (M:L). Two major species -- V(V)/dmpp and V(V)/(dmpp)2 -- are formed in a 140 mM NaCl solution within the pH range 4.5 to 9.0, when M:L=1:2. In the presence of excess ligand (M:L<=1:5), only the 1:2 complex is present, and at pH<4 paramagnetic species are detected by EPR in solution, thus indicating a reducing capacity of the ligand. Cyclic voltammetry shows that redox processes in solution are not just electron transfer, but are accompanied by chemical reactions. The pKa values and stability constants were determined both by 51V NMR spectroscopy and potentiometry. The present results have a particular interest in the understanding of the aqueous solution chemistry in aerobic conditions of bis(1,2-dimethyl-3-hydroxy-4-pyridinonato) oxovanadium(IV) complex...

Solvation enthalpy and the thermodynamics of hydration of trans-cyclohexyl-1,4-diamine and cis-cyclohexyl-1,2-diamine

Tomé, Luciana I. N.; Jesus, A. J. Lopes; Castro, R. A. Esteves de; Teixeira, M. Helena S. F.; Canotilho, João; Eusébio, M. Ermelinda S.
Fonte: Universidade de Coimbra Publicador: Universidade de Coimbra
Tipo: Artigo de Revista Científica Formato: aplication/PDF
Português
Relevância na Pesquisa
76.300557%
The enthalpy of solution of trans-cyclohexyl-1,4-diamine and cis-cyclohexyl-1,2-diamine in water was determined by calorimetry. The enthalpy of hydration was determined from this quantity and from the enthalpy of sublimation/vaporization presented in another paper by the authors. Considering the solvation process resulting from cavity creation in the solvent and variation of solute conformation transfer steps, the enthalpy corresponding to solute-solvent interaction was estimated. The entropies of solvation and interaction were calculated from the values given for the enthalpies in the present paper and those available for the Gibbs free energies.; http://www.sciencedirect.com/science/article/B6WHM-4P7788D-1/1/08d12dc60548e86cd10853255d09209d

Synthesis of 5-alkynyl-2,2,6-trimethyl-1,3-dioxin-4-ones and 1,4-disubstituted-1,2,3-triazoles

STEFANI, Helio A.; VIEIRA, Adriano S.; AMARAL, Monica F. Z. J.; COOPER, Leora
Fonte: PERGAMON-ELSEVIER SCIENCE LTD Publicador: PERGAMON-ELSEVIER SCIENCE LTD
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
76.42921%
Herein we report an approach to the formation of 5-alkynyl-1,3-dioxin-4-ones using Suzuki-Miyaura cross-coupling reaction of potassium alkynyltrifluoroborate salts with 2,2,6-trimethy1-5-iodo-1,3-dioxin-4-one. The resulting 5-ethynyltrimethylsilyl-1,3-dioxin-4-ones obtained through the Sonogashira reaction were further reacted in a Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition to form functionalized 1,4-disubstituted-1,2,3-triazoles in good yields, using mild conditions and ultrasonic radiation to expedite the reaction. (C) 2011 Elsevier Ltd. All rights reserved.; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico[CNPq 300.613/2007-5]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo[FAPESP 06/50190-7]; FAPESP Fundacao de Amparo a Pesquisa do Estado de Sao Paulo[07/02382-7]; FAPESP Fundacao de Amparo a Pesquisa do Estado de Sao Paulo[07/59404-2]

Practical synthesis of a functionalized 1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Quintiliano, Samir A. P.; Silva, Luiz F., Jr.
Fonte: PERGAMON-ELSEVIER SCIENCE LTD; OXFORD Publicador: PERGAMON-ELSEVIER SCIENCE LTD; OXFORD
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
76.324473%
The synthesis of a functionalized 1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid has been performed in 10 steps from the readily available dimedone. Only three purifications by flash chromatography are required through the whole sequence. The key step is the reaction between a dimedone derivative and a chlorotetrolic ester, that gives a tetrasubstituted benzene ring (through a Diels-Alder/retro- Diels-Alder process) bearing the substituents in the suitable positions for further functionalization. (C) 2012 Elsevier Ltd. All rights reserved.; CNPq; FAPESP; CAPES

HIV-1/2 indeterminate Western blot results: follow-up of asymptomatic blood donors in Belo Horizonte, Minas Gerais, Brazil

CARNEIRO-PROIETTI,A.B.F.; CUNHA,I.W.; SOUZA,M.M.; OLIVEIRA,D.R.; MESQUITA,N.M.; ANDRADE,C.A.; CATALAN-SOARES,B.C.; LIMA-MARTINS,M.V.C.; PROIETTI,F.A.
Fonte: Instituto de Medicina Tropical Publicador: Instituto de Medicina Tropical
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/05/1999 Português
Relevância na Pesquisa
76.539014%
The clinical and public health importance of indeterminate results in HIV-1/2 testing is still difficult to evaluate in volunteer blood donors. At Fundação Hemominas, HIV-1/2 ELISA is used as the screening test and, if reactive, is followed by Western blot (WB). We have evaluated 84 blood donors who had repeatedly reactive ELISA tests for HIV-1/2, but indeterminate WB results. Sixteen of the 84 donors (19.0%) had history of sexually transmitted diseases; 18/84 (21.4%) informed receiving or paying for sex; 3/84 (3.6%) had homosexual contact; 2/26 women (7.6%) had past history of multiple illegal abortions and 3/84 (3.6%) had been previously transfused. Four out of 62 donors (6.5%) had positive anti-nuclear factor (Hep2), with titles up to 1:640. Parasitological examination of the stool revealed eggs of S. mansoni in 4/62 (6.4%) donors and other parasites in 8/62 (12.9%). Five (5.9%) of the subjects presented overt seroconversion for HIV-1/2, 43/84 (51.2%) had negative results on the last visit, while 36/84 (42.9%) remained WB indeterminate. Although some conditions could be found associated with the HIV-1/2 indeterminate WB results and many donors had past of risky behavior, the significance of the majority of the results remains to be determined.

Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas

Melo,Júlio O. F.; Donnici,Claudio Luis; Augusti,Rodinei; Ferreira,Vitor F.; Souza,Maria Cecília B. V. de; Ferreira,Maria Lourdes G.; Cunha,Anna C.
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2006 Português
Relevância na Pesquisa
76.48215%
The 1,2,3-triazole, known since the end of 19th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds. In fact, 1,2,3-triazoles show several applications in many areas especially as medicines against many diseases like cancer, AIDS, Parkinson and Alzheimer. Nowadays there is a large variety of known methods to obtain these heterocyclic compounds comprising mainly three synthetic routes. Nevertheless, there is no article that gives an objective overview of the synthetic methods for obtaining these kinds of azoheterocycles. This paper presents a brief history of this class of compounds, and a synthetic discussion concerning the main synthetic methods for its preparation, such as cyclization through hydrazones, concerted cycloadditon [2+3] and pseudopericyclic cyclization - and some others of restricted application, but also important. Finally, this paper also provides a brief overview on pharmacological applications of some 1,2,3-triazoles.

Aspectos virológicos e clínico-patológicos da infecção genital aguda e latente pelo herpesvírus bovino tipo 1.2 em bezerras infectadas experimentalmente

Henzel,Andréia; Diel,Diego G.; Arenhart,Sandra; Vogel,Fernanda S. Flores; Weiblen,Rudi; Flores,Eduardo F.
Fonte: Colégio Brasileiro de Patologia Animal - CBPA; Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Publicador: Colégio Brasileiro de Patologia Animal - CBPA; Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2008 Português
Relevância na Pesquisa
76.36273%
A infecção genital de vacas pelo herpesvírus bovino tipo 1.2 (BoHV-1.2) pode resultar em vulvovaginite e infertilidade temporária. Após a infecção aguda, o BoHV-1 estabelece infecção latente, que pode cursar com episódios periódicos de reativação. O presente trabalho descreve os aspectos virológicos e clínico-patológicos da vulvovaginite aguda e infecção latente resultantes da inoculação de bezerras com uma amostra de BoHV-1.2 isolada de casos de balanopostite em touros. A inoculação do vírus em quatro bezerras pela via genital (10(8.1)TCID50/animal) resultou em replicação viral na mucosa genital e no desenvolvimento de vulvovaginite moderada a severa. Os animais inoculados excretaram o vírus nas secreções genitais até o dia 10 pós-inoculação (p.i.) com título máximo de 10(7.3)TCID50/mL. Foram observados congestão e edema da mucosa vulvovestibular, e formação de pequenas vesículas e pústulas. Durante a progressão clínica, as vesículas e pústulas aumentaram de tamanho e eventualmente se tornaram coalescentes e recobertas por um exsudato fino de coloração amarelada. Estes sinais foram observados a partir do dia 2 p.i. e aumentaram progressivamente de severidade até os dias 5-8 p.i. A administração de dexametasona no dia 55 p.i. resultou em excreção viral nas secreções genitais dos quatro animais por até 10 dias. A reativação da infecção latente foi acompanhada de recrudescência clínica...

Synthesis and evaluation of 1-alkyl-4-phenyl-[1,2,3]-triazole derivatives as antimycobacterial agent

Gallardo,Hugo; Conte,Gilmar; Bryk,Fernando; Lourenço,Maria Cristina S.; Costa,Marilia S.; Ferreira,Vitor F.
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2007 Português
Relevância na Pesquisa
76.355566%
Fourteen small molar mass 1-alkyl-4-phenyl-[1,2,3]-triazole derivatives were prepared using a straightforward and efficient method for the regioselective synthesis of [1,2,3]-triazoles and the compounds were screened for antimycobacterial activity against multiple-drug-resistant strains of Mycobacterium tuberculosis H37Rv. The synthetic methodology consisted of a Cu(I)-catalyzed 1,3-dipolar cycloaddition of aryl azides to terminal arylacetylenes (click-reaction). Six [1,2,3]-triazoles were found to be more active against M. tuberculosis than the positive control ethambutol.

Western blot seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) in Fortaleza (Brazil): a serological and molecular diagnostic and epidemiological approach

Santos,Terezinha de Jesus Teixeira; Costa,Carlos Maurício de Castro; Goubau,Patrick; Vandamme,Anne-Mieke; Desmyter,Jan; Van Dooren,Sonia; Mota,Rosa M. S.; Costa,Francine Bovy de Castro; Oliveira,Ana C. S.; Gomes,Vânia Barreto A.F.; Carneiro-Proietti,Ann
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2003 Português
Relevância na Pesquisa
76.374863%
How to handle Western blot (WB) seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) constitutes a challenge for blood banks and fam ilies. We made a cross-sectional study of 191 enzyme linked immunoassay (EIA) reactive individuals from the hematological center (HEMOCE) of Fortaleza (Brazil), examining their serological (WB) and molecular (PCR) diagnosis, and demographic profiles, as well as a possible association of their condition with other infectious pathologies and risk factors. Ethical institutional approval and personal consent were obtained. Out of 191 EIA reactive individuals, 118 were WB seroindeterminate and 73 were seropositive for HTLV-1/2. In the PCR analysis of 41 WB seroindeterminate individuals, 9 (22%) were positive and 32 (78%) were negative for HTLV-1/2. The demographic analysis indicated a trend towards a predominance of males among the seroindeterminate individuals and females in the seropositive ones. The seroindeterminate individuals were younger than the seropositive ones. We did not find any association of these conditions with syphilis, Chagas disease or HIV or hepatitis, and with risk factors such as breast-feeding, blood transfusion, STD (syphilis) and IDU.

Fragmento 1+2 da protrombina em indivíduos submetidos à angiografia coronariana

Lima,Luciana M.; Sousa,Marinez O.; Fernandes,Ana P.; Loures-Vale,Andréia A.; Fonseca Neto,Cirilo P.; Garcia,José C. F.; Saad,Jamil A.; Carvalho,Maria G.
Fonte: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Publicador: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2005 Português
Relevância na Pesquisa
76.32045%
A trombina exerce um papel fundamental na conversão do fibrinogênio em fibrina, no processo de coagulação. O fator X ativado transforma a protrombina em trombina e fragmento 1+2 da protrombina (F1+2). Os níveis plasmáticos de F1+2 refletem a geração de trombina e podem ser usados como um marcador de hipercoagulabilidade in vivo, já que a trombina é uma substância instável e facilmente degradada, que não pode ser medida diretamente no plasma. O presente estudo teve como objetivo determinar os níveis plasmáticos do F1+2 de um grupo de indivíduos submetidos à angiografia coronariana, buscando estabelecer a possível correlação entre este parâmetro e a gravidade da doença arterial coronariana (DAC). Os níveis plasmáticos do F1+2 foram determinados em amostras de sangue de 17 indivíduos com ausência de ateromatose nas coronárias (controles), 12 indivíduos apresentando ateromatose leve/moderada e 28 indivíduos apresentando ateromatose grave, utilizando-se o conjunto diagnóstico Enzignost F1+2 (Behring® Diagnostics GmbH, Marburg, Germany). Não foram encontradas diferenças estatisticamente significativas entre as médias dos três grupos para o parâmetro avaliado. Portanto, as médias obtidas nos três grupos para os níveis plasmáticos de F1+2 não sinalizam para a existência de um estado de hipercoagulabilidade na população estudada. Entretanto...

Les esters cyclopropane-1,1-dicarboxyliques et les dérivés cyclopropaniques 1,2,3-substitués : synthèses et applications

Goudreau, Sébastien R.
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
Relevância na Pesquisa
76.676704%
Les cyclopropanes sont des motifs d’une grande importance puisqu’ils sont présents dans plusieurs molécules biologiquement actives en plus d’être de puissants intermédiaires dans la synthèse de molécules complexes. Au cours de cet ouvrage, nous avons développé une nouvelle méthode générale pour la synthèse d’ylures d’iodonium de malonates, soit d’importants précurseurs d’esters cyclopropane-1,1-dicarboxyliques. Ainsi, à l’aide de ces ylures, une méthode très efficace pour la synthèse d’esters cyclopropane-1,1-dicarboxyliques racémiques a été développée. Des travaux ont aussi été entrepris pour la synthèse énantiosélective de ces composés. Par ailleurs, les esters cyclopropane-1,1-dicarboxyliques ont été utilisés dans le développement de deux nouvelles méthodologies, soit dans une réaction de cycloaddition (3+3) avec des imines d’azométhines et dans la formation d’allènes par l’addition-1,7 de cuprates. Nous avons aussi poursuivi l’étude synthétique du cylindrocyclophane F impliquant l’utilisation de cyclopropanes pour le contrôle des centres chiraux. Ainsi l’addition-1,5 d’un cuprate sur un ester cyclopropane-1,1-dicarboxylique a été utilisée comme l’une des étapes clés de notre synthèse. L’autre centre chiral a pu être contrôlé par l’hydrogénolyse sélective d’un cyclopropylméthanol. Ces études ont...

2-Alkoxycarbonylcycloimmonium ylides, efficient 1,4-dipole equivalents in the synthesis of new conjugated betaines

Cuadro Palacios, Ana María; Valenciano Martínez, Jesús; Vaquero López, Juan José; García Navío, José Luis; Álvarez-Builla Gómez, Julio
Fonte: Pergamon Publicador: Pergamon
Tipo: info:eu-repo/semantics/article; PeerReviewed Formato: application/pdf
Português
Relevância na Pesquisa
76.53013%
Several heterocyclic mesomeric betaines containing the bicyclic systems pyrido[1,2-a]pyrazine and pyrido [2,1-f][1,2,4]triazine have been prepared by reaction of 2-alkoxycarbonyl pyridinium N-ylides with phenyl isocyanate and isothiocyanate.

Metal-free synthesis of indanes by iodine(III)-mediated ring contraction of 1, 2-dihydronaphthalenes

SIQUEIRA, Fernanda A; ISHIKAWA, Eloisa E; FOGAÇA, André; FACCIO, Andréa T; CARNEIRO, Vânia M. T; SOARES, Rafael R. S; UTAKA, Aline; TÉBÉKA, Iris R. M; BIELAWSKI, Marcin; OLOFSSON, Berit; SILVA JR, Luiz F
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
76.43589%
A metal-free protocol was developed to synthesize indanes by ring contraction of 1, 2-dihydronaphthalenes promoted by PhI(OH)OTs (HTIB or Koser's reagent). This oxidative rearrangement can be performed in several solvents (MeOH, CH3CN, 2 , 2, 2-trifluoroethanol (TFE), 1 , 1, 1, 3, 3, 3-hexafluoroisopropanol (HFIP), and a 1:4 mixture of TFE:CH2Cl2) under mild conditions. The ring contraction diastereoselectively gives functionalized trans-1, 3-disubstituted indanes, which are difficult to obtain in synthetic organic chemistry; Um protocolo livre de metais foi desenvolvido para sintetizar indanos através da contração de anel de 1, 2-di-hidronaftalenos promovida por PhI(OH)OTs (HTIB ou reagente de Koser). Este rearranjo oxidativo pode ser realizado em diversos solventes (MeOH, CH3CN, 2 , 2, 2-trifluoroetanol (TFE), 1 , 1, 1, 3, 3, 3-hexafluoroisopropanol (HFIP), e uma mistura 1:4 de TFE:CH2Cl2) em condições brandas. A contração de anel fornece indanos trans-1, 3-dissubstituídos diastereosseletivamente, os quais são difíceis de obter em química orgânica sintética; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); FAPESP

Evaluation of the marker of hypercoagulability prothrombin fragment F 1+2 in patients with mechanical or biological heart valve prostheses

Ferreira,Claudia Natália; Vieira,Lauro Mello; Dusse,Luci Maria Sant'Ana; Amaral,Carlos Faria Santos; Esteves,William Antônio de Magalhães; Fenelon,Lúcia Maria Amorim; Carvalho,Maria das Graças
Fonte: Sociedade Brasileira de Cardiologia - SBC Publicador: Sociedade Brasileira de Cardiologia - SBC
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/11/2002 Português
Relevância na Pesquisa
76.284917%
OBJECTIVE: To investigate whether patients with heart valve prostheses and similar International Normalized Ratios (INR) have the same level of protection against thromboembolic events, that is, whether the anticoagulation intensity is related to the intensity of hypercoagulability supression. METHODS: INR and plasma levels of prothrombin fragment 1+2 (F1+2) were assessed in blood samples of 27 patients (7 with mechanical heart valves and 20 with biological heart valves) and 27 blood samples from healthy donors that were not taking any medication. RESULTS: Increased levels of F1+2 were observed in blood samples of 5 patients with heart valve prostheses taking warfarin. These findings reinforce the idea that even though patients may have INRs, within the therapeutic spectrum, they are not free from new thromboembolic events. CONCLUSION: Determination of the hypercoagulability marker F1+2 might result in greater efficacy and safety for the use of oral anticoagulants, resulting in improved quality of life for patients.

Prevalence of HIV-1/2, HTLV-I/II, hepatitis B virus (HBV), hepatitis C virus (HCV), Treponema pallidum and Trypanosoma cruzi among prison inmates at Manhuaçu, Minas Gerais State, Brazil

Catalan-Soares,Bernadette Corrêa; Almeida,Regina Toledo P.; Carneiro-Proietti,Anna Bárbara F.
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2000 Português
Relevância na Pesquisa
76.36273%
The purpose of this study was to determine the seroprevalence of human immunodeficiency virus (HIV-1/2), human T-cell lymphotropic virus (HTLV-I/II), hepatitis B virus (HBV), hepatitis C virus (HCV), Treponema pallidum and Trypanosoma cruzi among 63 male prisoners in Manhuaçu, Minas Gerais, Brazil and to compare this with data from eligible blood donors. The positive results were as follows: 11/63 (17.5%) for HBV, 5/63 (7.4%) for syphilis, 4/63 (6.3%) for HCV, 3/63 (4.8%) for Chagas' disease, 2/63 (3.2%) for HIV-1/2 and 1/63 (1.6%) for HTLV-I/II. The seroprevalence in prisoners was higher than among blood donors, mainly for antibodies to HIV-1/2, HCV and HBV. This is probably due to low social economic level, illiteracy, higher proportion with a prior history of intravenous drug use and/or unsafe sexual behavior. Therefore, these prisoners constitute a high risk group and routine screening and counseling are recommended.

Utilização de parte da região codificadora da glicoproteína b na diferenciação do herpesvírus bovino 1.1, herpesvírus bovino 1.2 e herpesvírus bovino 5

Costa,E.A.; Barbosa-Stancioli,E.F.; Leite,R.C.; Oliveira,G.D.R.; Rocha,M.A.
Fonte: Universidade Federal de Minas Gerais, Escola de Veterinária Publicador: Universidade Federal de Minas Gerais, Escola de Veterinária
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2005 Português
Relevância na Pesquisa
76.37301%
Utilizou-se uma reação em cadeia de polimerase (PCR) previamente desenvolvida para a amplificação de parte da região única longa 27 (UL27) do genoma de herpesvírus bovino 1.1 (BoHV-1), que codifica a glicoproteína B, buscando a diferenciação entre isolados de BoHV-1.1 e BoHV-5. Os produtos de PCR gerados a partir de isolados de BoHV-1.1 e BoHV-5 mostraram padrão de amplificação diferenciado em seus tamanhos moleculares. Analisando as seqüências de nucleotídeos dos produtos de PCR obtidos de dois isolados de BoHV-5, juntamente com as seqüências dos produtos de PCR obtidos de um isolado de BoHV-1.1 e de três isolados de BoHV-1.2, previamente depositados no GenBank, verificou-se que a diferença observada na amplificação se deve ao número de repetições de G-C presentes no final da região codificadora da gB, particularmente nas seqüências 5'-G(A/T)CC-3'. A análise dessas seqüências-motivo desponta como uma ferramenta auxiliar na diferenciação entre isolados de BoHV-1.1, BoHV-1.2 e BoHV-5.

Metal-free synthesis of indanes by iodine(III)-mediated ring contraction of 1, 2-dihydronaphthalenes

Siqueira,Fernanda A; Ishikawa,Eloisa E; Fogaça,André; Faccio,Andréa T; Carneiro,Vânia M. T; Soares,Rafael R. S; Utaka,Aline; Tébéka,Iris R. M; Bielawski,Marcin; Olofsson,Berit; Silva Jr,Luiz F
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2011 Português
Relevância na Pesquisa
76.37161%
A metal-free protocol was developed to synthesize indanes by ring contraction of 1, 2-dihydronaphthalenes promoted by PhI(OH)OTs (HTIB or Koser's reagent). This oxidative rearrangement can be performed in several solvents (MeOH, CH3CN, 2 , 2, 2-trifluoroethanol (TFE), 1 , 1, 1, 3, 3, 3-hexafluoroisopropanol (HFIP), and a 1:4 mixture of TFE:CH2Cl2) under mild conditions. The ring contraction diastereoselectively gives functionalized trans-1, 3-disubstituted indanes, which are difficult to obtain in synthetic organic chemistry

Synthesis of novel isatin-type 5'-(4-Alkyl/Aryl-1H-1,2,3-triazoles) via 1,3-dipolar cycloaddition reactions

Silva,Bianca N. M.; Silva,Bárbara V.; Silva,Fernando C.; Gonzaga,Daniel T. G.; Ferreira,Vitor F.; Pinto,Angelo C.
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2013 Português
Relevância na Pesquisa
76.324473%
Isatin and 1H-1,2,3-triazoles are two classes of compounds with great prominence in organic synthesis and medicinal chemistry as they are heterocycle nuclei with a high reactivity allowing to obtain several compounds with important biological properties. Herein, the synthesis of novel 5'-(4-alquil/aril-1H-1,2,3-triazole)-isatin via reaction of 1,3-dipolar cycloaddition catalyzed by acetic acid is reported.

Synthesis of [123l] iodine labelled imidazo [1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT

Katsifis, Andrew; Barlin, Gordon; Mattner, F; Dikic, Branko
Fonte: Oldenbourg Wissenschaftsverlag Publicador: Oldenbourg Wissenschaftsverlag
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
76.43402%
The pyridazines 3-acetamidomethyl-6-chloro-2-(4′-iodophenyl) imidazo[1,2-b]pyridazine 1 (IC50 = 1.6 nM) and 3-benzanfidomethyl-6- iodo-2-(4′-t-butylphenyl)imidazo[1,2-b] pyridazine 2 (IC50 = 4.2 nM), are high affinity and selective ligands for the Per

1,2,4-Oxadiazóis: Síntese e Aplicações; 1,2,4-Oxadiazoles: Synthesis and Applications

Jucleiton José R. de Freitas; Universidade Federal Rural de Pernambuco; Edilma Elayne da Silva; Universidade Federal Rural de Pernambuco; Juliana L. L. F. Regueira; Universidade Federal Rural de Pernambuco; Suelâeny A. de Andrade; Universidade Federal R
Fonte: Revista Virtual de Química Publicador: Revista Virtual de Química
Tipo: ; Formato: binary/octet-stream
Publicado em 25/12/2012 Português
Relevância na Pesquisa
76.408013%
1,2,4-oxadiazóis são compostos que têm atraído a atenção de muitos pesquisadores devido à sua ampla gama de atividades biológicas. Métodos empregados na síntese de 1,2,4-oxadiazóis 3,5-substituídos são revistos, neste trabalho, bem como a aplicação destes compostos. As sínteses são baseadas, principalmente, na utilização de amidoximas primárias e agentes de acilação como os reagentes iniciais. Nos últimos anos, vários relatos sobre novas metodologias de síntese deste heterociclo foram publicadas na literatura. A aplicação da irradiação de micro-ondas e ultrassom na síntese química apresenta muitas vantagens com consequentes impactos sobre a economia e o meio ambiente. DOI: 10.5935/1984-6835.20120051; 1,2,4-Oxadiazole are compounds that have attracted the attention of many researchers due to their wide range of biological activities. Methods used for the synthesis of 3,5-substituted 1,2,4-oxadiazoles are reviewed in this works, as well as their applications. The syntheses are based mostly on the use of primary amidoximes and acylating agents as the initial reactants.  In the last years, numerous reports concerning new methods of synthesis of 1,2,4-oxadiazoles have been reported. The use of microwave irradiation and ultrasound in chemical synthesis has many advantages with consequent impacts on the economy and the environment. DOI: 10.5935/1984-6835.20120051