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Introduction

Rothberg, Jonathan; Merriman, Barry; Higgs, Gadareth
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
59.220664%

Development of an Undergraduate Bioinformatics Degree Program at a Liberal Arts College

Bagga, Paramjeet S.
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
80.030605%
The highly interdisciplinary field of bioinformatics has emerged as a powerful modern science. There has been a great demand for undergraduate- and graduate-level trained bioinformaticists in the industry as well in the academia. In order to address the needs for trained bioinformaticists, its curriculum must be offered at the undergraduate level, especially at four-year colleges, where a majority of the United States gets its education. There are many challenges in developing an undergraduate-level bioinformatics program that needs to be carefully designed as a well-integrated and cohesive interdisciplinary curriculum that prepares the students for a wide variety of career options. This article describes the challenges of establishing a highly interdisciplinary undergraduate major, the development of an undergraduate bioinformatics degree program at Ramapo College of New Jersey, and lessons learned in the last 10 years during its management.

Thriving in Multidisciplinary Research: Advice for New Bioinformatics Students

Auerbach, Raymond K.
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
90.03678%
The sciences have seen a large increase in demand for students in bioinformatics and multidisciplinary fields in general. Many new educational programs have been created to satisfy this demand, but navigating these programs requires a non-traditional outlook and emphasizes working in teams of individuals with distinct yet complementary skill sets. Written from the perspective of a current bioinformatics student, this article seeks to offer advice to prospective and current students in bioinformatics regarding what to expect in their educational program, how multidisciplinary fields differ from more traditional paths, and decisions that they will face on the road to becoming successful, productive bioinformaticists.

Perspectives on an Education in Computational Biology and Medicine

Rubinstein, Jill C.
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
79.652393%
The mainstream application of massively parallel, high-throughput assays in biomedical research has created a demand for scientists educated in Computational Biology and Bioinformatics (CBB). In response, formalized graduate programs have rapidly evolved over the past decade. Concurrently, there is increasing need for clinicians trained to oversee the responsible translation of CBB research into clinical tools. Physician-scientists with dedicated CBB training can facilitate such translation, positioning themselves at the intersection between computational biomedical research and medicine. This perspective explores key elements of the educational path to such a position, specifically addressing: 1) evolving perceptions of the role of the computational biologist and the impact on training and career opportunities; 2) challenges in and strategies for obtaining the core skill set required of a biomedical researcher in a computational world; and 3) how the combination of CBB with medical training provides a logical foundation for a career in academic medicine and/or biomedical research.

Systematic Deciphering of Cancer Genome Networks

Fendler, Bernard; Atwal, Gurinder
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
69.274224%
When growth regulatory genes are damaged in a cell, it may become cancerous. Current technological advances in the last decade have allowed the characterization of the whole genome of these cells by directly or indirectly measuring DNA changes. Complementary analyses were developed to make sense of the massive amounts of data generated. A large majority of these analyses were developed to construct interaction networks between genes from, primarily, expression array data. We review the current technologies and analyses that have developed in the last decade. We further argue that as cancer genomics evolves from single gene validations to gene network inferences, new analyses must be developed for the different technological platforms.

Integrated Analysis of Tumor Samples Sheds Light on Tumor Heterogeneity

Parisi, Fabio; Micsinai, Mariann; Strino, Francesco; Ariyan, Stephan; Narayan, Deepak; Bacchiocchi, Antonella; Cheng, Elaine; Xu, Fang; Li, Peining; Kluger, Harriet; Halaban, Ruth; Kluger, Yuval
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
69.285137%
The heterogeneity of tumor samples is a major challenge in the analysis of high-throughput profiling of tumor biopsies and cell lines. The measured aggregate signals of multigenerational progenies often represent an average of several tumor subclones with varying genomic aberrations and different gene expression levels. The goal of the present study was to integrate copy number analyses from SNP-arrays and karyotyping, gene expression profiling, and pathway analyses to detect heterogeneity, identify driver mutations, and explore possible mechanisms of tumor evolution. We showed the heterogeneity of the studied samples, characterized the global copy number alteration profiles, and identified genes whose copy number status and expression levels were aberrant. In particular, we identified a recurrent association between two BRAFV600E and BRAFV600K mutations and changes in DKK1 gene expression levels, which might indicate an association between the BRAF and WNT pathways. These findings show that the integrated approaches used in the present study can robustly address the challenging issue of tumor heterogeneity in high-throughput profiling.

The Future of Medical Diagnostics: Large Digitized Databases

Kerr, Wesley T.; Lau, Edward P.; Owens, Gwen E.; Trefler, Aaron
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
69.264873%
The electronic health record mandate within the American Recovery and Reinvestment Act of 2009 will have a far-reaching affect on medicine. In this article, we provide an in-depth analysis of how this mandate is expected to stimulate the production of large-scale, digitized databases of patient information. There is evidence to suggest that millions of patients and the National Institutes of Health will fully support the mining of such databases to better understand the process of diagnosing patients. This data mining likely will reaffirm and quantify known risk factors for many diagnoses. This quantification may be leveraged to further develop computer-aided diagnostic tools that weigh risk factors and provide decision support for health care providers. We expect that creation of these databases will stimulate the development of computer-aided diagnostic support tools that will become an integral part of modern medicine.

How the Electronic Health Record Will Change the Future of Health Care

Ronquillo, Jeremiah Geronimo
Fonte: YJBM Publicador: YJBM
Tipo: Artigo de Revista Científica
Publicado em 25/09/2012 Português
Relevância na Pesquisa
69.288594%
Genetic testing is expected to play a critical role in patient care in the near future. Advances in genomic research have the potential to impact medicine in very tangible and direct ways, from carrier screening to disease diagnosis and prognosis to targeted treatments and personalized medicine. However, numerous barriers to widespread adoption of genetic testing continue to exist, and health information technology will be a critical means of addressing these challenges. Electronic health records (EHRs) are a digital replacement for the traditional paper-based patient chart designed to improve the quality of patient care. EHRs have become increasingly essential to managing the wealth of existing clinical information that now includes genetic information extracted from the patient genome. The EHR is capable of changing health care in the future by transforming the way physicians use genomic information in the practice of medicine.