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Quantitative trait loci associated with the immune response to a bovine respiratory syncytial virus vaccine

Leach, R.J.; O'Neill, R.G.; Fitzpatrick, J.L.; Williams, J.L.; Glass, E.J.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
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Infectious disease is an important problem for animal breeders, farmers and governments worldwide. One approach to reducing disease is to breed for resistance. This linkage study used a Charolais-Holstein F2 cattle cross population (n = 501) which was genotyped for 165 microsatellite markers (covering all autosomes) to search for associations with phenotypes for Bovine Respiratory Syncytial Virus (BRSV) specific total-IgG, IgG1 and IgG2 concentrations at several time-points pre- and post-BRSV vaccination. Regions of the bovine genome which influenced the immune response induced by BRSV vaccination were identified, as well as regions associated with the clearance of maternally derived BRSV specific antibodies. Significant positive correlations were detected within traits across time, with negative correlations between the pre- and post-vaccination time points. The whole genome scan identified 27 Quantitative Trait Loci (QTL) on 13 autosomes. Many QTL were associated with the Thymus Helper 1 linked IgG2 response, especially at week 2 following vaccination. However the most significant QTL, which reached 5% genome-wide significance, was on BTA 17 for IgG1, also 2 weeks following vaccination. All animals had declining maternally derived BRSV specific antibodies prior to vaccination and the levels of BRSV specific antibody prior to vaccination were found to be under polygenic control with several QTL detected.Heifers from the same population (n = 195) were subsequently immunised with a 40-mer Foot-and-Mouth Disease Virus peptide (FMDV) in a previous publication. Several of these QTL associated with the FMDV traits had overlapping peak positions with QTL in the current study...

The optimal SAM surface functional group for producing a biomimetic HA coating on Ti

Liu, D.; Majewski, P.; O'Neill, B.; Ngothai, Y.; Colby, C.
Fonte: John Wiley & Sons, Inc. Publicador: John Wiley & Sons, Inc.
Tipo: Artigo de Revista Científica
Publicado em //2006 Português
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D. P. Liu, P. Majewski, B. K. O’Neill, Y. Ngothai and C. B. Colby

Structural plasticity in the oestrogen receptor ligand-binding domain

Nettles, K.; Bruning, J.; Gil, G.; O'Neill, E.; Nowak, J.; Hughs, A.; Kim, Y.; DeSombre, E.; Dilis, R.; Hanson, R.; Joachimiak, A.; Greene, G.
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
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The steroid hormone receptors are characterized by binding to relatively rigid, inflexible endogenous steroid ligands. Other members of the nuclear receptor superfamily bind to conformationally flexible lipids and show a corresponding degree of elasticity in the ligand-binding pocket. Here, we report the X-ray crystal structure of the oestrogen receptor α (ERα) bound to an oestradiol derivative with a prosthetic group, ortho- trifluoromethlyphenylvinyl, which binds in a novel extended pocket in the ligand-binding domain. Unlike ER antagonists with bulky side groups, this derivative is enclosed in the ligand-binding pocket, and acts as a potent agonist. This work shows that steroid hormone receptors can interact with a wider array of pharmacophores than previously thought through structural plasticity in the ligand-binding pocket.; Kendall W. Nettles, John B. Bruning, German Gil, Erin E. O’Neill, Jason Nowak, Alun Hughs, Younchang Kim, Eugene R. DeSombre, Robert Dilis, Robert N. Hanson, Andrzej Joachimiak & Geoffrey L. Greene

Repeated intrathecal injections of recombinant human 4-sulphatase remove dural storage in mature mucopolysaccharidosis VI cats primed with a short-course tolerisation regimen

Auclair, D.; Finnie, J.; White, J.; Nielsen, T.; Fuller, M.; Kakkis, E.; Cheng, A.; O'Neill, C.; Hopwood, J.
Fonte: Academic Press Inc Elsevier Science Publicador: Academic Press Inc Elsevier Science
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
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All MPS-VI cats treated thus far with weekly intravenous enzyme replacement therapy (IV ERT) with recombinant human N-acetylgalactosamine-4-sulphatase (rhASB) from 3 months of age onwards developed circulating anti-rhASB antibodies. In view of this, the possibility of inducing immune tolerance by using a short-course tolerisation regimen was tested. Starting at 4 months of age, MPS-VI (n=5) and unaffected cats (n=2) received cyclosporine and azathioprine over a 22-day period plus weekly IV ERT with 0.1mg/kg rhASB. After a 4-week resting period, these cats were administered weekly IV ERT with 1mg/kg rhASB until 11 or 17 months of age. Four unaffected cats (n=4) received weekly IV ERT only. Health, growth and seroconversion were regularly monitored. Four out of five MPS-VI cats tolerated rhASB well, as indicated by negligible or low antibody titres and absence of hypersensitivity reactions. One MPS-VI cat exhibited elevated antibody titres and hypersensitivity reactions during some IV treatments. The two unaffected cats that received the tolerisation regimen remained seronegative, however, only half of the unaffected cats not submitted to this regimen seroconverted. Only minor side-effects were attributed to the short-course of cyclosporine and azathioprine. Two MPS-VI cats also well-tolerated four weekly intrathecal injections of rhASB and consequently exhibited less oligosaccharide fragments in cerebrospinal fluid and less vacuolation within their dura mater. These data indicate that a relatively high rate of immunotolerance towards rhASB can be achieved in MPS-VI cats with a short-course tolerisation regimen ultimately permitting removal of lysosomal storage within the dura mater with the use of intrathecal therapy.; Dyane Auclair...

More than mere numbers: The impact of lethal control on the social stability of a top-order predator

Wallach, A.; Ritchie, E.; Read, J.; O'Neill, A.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em //2009 Português
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Population control of socially complex species may have profound ecological implications that remain largely invisible if only their abundance is considered. Here we discuss the effects of control on a socially complex top-order predator, the dingo (Canis lupus dingo). Since European occupation of Australia, dingoes have been controlled over much of the continent. Our aim was to investigate the effects of control on their abundance and social stability. We hypothesized that dingo abundance and social stability are not linearly related, and proposed a theoretical model in which dingo populations may fluctuate between three main states: (A) below carrying capacity and socially fractured, (B) above carrying capacity and socially fractured, or (C) at carrying capacity and socially stable. We predicted that lethal control would drive dingoes into the unstable states A or B, and that relaxation of control would allow recovery towards C. We tested our predictions by surveying relative abundance (track density) and indicators of social stability (scent-marking and howling) at seven sites in the arid zone subject to differing degrees of control. We also monitored changes in dingo abundance and social stability following relaxation and intensification of control. Sites where dingoes had been controlled within the previous two years were characterized by low scent-marking activity...

Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal women - a randomized trial

Davis, S.; Papalia, M.A.; Norman, R.; O'Neill, S.; Redelman, M.; Williamson, M.; Stuckey, B.; Wlodarzcyk, J.; Gard'ner, K.; Humberstone, A.
Fonte: Amer Coll Physicians Publicador: Amer Coll Physicians
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
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BACKGROUND: It is not known whether premenopausal women who report low sexual satisfaction and have low circulating testosterone levels will benefit from testosterone therapy. OBJECTIVE: To evaluate the effects of exogenous testosterone in premenopausal women reporting diminished sexual function. DESIGN: Randomized, double-blind, placebo-controlled, dose-ranging trial. SETTING: 6 Australian medical centers. PATIENTS: 261 women age 35 to 46 years who reported a decrease in satisfying sexual activity relative to their younger years and had a morning serum free testosterone level less than 3.8 pmol/L (<1.1 pg/mL). INTERVENTION: 3 different doses of testosterone administered by a metered-dose transdermal spray for 16 weeks or placebo. MEASUREMENTS: The primary outcome was the mean number of self-reported satisfactory sexual events (SSEs) over 28 days at week 16. The frequency of SSEs, total number of sexual events (every 4 weeks), scores from the modified Sabbatsberg Sexual Self-Rating Scale and the Psychological General Well-Being Index, and safety variables were also measured. RESULTS: The number of SSEs increased during the treatment period in the active treatment groups and the placebo group. The mean number of SSEs over 28 days at week 16 was statistically significantly greater for women treated with the intermediate dose of testosterone therapy (one 90-microL spray) than for women treated with placebo. The least-squares mean was 2.48 versus 1.70 SSEs...

Dealing with a social externality - alcohol and health

Powrie, I.; O'Neill, B.; Merrick, J.; Powrie, S.
Fonte: Taylor & Francis Publicador: Taylor & Francis
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
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Public awareness of illness resulting from the harmful consumption of alcohol is increasing. Public-health reaction has been to determine types of health problems, treatments and interventions. Work is continuing at international and national levels, supported by research leading to policy and cooperative public-health developments. The proportionality of the response by the alcoholic beverages industry has been questioned. The business risks are wide ranging principally due to a less than fully professional managerial response to existing concerns and pressure for more general interventions. The Australian wine industry response to this form of externality has been to meet regulatory requirements. It also cooperates with national market interventions, but as far as possible on a ‘self-regulatory’ basis. Their approach is similar to that taken by the international alcohol and tobacco industries consisting of a low-level contribution. The opportunity to create a more holistic strategy to improve both public-health and business outcomes is examined including identification of variables towards a cost–benefit analysis. The differentiated situation of ‘small and medium’ enterprises is considered. Failing any new initiatives, by the industry...

Intrathecal recombinant human 4-sulfatase reduces accumulation of glycosaminoglycans in dura of mucopolysaccharidosis VI cats

Auclair, D.; Finnie, J.; Walkley, S.; White, J.; Nielsen, T.; Fuller, M.; Cheng, A.; O'Neill, C.; Hopwood, J.
Fonte: Int Pediatric Research Foundation Inc Publicador: Int Pediatric Research Foundation Inc
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
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INTRODUCTION: Mucopolysaccharidosis VI (MPS-VI) is caused by a deficiency in N-acetylgalactosamine-4-sulfatase activity, resulting in lysosomal accumulation of partially degraded glycosaminoglycans (GAGs). Compressive myelopathy in early-onset MPS-VI patients has been partly attributed to thickening of the dura mater following engorgement with GAG. In this study, we therefore tested whether the dural abnormalities could be prevented in a feline model of the disorder. RESULTS: All intrathecal injections (IT-INJs) were well tolerated. MPS-VI cats treated with IT-INJ of recombinant human N-acetylgalactosamine-4-sulfatase (rhASB) exhibited reduced vacuolation in the dural fibroblasts, diminished levels of sulfated-N-acetylhexosamine (HNAc(+S)) in the cerebrospinal fluid (CSF) and no hind-limb paresis. Serum anti-rhASB antibodies remained low in MPS-VI cats treated with intravenous enzyme replacement therapy (IV-ERT) and increased slightly in normal cats treated with IT-INJ of rhASB alone. Anti-rhASB antibodies in CSF remained undetectable. DISCUSSION: These data indicate that repeated IT-INJ of rhASB can safely prevent GAG storage in MPS-VI dura. METHODS: Cats were assigned to three groups: (i) receiving weekly IV-ERT of rhASB from birth plus six monthly IT-INJs of rhASB from age 2 months; (ii) receiving six monthly IT-INJs of vehicle; or (iii) untreated. Additional normal cats received five fortnightly IT-INJs of rhASB or vehicle alone.; Dyane Auclair...

Strategic Approach to Smoking Bans: Delaware Gaming Industry

O'Neill, John W.; Xiao, Qu
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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A study of Delaware’s statewide smoking ban suggests that it may have had a significant negative economic impact on the state’s gaming industry. However, such impact may vary in different segments of the hospitality industry, and therefore, must be examined strategically and on a case-by-case basis. The specific market environment, including both demand and competition of each state or each municipality, should be carefully analyzed by both governmental decision makers and by hospitality operators who influence these decision makers.

Speeches of Hon. Schuyler Colfax, and General J. O'Neill, (who whipped the Queen's Own in Canada.) delivered at the great Fenian pic nic, Chicago, Aug. 15.1866.

Colfax, Schuyler, 1823-1885.; O'Neill, John 1834-1878.
Fonte: [Chicago] : s.n., Publicador: [Chicago] : s.n.,
Tipo: Artigo de Revista Científica
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Photostimulated oxygen and water vapor reactions on semiconducting titanium dioxide surfaces

O'Neill, Thomas John
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 210 leaves; 11591411 bytes; 11591167 bytes; application/pdf; application/pdf
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by Thomas John O'Neill, Jr.; Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1984.; MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE.; Vita.; Includes bibliographical references.

Fall Incidence and Outcomes of Falls in a Prospective Study of Adults With Rheumatoid Arthritis

Stanmore, Emma K; Oldham, Jackie; Skelton, Dawn A; O'Neill, Terence; Pilling, Mark; Campbell, A John; Todd, Chris
Fonte: John Wiley & Sons, Inc. Publicador: John Wiley & Sons, Inc.
Tipo: Artigo de Revista Científica
Português
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Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages

Donnelly, Sheila; Stack, Colin M.; O'Neill, Sandra M.; Sayed, Ahmed A.; Williams, David L.; Dalton, John P.
Fonte: The Federation of American Societies for Experimental Biology Publicador: The Federation of American Societies for Experimental Biology
Tipo: Artigo de Revista Científica
Publicado em /11/2008 Português
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During helminth infections, alternatively activated macrophages (AAMacs) are key to promoting Th2 responses and suppressing Th1-driven inflammatory pathology. Th2 cytokines IL-4 and/or IL-13 are believed to be important in the induction and activation of AAMacs. Using murine models for the helminth infections caused by Fasciola hepatica (Fh) and Schistosoma mansoni (Sm), we show that a secreted antioxidant, peroxiredoxin (Prx), induces alternative activation of macrophages. These activated, Ym1-expressing macrophages enhanced the secretion of IL-4, IL-5, and IL-13 from naive CD4+ T cells. Administration of recombinant FhPrx and SmPrx to wild-type and IL-4−/− and IL-13−/− mice induced the production of AAMacs. In addition, Prx stimulated the expression of markers of AAMacs (particularly, Ym1) in vitro, and therefore can act independently of IL-4/IL-13 signaling. The immunomodulatory property of Prx is not due to its antioxidant activity, as an inactive recombinant variant with active site Cys residues replaced by Gly could also induce AAMacs and Th2 responses. Immunization of mice with recombinant Prx or passive transfer of anti-Prx antibodies prior to infection with Fh not only blocked the induction of AAMacs but also the development of parasite-specific Th2 responses. We propose that Prx activates macrophages as an initial step in the induction of Th2 responses by helminth parasites and is thereby a novel pathogen-associated molecular pattern.—Donnelly...

Ti site occupancy in zircon

Tailby, Nicholas; Walker, Andrew M; Berry, Andrew John; Hermann, Joerg; Evans, Katy; Mavrogenes, John; O'Neill, Hugh; Rodina, I S; Soldatov, A.V.; Rubatto, Daniela; Sutton, Stephen
Fonte: Pergamon-Elsevier Ltd Publicador: Pergamon-Elsevier Ltd
Tipo: Artigo de Revista Científica
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Ti site occupancy in zircon (ZrSiO4) is fundamental to thermobarometry because substitution mechanisms control Ti content-temperature relations. Here we describe the results of three independent methods used to demonstrate that Ti substitutes for Si and n

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Loomis, Jen; Villavicencio, Madeleine; Tosswill, Chris; Rees, Andy; Bliss, Geoffrey; Mason, Tiffany; Oveido, Sarai; Cook, Susan; Alvarez, Lino; Cole, Sam; Howard, John; McNamara, Evan; Shaw, Ilsa; Chatti, Veena; Dunne, Carolyn; Voelker, Karl; Salsberg, Al
Fonte: Rochester Institute of Technology Publicador: Rochester Institute of Technology
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Fonte: Rochester Institute of Technology Publicador: Rochester Institute of Technology
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Loomis, Jen; McLaughlin, Joe; Bennett, Elizabeth; Bliss, Geoffrey; Howard, John; McNamara, Evan; Shaw, Ilsa; Mandanas, Laura; Villavicencio, Madeleine; Percia, Michael; Shaw, Ilsa; Hart, Rachel; Voelker, Karl; Herrera, Max
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Loomis, Jen; Crawford, Alecia; Salsberg, Alex; Shaw, Ilsa; Botzenhart, Adam; McLaughlin, Joe; Dehlinger, Casey; Howard, John
Fonte: Rochester Institute of Technology Publicador: Rochester Institute of Technology
Tipo: Magazine
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Reporter; RIT Reporter; Reporter Magazine

Loomis, Jen; Botzenhart, Adam; Spiecker, Dave; Iland, Danny; Mason, Tiffany; Oviedo, Sarai; Senese, Lacey; Shaw, Ilsa; McNamara, Evan; Dehlinger, Casey; Valenti, John; Kiewiet, Liz; Dunne, Carolyn; Metzler, Ryan
Fonte: Rochester Institute of Technology Publicador: Rochester Institute of Technology
Tipo: Magazine
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Letters (p. 04); Greenbacks for a Greener World (p. 06); Big Man on Campus (p. 07); Brick Beat (p. 08); Forecast (p. 09); SG Weekly Update (p. 09); Is The Universe Infinite? (p. 11); Ritmo Latino (p. 12); Reviews (p. 13); At Your Leisure (p. 15); Samantha Vega (p. 16); GLBTQ Center (p. 20); Fall Sports Intro (p. 25); Sports Desk (p. 26); RIT Rings (p. 30); Views (p. 31); RIT Reporter, Rochester Institute of Technology. Editor-in-Chief: Jen Loomis. Managing Editor: Adam Botzenhart. Copy Editor: Veena Chatti. News Editor: Joe McLaughlin. Leisure Editor: Casey Dehlinger. Features Editor: Laura Mandanas. Sports/Views Editor: Geoff Shearer. Writers: Adam Botzenhart, Carolyn Dunne, Danny Iland, Liz Kiewiet, Tiffany Mason, Evan McNamara, Ryan Metzler, Sarai Oviedo, Lacey Senese, Ilsa Shaw, Dave Spiecker, John Valenti. Art Director: Josh Gomby. Staff Designers: Mandy Raymond, Jason Sfetko, Contributuing Illustrators: Bryan Williams. Cartoonist: Alex Salsberg. Photo Editor: Dave Londres. Staff Photographers: Megan Rossman, Tom Schirmacher, Ross Thompson. Production Manager: John Carew. Printing: Printing Applications Lab. Publicity Manager: Kayla Himelein. Ad Manager: Geo Kartheiser. Business Manager: Lilena Harris. Customer Service Representative: Kyle O'Neill. Online Editor: Dan Orth. Advisor: Rudy Pugliese.

Proposal on a Kernal-based Evolutionary Modelling and Forecasting System Using Semiparametric Methods Applied to World Oil, Coal and Metal Markets

Terrell, Richard; Brailsford, Timothy John; O'Neill, Terence; Penm, Jack HW
Fonte: Evergreen Publishing Publicador: Evergreen Publishing
Tipo: Parte de Livro
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