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THE TICS AND ALLIED CONDITIONS*: OPENING PAPERS.

Wilson, S. A. Kinnier
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /10/1927 Português
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An Evaluation of Some Commercial Test Papers and Tablets for the Determination of Glucose in Urine

Logan, J. E.; Haight, D. E.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 12/09/1964 Português
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The commercial test papers, Tes-Tape, Clinistix, Uristix and Combistix, and the tablet preparation, Clinitest, were evaluated as indicators of glucose in urine by means of a quantitative automated glucose oxidase procedure for glucose determination. The semiquantitative Tes-Tape yielded very low values on urine specimens when compared with the quantitative method. More reliable results could be obtained with this product if the urine specimens were first treated with a mixed bed resin to remove inhibitors of the glucose oxidase peroxidase system. The qualitative test papers, Clinistix, Uristix and Combistix, yielded responses in closer agreement with the automated data, the best performance being obtained with Clinistix. The semiquantitative Clinitest tablets generally yielded more accurate results on a direct urine test than did Tes-Tape, although the Clinitest tablet is designed to measure total reducing substances rather than glucose alone.

A method of assessment during vocational training: report of a pilot study

Stanley, I.M.; Belton, A.; Freeman, P.; King, R.L.; Reed, A.; Silver, T.; Walker, J.H.; Webster, J.; Wright, H.J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1985 Português
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Problems arising from the present rate of failure of vocational trainees in the MRCGP examination are outlined; and the role of formative assessment during training in reducing this rate is considered. A study is described in which trainees in a number of centres were assessed by a method designed to measure specified cognitive abilities and areas of knowledge. The method, based on written papers, provides each candidate with a profile of performance and generates comparative standards. Reliability of marking, the distribution of candidate-scores within and between areas of assessment and techniques for monitoring the effectiveness of questions are reported. Use of the method by College as an educational service to trainees is considered, along with its potential as a Part I MRCGP examination.

Evolution of elective neck dissection in N0 laryngeal cancer

Gallo, O; Deganello, A; Scala, J; De Campora, E
Fonte: Pacini Editore SpA Publicador: Pacini Editore SpA
Tipo: Artigo de Revista Científica
Publicado em /12/2006 Português
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Management of cervical lymph node metastasis is one of the most challenging problems facing clinicians dealing with head and neck cancer. A retrospective evaluation has been made of results in N0 laryngeal cancer patients treated from 1978 to date by comparing historical data reported in related papers previously published by our institution. The medical records of 2207 consecutive patients with cN0 SCC of the larynx were used as the source of data in the present study. Together with primary treatment, 759 (34.4%) received at least unilateral elective neck dissection, while the remaining 1448 (65.6%) were admitted to a wait-and-see protocol. Overall, in the electively dissected patients (ED): 128 (16.9%) cases were submitted to classical radical neck dissection, while 403 (53.1%) cases were submitted to functional neck dissection (FND) and 228 (30.0%) cases to jugular node dissection (JND, removing Level II, III and IV). In 125 of the ED group, a neck procedure on the contralateral N0 neck was associated, of which 15 were RNDs, 35 FNDs and 75 JNDs, respectively.

Preface to Special Topic: Papers from the 2006 Annual Meeting of the American Electrophoresis Society, San Francisco, CA

Minerick, Adrienne R.; Ugaz, Victor M.
Fonte: American Institute of Physics Publicador: American Institute of Physics
Tipo: Artigo de Revista Científica
Publicado em 10/05/2007 Português
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This Special Topic section of Biomicrofluidics is dedicated to original papers from the 2006 Annual Meeting of the American Electrophoresis Society (AES: http:∕/www.aesociety.org). This five-day meeting held in San Francisco, California, included five sessions on BioMEMS and Microfluidics and four sessions on Advances in Electrokinetics and Electrophoresis. AES and its corresponding symposia provide the most focused and well-organized meeting forum for diverse biological and engineering researchers working on electrokinetics. The work featured in this Special Topic section is no exception; it ranges from nanochannel electrophoresis to bioparticle sorting.

Preface to Special Topic: Papers from the 2009 Conference on Advances in Microfluidics and Nanofluidics, The Hong Kong University of Science & Technology, Hong Kong, 2009

Yeo, Leslie Y.
Fonte: American Institute of Physics Publicador: American Institute of Physics
Tipo: Artigo de Revista Científica
Publicado em 26/06/2009 Português
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The inaugural conference on Advances in Microfluidics and Nanofluidics was held at the Hong Kong University of Science and Technology on 5–7 January 2009 and brought together leading researchers from across a wide variety of disciplines from North America, Europe, Asia, and Oceania. This Special Topic section forms the second of the two issues dedicated to original contributions covering both fundamental physicochemical aspects of microfluidics and nanofluidics as well as their applications to the miniaturization of chemical and biological systems that were presented at the conference.

Preface to Special Topic: Papers from the 82nd American Chemical Society Colloid and Surface Science Symposium, Raleigh, North Carolina, 2008

Petsev, Dimiter N.; Doyle, Patrick S.
Fonte: American Institute of Physics Publicador: American Institute of Physics
Tipo: Artigo de Revista Científica
Publicado em 30/03/2009 Português
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This Special Topic section of Biomicrofluidics contains original contributions that were presented at the 82nd Colloid and Surface Science Symposium, which took place on 15–18 June 2008 at North Carolina State University. The Symposium covered a wide range of topics that are relevant to the fundamentals of fluidics and their application to biological systems.

Ratio adjustment and calibration scheme for gene-wise normalization to enhance microarray inter-study prediction

Cheng, Chunrong; Shen, Kui; Song, Chi; Luo, Jianhua; Tseng, George C.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Português
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Motivation: Reproducibility analyses of biologically relevant microarray studies have mostly focused on overlap of detected biomarkers or correlation of differential expression evidences across studies. For clinical utility, direct inter-study prediction (i.e. to establish a prediction model in one study and apply to another) for disease diagnosis or prognosis prediction is more important. Normalization plays a key role for such a task. Traditionally, sample-wise normalization has been a standard for inter-array and inter-study normalization. For gene-wise normalization, it has been implemented for intra-study or inter-study predictions in a few papers while its rationale, strategy and effect remain unexplored.

Quantifying the Association between Campylobacter Infection and Guillain-Barré Syndrome: A Systematic Review

Poropatich, Kate O.; Walker, Christa L. Fischer; Black, Robert E.
Fonte: International Centre for Diarrhoeal Disease Research, Bangladesh Publicador: International Centre for Diarrhoeal Disease Research, Bangladesh
Tipo: Artigo de Revista Científica
Publicado em /12/2010 Português
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Guillain-Barré Syndrome (GBS) is a neurologic disease that causes ascending paralysis and is triggered by a preceding bacterial or viral infection. Several studies have shown that patients with GBS have a recent history of infection due to Campylobacter jejuni. A literature review of published studies that reported rates of Campylobacter infection before or in conjunction with GBS was done. These reported data were used for calculating the proportion of GBS cases who tested positive for Campylobacter compared to the control population and the incidence of GBS among patients infected with Campylobacter. Results of the analysis suggest that 31% of 2,502 GBS cases included in these papers are attributable to Campylobacter infection.

Selected papers from the 13th Annual Bio-Ontologies Special Interest Group Meeting

Soldatova, Larisa N; Sansone, Susanna-Assunta; Stephens, Susie M; Shah, Nigam H
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 17/05/2011 Português
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Over the years, the Bio-Ontologies SIG at ISMB has provided a forum for discussion of the latest and most innovative research in the application of ontologies and more generally the organisation, presentation and dissemination of knowledge in biomedicine and the life sciences. The ten papers selected for this supplement are extended versions of the original papers presented at the 2010 SIG. The papers span a wide range of topics including practical solutions for data and knowledge integration for translational medicine, hypothesis based querying , understanding kidney and urinary pathways, mining the pharmacogenomics literature; theoretical research into the orthogonality of biomedical ontologies, the representation of diseases, the representation of research hypotheses, the combination of ontologies and natural language processing for an annotation framework, the generation of textual definitions, and the discovery of gene interaction networks.

Directly e-mailing authors of newly published papers encourages community curation

Bunt, Stephanie M.; Grumbling, Gary B.; Field, Helen I.; Marygold, Steven J.; Brown, Nicholas H.; Millburn, Gillian H.;
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em 02/05/2012 Português
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Much of the data within Model Organism Databases (MODs) comes from manual curation of the primary research literature. Given limited funding and an increasing density of published material, a significant challenge facing all MODs is how to efficiently and effectively prioritize the most relevant research papers for detailed curation. Here, we report recent improvements to the triaging process used by FlyBase. We describe an automated method to directly e-mail corresponding authors of new papers, requesting that they list the genes studied and indicate (‘flag’) the types of data described in the paper using an online tool. Based on the author-assigned flags, papers are then prioritized for detailed curation and channelled to appropriate curator teams for full data extraction. The overall response rate has been 44% and the flagging of data types by authors is sufficiently accurate for effective prioritization of papers. In summary, we have established a sustainable community curation program, with the result that FlyBase curators now spend less time triaging and can devote more effort to the specialized task of detailed data extraction.

Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study

Mithoefer, Michael C; Wagner, Mark T; Mithoefer, Ann T; Jerome, Lisa; Martin, Scott F; Yazar-Klosinski, Berra; Michel, Yvonne; Brewerton, Timothy D; Doblin, Rick
Fonte: SAGE Publications Publicador: SAGE Publications
Tipo: Artigo de Revista Científica
Publicado em /01/2013 Português
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We report follow-up data evaluating the long-term outcomes for the first completed trial of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for chronic, treatment-resistant post-traumatic stress disorder (PTSD) (Mithoefer et al., 2011). All of the 19 subjects who received MDMA-assisted treatment in the original trial participated in the long-term follow-up (LTFU), with 16 out of 19 completing all of the long-term outcome measures, which were administered from 17 to 74 months after the original study’s final MDMA session (mean = 45.4; SD = 17.3). Our primary outcome measure used was the Clinician-Administered PTSD Scale (CAPS). Secondary outcome measures were the Impact of Events Scale-Revised (IES-R) and the Neuroticism Extroversion Oppenness Personality Inventory-Revised (NEO PI-R) Personality Inventory. We also collected a long-term follow-up questionnaire. Results for the 16 CAPS completers showed there were no statistical differences between mean CAPS score at LTFU (mean = 23.7; SD = 22.8) (tmatched = 0.1; df = 15, p = 0.91) and the mean CAPS score previously obtained at Study Exit (mean = 24.6, SD = 18.6). On average, subjects maintained statistically and clinically-significant gains in symptom relief, although two of these subjects did relapse. It was promising that we found the majority of these subjects with previously severe PTSD who were unresponsive to existing treatments had symptomatic relief provided by MDMA-assisted psychotherapy that persisted over time...

The Critical Appraisal of the Papers Published in the "Iranian Journal of Psychiatry and Behavioral Sciences", 2007-2010

Kosaryan, Mehrnoosh; Rabiei, Khadijeh
Fonte: Mazandaran University of Medical Sciences Publicador: Mazandaran University of Medical Sciences
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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Objective: This study has been done in order to evaluate the papers published in the "Iranian Journal of Psychiatry and Behavioral Sciences" from 2007 to 2010.

Investigating Financial Incentives for Maternal Health: An Introduction

Stanton, Mary Ellen; Higgs, Elizabeth S.; Koblinsky, Marge
Fonte: International Centre for Diarrhoeal Disease Research, Bangladesh Publicador: International Centre for Diarrhoeal Disease Research, Bangladesh
Tipo: Artigo de Revista Científica
Publicado em /12/2013 Português
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Projection of current trends in maternal and neonatal mortality reduction shows that many countries will fall short of the UN Millennium Development Goal 4 and 5. Underutilization of maternal health services contributes to this poor progress toward reducing maternal and neonatal morbidity and mortality. Moreover, the quality of services continues to lag in many countries, with a negative effect on the health of women and their babies, including deterring women from seeking care. To enhance the use and provision of quality maternal care, countries and donors are increasingly using financial incentives. This paper introduces the JHPN Supplement, in which each paper reviews the evidence of the effectiveness of a specific financial incentive instrument with the aim of improving the use and quality of maternal healthcare and impact. The US Agency for International Development and the US National Institutes of Health convened a US Government Evidence Summit on Enhancing Provision and Use of Maternal Health Services through Financial Incentives on 24-25 April 2012 in Washington, DC. The Summit brought together leading global experts in finance, maternal health, and health systems from governments, academia, development organizations, and foundations to assess the evidence on whether financial incentives significantly and substantially increase provision...

Moses E. Levy Correspondence. 1842-1852; David Levy Yulee Papers

Various
Fonte: Universidade da Flórida Publicador: Universidade da Flórida
Tipo: mixed material
Publicado em /1852/1842 Português
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(Biographical) Born David Levy on June 2, 1810, he spent the first few years of his life as a British subject on St. Thomas in the West Indies. His father, Moses Elias Levy, came to Spanish Florida after the War of 1812 and became a pioneer in its settlement. David was educated primarily in Virginia, and at age seventeen he moved to live on his father's plantation outside Micanopy, Florida. While there he made numerous trips to St. Augustine and cultivated the acquaintance of many Spanish and East Florida families, including some officials of the federal government. Through these contacts he met and studied law with Robert Raymond Reid, who was later governor of the state and a federal judge. After being admitted to the bar in 1832, he was successful at practicing law in St. Augustine. He began his public career by becoming a delegate to the State constitutional convention in 1838 and clerk to the Territorial Legislature in 1841.; (Biographical) That same year Levy was elected democratic territorial delegate to the national House of Representatives and served in this capacity for four years. While in office he upheld the causes of the southern states, including slavery, and he fought for Florida's admittance to the Union. In 1845 Yulee was elected as Florida's first U.S. Senator...

Essential Experimental Methods for Identifying Bonghan Systems as a Basis for Korean Medicine: Focusing on Visual Materials from Original Papers and Modern Outcomes

Kim, Hoon-Gi; Lee, Byung-Cheon; Lee, Ki-Bog
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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In the 1960s, through studies on Korean Medicine, Bonghan Kim proposed the Bonghan systems (BS) as the anatomical reality of the acupuncture meridians based on various experimental data. Since 2002, several groups, mainly led by a team at Seoul National University, who renamed the BS as the primo vascular system (PVS), have published around 70 papers showing biological structures corresponding to the BS. However, it is still difficult for other researchers to find them, especially under the skin, which Bonghan Kim first reported as acupuncture points, due to similar-looking biological tissues, for example, the lymphatic vessels, and such artifacts as blood clots or fascia debris. To solve these drawbacks, we examined the main methods for identifying the BS by comparing the original papers with the modern outcomes in terms of the common physical/chemical characteristics of the BS. In addition, effective methods of staining and microscopic observations discovered by modern teams are synthetically explained using visual materials such as diagrams and photos. Through the essentially organized methods in this review paper, we suggest that one can find the BS under the skin as putative acupuncture points by tracing the intraexternal BS, from which a new Korean Medicine will be born.

Analysis of the structure of original research papers: an aid to writing original papers for publication.

Skelton, J
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /10/1994 Português
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BACKGROUND. An increasing number of people involved in medicine are under pressure to publish research, but there is little understanding of how to describe structured writing. AIM. This paper aims to describe the structure of original research papers published in the British Journal of General Practice with a view to providing insight into the nature of such analyses, and particularly to help researchers and trainers to write and teach writing more successfully. METHOD. A sample of 50 original papers published in the Journal between January 1989 and March 1993 were examined. The papers were subjected to a form of 'move structure analysis', a technique used in applied linguistics; move structure analysis assigns a tentative function to a piece of text, and identifies words/phrases associated with it. To be recognized, moves thus identified had to occur in the same section of the paper in 65% of the corpus, and/or appear in the same order relative to other moves in 50%. RESULTS. Fifteen moves were identified, four in the introduction, three in the method, and four each in the results and discussion. These moves functioned, for example in the discussion, to state limitations and defend successes; describe achievements; contextualize procedures and findings; and offer recommendations. Frequency scores ranged from 66% to 100%...

Evaluating contributions of natural language parsers to protein–protein interaction extraction

Miyao, Yusuke; Sagae, Kenji; Sætre, Rune; Matsuzaki, Takuya; Tsujii, Jun'ichi
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Português
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Motivation: While text mining technologies for biomedical research have gained popularity as a way to take advantage of the explosive growth of information in text form in biomedical papers, selecting appropriate natural language processing (NLP) tools is still difficult for researchers who are not familiar with recent advances in NLP. This article provides a comparative evaluation of several state-of-the-art natural language parsers, focusing on the task of extracting protein–protein interaction (PPI) from biomedical papers. We measure how each parser, and its output representation, contributes to accuracy improvement when the parser is used as a component in a PPI system.

Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings

SCHUETZ, P.; KOLLER, M.; CHRIST-CRAIN, M.; STEYERBERG, E.; STOLZ, D.; MÜLLER, C.; BUCHER, H. C.; BINGISSER, R.; TAMM, M.; MÜLLER, B.
Fonte: Cambridge University Press Publicador: Cambridge University Press
Tipo: Artigo de Revista Científica
Português
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In patients with community-acquired pneumonia (CAP) prediction rules based on individual predicted mortalities are frequently used to support decision-making for in-patient vs. outpatient management. We studied the accuracy and the need for recalibration of three risk prediction scores in a tertiary-care University hospital emergency-department setting in Switzerland. We pooled data from patients with CAP enrolled in two randomized controlled trials. We compared expected mortality from the original pneumonia severity index (PSI), CURB65 and CRB65 scores against observed mortality (calibration) and recalibrated the scores by fitting the intercept α and the calibration slope β from our calibration model. Each of the original models underestimated the observed 30-day mortality of 11%, in 371 patients admitted to the emergency department with CAP (8·4%, 5·5% and 5·0% for the PSI, CURB65 and CRB65 scores, respectively). In particular, we observed a relevant mortality within the low risk classes of the original models (2·6%, 5·3%, and 3·7% for PSI classes I–III, CURB65 classes 0–1, and CRB65 class 0, respectively). Recalibration of the original risk models corrected the miscalibration. After recalibration, however, only PSI class I was sensitive enough to identify patients with a low risk (i.e. <1%) for mortality suitable for outpatient management. In our tertiary-care setting with mostly referred in-patients...

Fifty Years of CPGs: Two Neuroethological Papers that Shaped the Course of Neuroscience

Mulloney, Brian; Smarandache, Carmen
Fonte: Frontiers Research Foundation Publicador: Frontiers Research Foundation
Tipo: Artigo de Revista Científica
Publicado em 19/07/2010 Português
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Half a century ago, two independent papers that described unexpected results of experiments on locomotion in insects and crayfish appeared almost simultaneously. Together these papers demonstrated that an animal's central nervous system (CNS) was organized to produce behaviorally important motor output without the need for constant sensory feedback. These results contradicted the established line of thought that was based on interpretations of reflexes and ablation experiments, and established that in these animals the CNS contained neural circuits that could produce complex, periodic, multisegmental patterns of activity. These papers stimulated a flowering of research on central pattern-generating mechanisms that displaced reflex-based thinking everywhere except in medical physiology texts. Here we review these papers and their influence on thinking in the 1960s, 1970s, and today. We follow the development of ideas about central organization and control of expression of motor patterns, the roles of sensory input to central pattern-generating circuits, and integration of continuous sensory signals into a periodic motor system. We also review recent work on limb coordination that provides detailed cellular explanations of observations and speculations contained in those original papers.