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## PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit

Fonte: PubMed
Publicador: PubMed

Tipo: Artigo de Revista Científica

Publicado em 26/11/2008
Português

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The daily sleep cycle in humans and other mammals is driven by a complex circuit within which GABAergic sleep-promoting neurons oppose arousal systems. The latter includes the circadian system, aminergic/cholinergic systems as well as neurons secreting the peptide orexin/hypocretin, which contribute to sharp behavioral transitions (Lu and Greco, 2006). Drosophila sleep has recently been shown also to be controlled by GABAergic inputs, which act on unknown cells expressing the Rdl GABAA receptor (Agosto et al., 2008). We identify here the relevant Rdl-containing cells as a subset of the well-studied Drosophila circadian clock neurons, the PDF-expressing small and large ventral lateral neurons (LNvs). LNv activity regulates the total amount of sleep as well as the rate of sleep onset, and both large and small LNvs are part of the sleep circuit. Flies mutant for either the pdf gene or its receptor are hypersomnolent, and PDF acts on the LNvs themselves to control sleep. These features of the Drosophila sleep circuit, GABAergic control of sleep onset and maintenance as well as peptidergic control of arousal, support the idea that features of sleep circuit architecture as well as the mechanisms governing the behavioral transitions between sleep and wake are conserved between mammals and insects.

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## PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans

Fonte: PubMed
Publicador: PubMed

Tipo: Artigo de Revista Científica

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Appetitive behaviors require complex decision-making, involving the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food versus reproductive appetite. Here we show that the Pigment Dispersing Factor Receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive promoting male exploration upon mate-deprivation. PDFR-1 and its ligand PDF-1 stimulate mate searching in the male but not in the hermaphrodite. pdf-1 is required in the gender-shared interneuron AIM and the receptor acts in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1/pdfr-1 pathway functions in non sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling plays an ancient role in regulating motivational internal states.

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## A novel background field removal method for MRI using projection onto dipole fields (PDF)

Fonte: PubMed
Publicador: PubMed

Tipo: Artigo de Revista Científica

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For optimal image quality in susceptibility-weighted imaging and accurate quantification of susceptibility, it is necessary to isolate the local field generated by local magnetic sources (such as iron) from the background field that arises from imperfect shimming and variations in magnetic susceptibility of surrounding tissues (including air). Previous background removal techniques have limited effectiveness depending on the accuracy of model assumptions or information input. In this article, we report an observation that the magnetic field for a dipole outside a given region of interest (ROI) is approximately orthogonal to the magnetic field of a dipole inside the ROI. Accordingly, we propose a nonparametric background field removal technique based on projection onto dipole fields (PDF). In this PDF technique, the background field inside an ROI is decomposed into a field originating from dipoles outside the ROI using the projection theorem in Hilbert space. This novel PDF background removal technique was validated on a numerical simulation and a phantom experiment and was applied in human brain imaging, demonstrating substantial improvement in background field removal compared with the commonly used high-pass filtering method.

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## Embedding and Publishing Interactive, 3-Dimensional, Scientific Figures in Portable Document Format (PDF) Files

Fonte: Public Library of Science
Publicador: Public Library of Science

Tipo: Artigo de Revista Científica

Publicado em 25/09/2013
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With the latest release of the S2PLOT graphics library, embedding interactive, 3-dimensional (3-d) scientific figures in Adobe Portable Document Format (PDF) files is simple, and can be accomplished without commercial software. In this paper, we motivate the need for embedding 3-d figures in scholarly articles. We explain how 3-d figures can be created using the S2PLOT graphics library, exported to Product Representation Compact (PRC) format, and included as fully interactive, 3-d figures in PDF files using the movie15 LaTeX package. We present new examples of 3-d PDF figures, explain how they have been made, validate them, and comment on their advantages over traditional, static 2-dimensional (2-d) figures. With the judicious use of 3-d rather than 2-d figures, scientists can now publish, share and archive more useful, flexible and faithful representations of their study outcomes.

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## Simplified Generation of Biomedical 3D Surface Model Data for Embedding into 3D Portable Document Format (PDF) Files for Publication and Education

Fonte: Public Library of Science
Publicador: Public Library of Science

Tipo: Artigo de Revista Científica

Publicado em 15/11/2013
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The usefulness of the 3D Portable Document Format (PDF) for clinical, educational, and research purposes has recently been shown. However, the lack of a simple tool for converting biomedical data into the model data in the necessary Universal 3D (U3D) file format is a drawback for the broad acceptance of this new technology. A new module for the image processing and rapid prototyping framework MeVisLab does not only provide a platform-independent possibility to create surface meshes out of biomedical/DICOM and other data and to export them into U3D – it also lets the user add meta data to these meshes to predefine colors and names that can be processed by a PDF authoring software while generating 3D PDF files. Furthermore, the source code of the respective module is available and well documented so that it can easily be modified for own purposes.

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## Sparse PDF Volumes for Consistent Multi-Resolution Volume Rendering

Fonte: PubMed
Publicador: PubMed

Tipo: Artigo de Revista Científica

Publicado em 31/12/2014
Português

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This paper presents a new multi-resolution volume representation called sparse pdf volumes, which enables consistent multi-resolution volume rendering based on probability density functions (pdfs) of voxel neighborhoods. These pdfs are defined in the 4D domain jointly comprising the 3D volume and its 1D intensity range. Crucially, the computation of sparse pdf volumes exploits data coherence in 4D, resulting in a sparse representation with surprisingly low storage requirements. At run time, we dynamically apply transfer functions to the pdfs using simple and fast convolutions. Whereas standard low-pass filtering and down-sampling incur visible differences between resolution levels, the use of pdfs facilitates consistent results independent of the resolution level used. We describe the efficient out-of-core computation of large-scale sparse pdf volumes, using a novel iterative simplification procedure of a mixture of 4D Gaussians. Finally, our data structure is optimized to facilitate interactive multi-resolution volume rendering on GPUs.

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## EMD-Based Filtering Using Similarity Measure Between Probability Density Functions of IMFs

Fonte: IEEE
Publicador: IEEE

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#Consecutive mean squared error (CMSE)#Empirical mode decomposition (EMD)#Intrinsic mode function (IMF)#Probability density function (pdf)#Signal filtering#Similarity measure#Informatique: Traitement du signal et de l'image

This paper introduces a new signal-filtering which combines the empirical mode decomposition (EMD) and a similarity measure. A noisy signal is adaptively broken down into oscillatory components called intrinsic mode functions (IMFs) by EMD followed by an estimation of the probability density function (pdf) of each extracted mode. The key idea of this paper is to make use of partial reconstruction, the relevant modes being selected on the basis of a striking similarity between the pdf of the input signal and that of each mode. Different similarity measures are investigated and compared. The obtained results, on simulated and real signals, show the effectiveness of the pdf-based filtering strategy for removing both white Gaussian and colored noises and demonstrate its superior performance over partial reconstruction approaches reported in the literature.

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## Cosmological Implications of the PSCz PDF and its Moments

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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We compare the {\em pdf} and its low-order moments (variance and skewness) of
the smoothed PSCz galaxy density field and of the corresponding simulated PSCz
look-alikes, generated from N-body simulations of 6 different DM models; four
structure normalized with $\Gamma=0.25$ and $\sigma_{8}=0.55
\Omega_{\circ}^{-0.6}$, one COBE normalized and the old SCDM. The galaxy
distributions are smoothed with a Gaussian window at three different smoothing
scales $R_{sm}=5$, 10 and $15 \hm$. We find that the simulation PSCz look-alike
{\em pdf}'s are sensitive only on the normalization of the power spectrum,
probably due to shape similarity of the simulated galaxy power spectrum on the
relevant scales. We find that the only models that are consistent, at a high
significance level, with the observed PSCz {\em pdf} are models with a
relatively low power spectrum normalization $(\sigma_{8}=0.83)$.
From the phenomenologically derived $\sigma_{8}-moments$ relation, fitted
from the simulation data, we find that the PSCz moments suggest $\sigma_{8}
\simeq 0.7$.; Comment: final version, MNRAS Vol.327, L32

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## Comparison and combination of ZEUS and H1 PDF analyses

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Publicado em 30/08/2005
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The H1 and ZEUS published PDF analyses are compared, including a discussion
of the different treatments of correlated systematic uncertainties. Differences
in the data sets and the analyses are investigated by putting the H1 data set
through both PDF analyses and by putting the ZEUS and H1 data sets through the
same (ZEUS) analysis, separately. Finally the HERA averaged data set is put
through the ZEUS PDF analysis and the result is compared to that obtained when
putting the ZEUS and H1 data sets through this analysis together, using both
the
Offset and the Hessian methods of treating correlated systematic
uncertainties.; Comment: To appear in Proceedings of the HERA-LHC workshop 2005

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## PDF Steganography based on Chinese Remainder Theorem

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Publicado em 03/06/2015
Português

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We propose different approaches of PDF files based steganography, essentially
based on the Chinese Remainder Theorem. Here, after a cover PDF document has
been released from unnecessary A0, a secret message is hidden in it using one
of the proposed approaches, making it invisible to common PDF readers, and the
file is then transmitted through a non-secure communication channel. Where each
of our methods, ensure the condition that the number of inserted A0 is less
than the number of characters of the secret message s.; Comment: 29pages, 5 figures

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## Predicting PDF tails in systems with logarithmic non-linearity

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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The probability density function (PDF) of flux $R$ is computed in systems
with logarithmic non-linearity using a model non-linear dynamical equation. The
PDF tails of the first moment flux are analytically predicted to be power law.
These PDF tails are shown to be broader than a Gaussian distribution and are a
manifestation of intermittency caused by short lived coherent structures
(instantons).; Comment: 18 pages, 1 figure

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## Predicting PDF tails of flux in plasma sheath region

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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This letter provides the first prediction of the probability density function
(PDF) of flux $R$ in plasma sheath sheath region in magnetic fusion devices
which is characterized by dynamical equations with exponential non-linearities.
By using a non-perturbative statistical theory (instantons), the PDF tails of
first moment are shown to be modified Gumbel distribution which represents a
frequency distribution of the extreme values of the ensemble. The non-Gaussian
PDF tails that are enhanced over Gaussian predictions are the result of
intermittency caused by short lived coherent structures (instantons).; Comment: 13 pages, 1 figure

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## Analysis of non-Gaussian CMB maps based on the N-pdf. Application to WMAP data

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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We present a new method based on the N-point probability distribution (pdf)
to study non-Gaussianity in cosmic microwave background (CMB) maps. Likelihood
and Bayesian estimation are applied to a local non-linear perturbed model up to
third order, characterized by a linear term which is described by a Gaussian
N-pdf, and a second and third order terms which are proportional to the square
and the cube of the linear one. We also explore a set of model selection
techniques (the Akaike and the Bayesian Information Criteria, the minimum
description length, the Bayesian Evidence and the Generalized Likelihood Ratio
Test) and their application to decide whether a given data set is better
described by the proposed local non-Gaussian model, rather than by the standard
Gaussian temperature distribution. As an application, we consider the analysis
of the WMAP 5-year data at a resolution of around 2 degrees. At this angular
scale (the Sachs-Wolfe regime), the non-Gaussian description proposed in this
work defaults (under certain conditions) to an approximative local form of the
weak non-linear coupling inflationary model (e.g. Komatsu & Spergel 2001)
previously addressed in the literature. For this particular case, we obtain an
estimation for the non-linear coupling parameter of -94 < F_nl < 154 at 95% CL.
Equally...

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## Galaxy bias determination through the N-pdf of the galaxy number density

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Publicado em 25/06/2015
Português

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We present a full description of the N-probability density function of the
galaxy number density fluctuations. This N-pdf is given in terms, on the one
hand, of the cold dark matter correlations and, on the other hand, of the
galaxy bias parameter. The method relies on the assumption commonly adopted
that the dark matter density fluctuations follow a local non-linear
transformation of the initial energy density perturbations. The N-pdf of the
galaxy number density fluctuations allows for an optimal estimation of the bias
parameter (e.g., via maximum-likelihood estimation, or Bayesian inference if
there exists any \emph{a priori} information on the bias parameter). It also
provides the proper framework to perform model selection between two
competitive hypotheses (e.g., galaxy biasing versus a one-to-one relation
between the galaxy number density and the dark matter perturbations). The bias
estimation capabilities of the N-pdf are proved by SDSS-like simulations,
showing that our estimator is unbiased. We apply our formalism to the 7th
release of the SDSS main sample (for a volume-limited subset with absolute
magnitudes $M_r \leq -20$). We obtain a maximum-likelihood bias estimate
$\hat{b} = 1.500 \pm 0.036$, for galaxy number density fluctuations in cells of
the size of $30h^{-1}$Mpc. Different model selection criteria show that galaxy
biasing is clearly favoured.; Comment: Submitted to JCAP...

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## The 1-point PDF of the Initial Conditions of our Local Universe from the IRAS PSC redshift catalogue

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Publicado em 05/06/2000
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The algorithm ZTRACE of Monaco & Efstathiou (1999) is applied to the IRAS
PSCz catalogue to reconstruct the initial conditions of our local Universe with
a resolution down to ~5 Mpc/h. The 1-point PDF of the reconstructed initial
conditions is consistent with the assumptions that (i) IRAS galaxies trace mass
on scales of ~5 Mpc/h, and (ii) the statistics of primordial density
fluctuations is Gaussian. We use simulated PSCz catalogues, constructed from
N-body simulations with Gaussian initial conditions, to show that local
non-linear bias can cause the recovered initial PDF (assuming no bias) to be
non-Gaussian. However, for plausible bias models, the distortions of the
recovered PDF would be difficult to detect using the volume finely sampled by
the PSCz catalogue. So, for Gaussian initial conditions, a range of bias models
remain compatible with our PSCz reconstruction results.; Comment: 13 pages, figures included (needs mn.sty), in press on MNRAS

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## Construction of the one-point PDF of the local aperture mass in weak lensing maps

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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We present a general method for the reconstruction of the one-point
Probability Distribution Function of the local aperture mass in weak lensing
maps. Exact results, that neglect the lens-lens coupling and departure form the
Born approximation, are derived for both the quasilinear regime at leading
order and the strongly nonlinear regime assuming the tree hierarchical model is
valid. We describe in details the projection effects on the properties of the
PDF and the associated generating functions. In particular, we show how the
generic features which are common to both the quasilinear and nonlinear regimes
lead to two exponential tails for $P(\Map)$. We briefly investigate the
dependence of the PDF with cosmology and with the shape of the angular filter.
Our predictions are seen to agree reasonably well with the results of numerical
simulations and should be able to serve as foundations for alternative methods
to measure the cosmological parameters that take advantage of the full shape of
the PDF.; Comment: 17 pages, final version published in A&A

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## PDF of Velocity Fluctuation in Turbulence by a Statistics based on Generalized Entropy

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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An analytical formula for the probability density function (PDF) of the
velocity fluctuation in fully-developed turbulence is derived,
non-perturbatively, by assuming that its underlying statistics is the one based
on the generalized measures of entropy, the R\'{e}nyi entropy or the
Tsallis-Havrda-Charvat (THC) entropy. The parameters appeared in the PDF,
including the index $q$ which appears in the measures of the R\'{e}nyi entropy
or of the THC entropy are determined self-consistently with the help of the
observed value $\mu$ of the intermittency exponent. The derived PDF explains
quite well the experimentally observed density functions.; Comment: 10 pages, 2 figures

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## Implications of CTEQ PDF analysis for collider observables

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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In the context of a recent CTEQ6.6 global analysis, we review a new technique
for studying correlated theoretical uncertainties in hadronic observables
associated with imperfect knowledge of parton distribution functions (PDFs).
The technique is based on the computation of correlations between the predicted
values of physical observables in the Hessian matrix method. It can be used,
for example, to link the dominant PDF uncertainty in a hadronic cross section
to PDFs for individual parton flavors at well-defined $(x,\mu)$ values. As an
illustration, we apply the PDF correlation analysis to study regularities in
the PDF dependence of Z, W, and Higgs boson production cross sections at the
Tevatron and LHC.; Comment: Contribution to the Proceedings of XVI International Workshop on
Deep-Inelastic Scattering and Related Subjects (DIS 2008), London, UK, 7-11
April 2008; 4 pages

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## APFEL: A PDF Evolution Library with QED corrections

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Português

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#High Energy Physics - Phenomenology#High Energy Physics - Experiment#Nuclear Experiment#Nuclear Theory

Quantum electrodynamics and electroweak corrections are important ingredients
for many theoretical predictions at the LHC. This paper documents APFEL, a new
PDF evolution package that allows for the first time to perform DGLAP evolution
up to NNLO in QCD and to LO in QED, in the variable-flavor-number scheme and
with either pole or MSbar heavy quark masses. APFEL consistently accounts for
the QED corrections to the evolution of quark and gluon PDFs and for the
contribution from the photon PDF in the proton. The coupled QCD+QED equations
are solved in x-space by means of higher order interpolation, followed by
Runge-Kutta solution of the resulting discretized evolution equations. APFEL is
based on an innovative and flexible methodology for the sequential solution of
the QCD and QED evolution equations and their combination. In addition to PDF
evolution, APFEL provides a module that computes Deep-Inelastic Scattering
structure functions in the FONLL general-mass variable-flavor-number scheme up
to O($\alpha_s^2$). All the functionalities of APFEL can be accessed via a
Graphical User Interface, supplemented with a variety of plotting tools for
PDFs, parton luminosities and structure functions. Written in Fortran 77, APFEL
can also be used via the C/C++ and Python interfaces...

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## Top production at the LHC: the impact of PDF uncertainties and correlations

Fonte: Universidade Cornell
Publicador: Universidade Cornell

Tipo: Artigo de Revista Científica

Publicado em 27/08/2010
Português

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In this contribution we discuss the impact of PDF uncertainties on t\bar{t}
and t-channel single-top production at the LHC. We present predictions for
total cross-sections computed at NLO accuracy with different PDF sets. For
single- top production, we point out that the uncertainty arising from the
choice of the bottom quark mass is one of the dominant theoretical
uncertainties on the total cross-section. Finally, the possibility of using PDF
induced correlations between top quark and electroweak vector boson production
cross-sections to improve the accuracy of LHC measurements is investigated.; Comment: 8 pages, 5 figures. To appear in the Proceedings of the International
Workshop on Top Quark Physics (top2010), Bruges, Belgium, May 31 - June 4,
2010

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