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Regular inhaled beta agonist in asthma: effects on exacerbations and lung function.

Taylor, D R; Sears, M R; Herbison, G P; Flannery, E M; Print, C G; Lake, D C; Yates, D M; Lucas, M K; Li, Q
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /02/1993 Português
Relevância na Pesquisa
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BACKGROUND: A comparison of the effects of regular upsilon as needed inhaled beta agonist treatment on the control of asthma in the last 16 weeks of each of two 24 week treatment periods has been reported. This paper presents additional information on exacerbations of asthma and trends in lung function, airways hyperresponsiveness to methacholine, and bronchodilator responsiveness during the entire 24 week periods of regular or as needed beta agonist treatment. METHODS: Subjects undertook a year long randomised, double blind crossover study of regular upsilon as needed inhaled beta agonist treatment. Fenoterol (400 micrograms) or matching placebo was inhaled as a dry powder four times daily for 24 weeks, then subjects crossed over to the alternative regimen. Treatment with inhaled corticosteroids was used by 50 of the 64 subjects in constant doses throughout the study. Symptoms, peak expiratory flow rates, and drug use were recorded daily, spirometry was performed every four weeks, and methacholine and bronchodilator responsiveness were measured every eight weeks. RESULTS: Exacerbations of asthma symptoms occurred earlier and more often during regular treatment with fenoterol and four of five severe exacerbations requiring admission to hospital occurred during the period of regular treatment. Prebronchodilator forced expiratory volume in one second (FEV1) was on average 0.15 litres lower (95% confidence interval (95% CI) 0.11-0.19) and vital capacity (VC) 0.12 litres lower (95% CI 0.08-0.16) than during the placebo period. Morning peak flow rates were significantly lower and evening peak flow rates significantly higher...

Factors associated with regular episodes of dysuria among women in one rural general practice.

Jolleys, J V
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /06/1991 Português
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The aim of this study was to ascertain the factors associated with frequency-dysuria (urethral) syndrome in a population of women. The study included all women aged 25 years and over on 1 May 1987 who had been registered with one rural, dispensing practice over the study period, 1 May 1985 to 1 May 1989. A self-administered questionnaire was sent to the women on 1 May 1987 and a second, similar, questionnaire was sent two years later. A total of 721 women responded to the two questionnaires (response rate 97%). Regular symptoms of frequency and dysuria were reported by 8% of women in 1987 and 14% in 1989. Four percent of women reported symptoms throughout the four year study period. Symptoms were found to be least common in the 55-74 years age group. Although none of the women who were sexually inactive reported regular symptoms no association was reported between recent sexual intercourse and symptoms. Neither was an association demonstrated between type of contraception used and symptoms. However, it was found that premenopausal women reported significantly more symptoms than postmenopausal women. The number of women involved in this study was too small to allow the importance of change of sexual partner to be determined. Significantly more of the women who reported regular symptoms had been treated for urinary tract infection than of those who did not report regular symptoms. Although a history of regular frequency and dysuria points to a diagnosis of urethral syndrome...

Insurance or a regular physician: which is the most powerful predictor of health care?

Sox, C M; Swartz, K; Burstin, H R; Brennan, T A
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /03/1998 Português
Relevância na Pesquisa
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OBJECTIVES: This study compared the relative effects on access to health care of relationship with a regular physician and insurance status. METHODS: The subjects were 1952 nonretired, non-Medicare patients aged 18 to 64 years who presented with 1 of 6 chief complaints to 5 academic hospital emergency departments in Boston and Cambridge, Mass, during a 1-month study period in 1995. Access to care was evaluated by 3 measures: delay in seeking care for the current complaint, no physician visit in the previous year, and no emergency department visit in the previous year. RESULTS: After clinical and socioeconomic characteristics were controlled, lacking a regular physician was a stronger, more consistent predictor than insurance status of delay in seeking care (odds ratio [OR] = 1.6, 95% confidence interval [CI] = 1.2, 2.1), no physician visit [OR] = 4.5%, 95% CI = 3.3, 6.1), and no emergency department visit (OR = 1.8, 95% CI = 1.4, 2.4). For patients with a regular physician, access was no different between the uninsured and the privately insured. For privately insured patients, those with no regular physician had worse access than those with a regular physician. CONCLUSIONS: Among patients presenting to emergency departments, relationship with a regular physician is a stronger predictor than insurance status of access to care.

Characteristics of individuals who identify a regular source of medical care.

Lave, J R; Lave, L B; Leinhardt, S; Nagin, D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /03/1979 Português
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Having a source where medical services are regularly received is an antecedent to securing high quality medical care; it facilitates access and indicates that the individual is not alienated from the health care delivery system. In this paper we develop models to characterize individuals, both children and adults, who claim a regular source of care. The models are estimated using a logit analysis (since the dependent variable is 0-1) applied to survey data on residents of East Palo Alto, California. These data indicate that in this low-income, predominately black population the most important factor influencing whether a child will have a regular source of medical care is whether the parents have a regular source. For adults, the anticipated need for care (as measured by health status), time in community, and sex were all found to be important. The type of individual least likely to have a regular source of care is a low-income, unmarried male who is in good health and is a recent arrival to the community. The individuals most likely to need easy access to medical care and continuity of care are most likely to have a regular source of care, and vice versa.

Canadians without regular medical doctors. Who are they?

Talbot, Y.; Fuller-Thomson, E.; Tudiver, F.; Habib, Y.; McIsaac, W. J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/2001 Português
Relevância na Pesquisa
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OBJECTIVE: Because having a regular medical doctor is associated with positive outcomes, this study attempted to determine the characteristics of Canadians without regular doctors so that alternative methods of delivering care to people with those characteristics can be studied. DESIGN: Secondary data analysis of the National Population Health Survey using bivariate analyses and logistic regression. PARTICIPANTS: A total of 15,777 respondents older than 20 years. MAIN OUTCOME MEASURES: Responses to the question "Do you have a regular medical doctor?" and analysis of 11 variables covering demographics, health status, and lifestyle factors. RESULTS: One in seven respondents did not have a regular doctor. Younger respondents, men, single people, poorer respondents, respondents who perceived themselves in better health, recent immigrants, those without confidants, and smokers were more likely not to have regular doctors. Comparing provinces, participants from Quebec were least likely to have regular doctors. CONCLUSION: Primary care reform might need to consider alternative ways of providing care to certain people. Future primary care programs could be targeted to improve coverage of relatively underserviced people, particularly men, people on low incomes...

Does having regular care by a family physician improve preventive care?

McIsaac, W. J.; Fuller-Thomson, E.; Talbot, Y.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/2001 Português
Relevância na Pesquisa
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OBJECTIVE: To assess whether regular care from a family physician is associated with receiving preventive services. DESIGN: Secondary analysis of the 1994 National Population Health Survey. SETTING: Cross-sectional sample of the Canadian population. PARTICIPANTS: A total of 15,731 non-institutionalized adults. MAIN OUTCOME MEASURES: Reported visits to general practitioners and specialists in the previous year and reports of having had blood pressure measurements, mammography, and Pap smears. RESULTS: A graded relationship was observed between level of regular care by a family physician in the previous year (none, some, regular) and receiving preventive services. Those without regular doctors and those reporting only some care by a family physician were less likely to have ever had their blood pressure checked than adults receiving ongoing care from a regular family physician. Women reporting some or no care were less likely to have had mammography within 2 years or to have ever had Pap smears. CONCLUSION: Adults who receive regular care from a family physician are more likely to receive recommended preventive services.

Patients seeking care during acute illness. Why do they not see their regular physicians?

Mathews, Maria; Barnsley, Jan
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /11/2003 Português
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OBJECTIVE: To identify factors that predict whether patients prefer seeing their regular physicians and whether they do see their regular physicians during acute illness. DESIGN: Cross-sectional, population-based telephone survey. SETTING: Urban areas in southern Ontario. PARTICIPANTS: Random sample of 304 people who had regular physicians, insurance coverage, and had last seen a physician for acute illness. Of the 304, 256 (84.2%) preferred seeing their regular physicians during acute illness, and 48 (15.8%) did not. Of those who preferred seeing their regular physicians, 131 (51.2%) did see their regular physicians, 125 (48.8%) did not MAIN OUTCOME MEASURES: Preference for seeing regular physician and seeing regular physician during acute illness. RESULTS: Multiple logistic regression found that believing continuity of care was important and traveling further increased, while recent hospitalization and difficulty seeing physicians during or after office hours decreased, the likelihood of actually seeing their regular physicians. CONCLUSION: Almost half the patients who preferred seeing their regular physicians for acute illness did not actually see their regular physicians. Improving access to regular physicians might encourage patients to always try to see them.

Regular use of analgesics is a risk factor for renal cell carcinoma

Gago-Dominguez, M; Yuan, J-M; Castelao, J E; Ross, R K; Yu, M C
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Publicado em /10/1999 Português
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Phenacetin-based analgesics have been linked to the development of renal pelvis cancer and renal cell carcinoma (RCC). The relationship between non-phenacetin types of analgesics and kidney cancer is less clear, although laboratory evidence suggests that these drugs possess carcinogenic potential. A population-based case–control study involving 1204 non-Asian RCC patients aged 25–74 and an equal number of sex-, age- and race-matched neighbourhood controls was conducted in Los Angeles, California, to investigate the relationship between sustained use of analgesics and risk of RCC according to major formulation categories. Detailed information on medical and medication histories, and other lifestyle factors was collected through in-person interviews. Regular use of analgesics was a significant risk factor for RCC in both men and women (odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.4–1.9 for both sexes combined). Risks were elevated across all four major classes of analgesics (aspirin, non-steroidal anti-inflammatory agents other than aspirin, acetaminophen and phenacetin). Within each class of analgesics, there was statistically significant increasing risk with increasing level of exposure. Although there was some minor variability by major class of formulation...

The role of Broca’s area in regular past-tense morphology: An event-related potential study

Justus, Timothy; Larsen, Jary; Yang, Jennifer; de Mornay Davies, Paul; Dronkers, Nina; Swick, Diane
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
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It has been suggested that damage to anterior regions of the left hemisphere results in a dissociation in the perception and lexical activation of past-tense forms. Specifically, in a lexical-decision task in which past-tense primes immediately precede present-tense targets, such patients demonstrate significant priming for irregular verbs (spoke-speak), but, unlike control participants, fail to do so for regular verbs (looked-look). Here, this behavioral dissociation was first confirmed in a group of eleven patients with damage to the pars opercularis (BA 44) and pars triangularis (BA 45) of the left inferior frontal gyrus (i.e., Broca’s area). Two conditions containing word-onset orthographic-phonological overlap (bead-bee, barge-bar) demonstrated that the disrupted regular-verb priming was accompanied by, and covaried with, disrupted ortho-phonological priming, regardless of whether prime stimuli contained the regular inflectional rhyme pattern. Further, the dissociation between impaired regular-verb and preserved irregular-verb priming was shown to be continuous rather than categorical; priming for weak-irregular verbs (spent-spend) was intermediate in size between that of regular verbs and strong verbs. Such continuous dissociations grounded in ortho-phonological relationships between present- and past-tense forms are predicted by single-system...

BODY MASS INDEX AND REGULAR SMOKING IN YOUNG ADULT WOMEN

Duncan, Alexis E.; Lessov-Schlaggar, Christina N.; Nelson, Elliot C.; Pergadia, Michele L.; Madden, Pamela A.F.; Heath, Andrew C.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
350.4787%
Little is known about the relationship between relative body weight and transition from experimentation to regular smoking in young adult women. In the current study, data from 2494 participants in wave 4 of the Missouri Adolescent Female Twin Study (aged 18-29 years) who reported ever smoking a cigarette were analyzed using logistic regression. Body mass index (BMI) at time of interview was categorized according to CDC adult guidelines, and regular smoking was defined as having ever smoked 100 or more cigarettes and having smoked at least once a week for two months in a row. Since the OR’s for the overweight and obese groups did not differ significantly from one another in any model tested, these groups were combined. Forty-five percent of women who had ever smoked had become regular smokers. Testing of interactions between potential covariates and levels of the categorical BMI variable revealed a significant interaction between overweight/obesity and childhood sexual abuse (CSA; p<0.001) associated with regular smoking. Among women reporting CSA, the association between overweight/obesity and having become a regular smoker was negative (n=374; OR=0.48, 95% CI: 0.28-0.81). Both underweight and overweight/obesity were positively associated with transition to regular smoking among women who did not report CSA (n=2076; OR=1.57...

TARGET-SPECIFIC OUTPUT PATTERNS CAN BE PREDICTED BY THE DISTRIBUTION OF REGULAR-SPIKING AND BURSTING PYRAMIDAL NEURONS IN THE SUBICULUM

Kim, Yujin; Spruston, Nelson
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
349.68727%
Pyramidal neurons in the subiculum project to a variety of cortical and subcortical areas in the brain to convey information processed in hippocampus. Previous studies have shown that two groups of subicular pyramidal neurons – regular-spiking and bursting neurons – are distributed in an organized fashion along the proximal-distal axis, with more regular-spiking neurons close to CA1 (proximal) and more bursting neurons close to presubiculum (distal). Anatomically, neurons projecting to some targets are located more proximally along this axis, while others are located more distally. However, the relationship between the firing properties and the targets of subicular pyramidal neurons is not known. To study this relationship, we used in vivo injections of retrogradely transported fluorescent beads into each of nine different regions and conducted whole-cell current-clamp recordings from the bead-containing subicular neurons in acute brain slices. We found that subicular projections to each area were composed of a mixture of regular-spiking and bursting neurons. Neurons projecting to amygdala, lateral entorhinal cortex, nucleus accumbens, and medial/ventral orbitofrontal cortex were located primarily in the proximal subiculum and consisted mostly of regular-spiking neurons (~80%). By contrast...

Functional Neuroimaging Study in Identical Twin Pairs Discordant for Regular Cigarette Smoking

Lessov-Schlaggar, Christina N.; Lepore, Rebecca L.; Kristjansson, Sean D.; Schlaggar, Bradley L.; Barnes, Kelly Anne; Petersen, Steven E.; Madden, Pamela A. F.; Heath, Andrew C.; Barch, Deanna M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
351.11496%
Despite the tremendous public health and financial burden of cigarette smoking, relatively little is understood about brain mechanisms that subserve smoking behavior. This study investigated the effect of lifetime regular smoking on brain processing in a reward guessing task using functional magnetic resonance imaging (fMRI) and a cotwin-control study design in monozygotic (MZ) twin pairs that maximally controls for genetic and family background factors. Young adult (24–34 years) MZ female twin pairs (n=15 pairs), discordant for regular smoking defined using Centers for Disease Control (CDC) criteria as having smoked ≥100 cigarettes lifetime were recruited from an ongoing genetic epidemiological longitudinal study of substance use and psychopathology. We applied hypothesis-driven region of interest and whole brain analyses to investigate the effect of regular smoking on reward processing. Reduced response to reward and punishment in regular compared to never-regular smokers was seen in hypothesis-driven region of interest analysis of bilateral ventral striatum. Whole brain analysis identified bilateral reward-processing regions that showed activation differences in response to winning or losing money but no effect of regular smoking; and frontal/parietal regions...

Predictors of regular cigarette smoking among adolescent females: Does body image matter?

Kaufman, Annette R.; Augustson, Erik M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /08/2008 Português
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This study examined how factors associated with body image predict regular smoking in adolescent females. Data were from the National Longitudinal Study of Adolescent Health (Add Health), a study of health-related behaviors in a nationally representative sample of adolescents in grades 7 through 12. Females in Waves I and II (n=6,956) were used for this study. Using SUDAAN to adjust for the sampling frame, univariate and multivariate analyses were performed to investigate if baseline body image factors, including perceived weight, perceived physical development, trying to lose weight, and self-esteem, were predictive of regular smoking status 1 year later. In univariate analyses, perceived weight (p<.01), perceived physical development (p<.0001), trying to lose weight (p<.05), and self-esteem (p<.0001) significantly predicted regular smoking 1 year later. In the logistic regression model, perceived physical development (p<.05), and self-esteem (p<.001) significantly predicted regular smoking. The more developed a female reported being in comparison to other females her age, the more likely she was to be a regular smoker. Lower self-esteem was predictive of regular smoking. Perceived weight and trying to lose weight failed to reach statistical significance in the multivariate model. This current study highlights the importance of perceived physical development and self-esteem when predicting regular smoking in adolescent females. Efforts to promote positive self-esteem in young females may be an important strategy when creating interventions to reduce regular cigarette smoking.

Effect of Regular Exercise on the Histochemical Changes of d-Galactose-Induced Oxidative Renal Injury in High-Fat Diet-Fed Rats

Park, Sok; Kim, Chan-Sik; Lee, Jin; Suk Kim, Jung; Kim, Junghyun
Fonte: Japan Society of Histochemistry and Cytochemistry Publicador: Japan Society of Histochemistry and Cytochemistry
Tipo: Artigo de Revista Científica
Português
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448.67594%
Renal lipid accumulation exhibits slowly developing chronic kidney disease and is associated with increased oxidative stress. The impact of exercise on the obese- and oxidative stress-related renal disease is not well understood. The purpose of this study was to investigate whether a high-fat diet (HFD) would accelerate d-galactose-induced aging process in rat kidney and to examine the preventive effect of regular exercise on the obese- and oxidative stress-related renal disease. Oxidative stress was induced by an administration of d-galactose (100 mg/kg intraperitoneally injected) for 9 weeks, and d-galactose-treated rats were also fed with a high-fat diet (60% kcal as fat) for 9 weeks to induce obesity. We investigated the efficacy of regular exercise in reducing renal injury by analyzing Nε-carboxymethyllysine (CML), 8-hydroxygluanine (8-OHdG) and apoptosis. When rats were fed with a HFD for 9 weeks in d-galactose-treated rats, an increased CML accumulation, oxidative DNA damage and renal podocyte loss were observed in renal glomerular cells and tubular epithelial cells. However, the regular exercise restored all these renal changes in HFD plus d-galactose-treated rats. Our data suggested that long-term HFD may accelerate the deposition of lipoxidation adducts and oxidative renal injury in d-galactose-treated rats. The regular exercise protects against obese- and oxidative stress-related renal injury by inhibiting this lipoxidation burden.

Lesions impairing regular versus irregular past tense production☆

Meteyard, Lotte; Price, Cathy J.; Woollams, Anna M.; Aydelott, Jennifer
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em 14/10/2013 Português
Relevância na Pesquisa
350.4787%
We investigated selective impairments in the production of regular and irregular past tense by examining language performance and lesion sites in a sample of twelve stroke patients. A disadvantage in regular past tense production was observed in six patients when phonological complexity was greater for regular than irregular verbs, and in three patients when phonological complexity was closely matched across regularity. These deficits were not consistently related to grammatical difficulties or phonological errors but were consistently related to lesion site. All six patients with a regular past tense disadvantage had damage to the left ventral pars opercularis (in the inferior frontal cortex), an area associated with articulatory sequencing in prior functional imaging studies. In addition, those that maintained a disadvantage for regular verbs when phonological complexity was controlled had damage to the left ventral supramarginal gyrus (in the inferior parietal lobe), an area associated with phonological short-term memory. When these frontal and parietal regions were spared in patients who had damage to subcortical (n = 2) or posterior temporo-parietal regions (n = 3), past tense production was relatively unimpaired for both regular and irregular forms. The remaining (12th) patient was impaired in producing regular past tense but was significantly less accurate when producing irregular past tense. This patient had frontal...

Regular exercise modulates obesity factors and body composition in sturdy men

Ko, Il-Gyu; Choi, Pil-Byung
Fonte: Korean Society of Exercise Rehabilitation Publicador: Korean Society of Exercise Rehabilitation
Tipo: Artigo de Revista Científica
Publicado em 25/04/2013 Português
Relevância na Pesquisa
352.44535%
The purpose of this study was to find the change and correlation between obesity factors and body composition according to regular exercise. Thirty-six sturdy men at twenty years old in ‘K’ university students were participated in this study. The subjects were randomly divided into two groups (n= 18 in each group): control group and regular exercise group. Exercise program composed of three programs: warm-up (10 min), work-out (30–60 min), cool-down (10 min), and categorized by five days per week for eight weeks. Aerobic exercise using a treadmill at 60% of heart rate reserve was performed, and weight training was composed of nine different exercises for the large muscles. Before the performing regular exercise, there was no significant difference between control and regular exercise groups. In the present results, 8 weeks regular exercise significantly decreased leptin, weight, fat mass, % fat, waist to hip ratio (WHR), and body mass index (BMI) more than compared to before performing regular exercise, whereas significantly enhanced lean mass more than compared to before performing regular exercise. Furthermore, regular exercise group reduced leptin, weight, fat mass, % fat, WHR, and BMI compared to control group in the post test. In the correlation of obesity-related factors and body composition...

End-Completely-Regular and End-Inverse Lexicographic Products of Graphs

Hou, Hailong; Gu, Rui
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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A graph X is said to be End-completely-regular (resp., End-inverse) if its endomorphism monoid End(X) is completely regular (resp., inverse). In this paper, we will show that if X[Y] is End-completely-regular (resp., End-inverse), then both X and Y are End-completely-regular (resp., End-inverse). We give several approaches to construct new End-completely-regular graphs by means of the lexicographic products of two graphs with certain conditions. In particular, we determine the End-completely-regular and End-inverse lexicographic products of bipartite graphs.

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

Park, Sohyun; Blanck, Heidi M.; Sherry, Bettylou; Jones, Sherry Everett; Pan, Liping
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/2013 Português
Relevância na Pesquisa
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Limited research shows an inconclusive association between soda intake and asthma, potentially attributable to certain preservatives in sodas. This cross-sectional study examined the association between regular (nondiet)-soda intake and current asthma among a nationally representative sample of high school students. Analysis was based on the 2009 national Youth Risk Behavior Survey and included 15,960 students (grades 9 through 12) with data for both regular-soda intake and current asthma status. The outcome measure was current asthma (ie, told by doctor/nurse that they had asthma and still have asthma). The main exposure variable was regular-soda intake (ie, drank a can/bottle/glass of soda during the 7 days before the survey). Multivariable logistic regression was used to estimate the adjusted odds ratios for regular-soda intake with current asthma after controlling for age, sex, race/ethnicity, weight status, and current cigarette use. Overall, 10.8% of students had current asthma. In addition, 9.7% of students who did not drink regular soda had current asthma, and 14.7% of students who drank regular soda three or more times per day had current asthma. Compared with those who did not drink regular soda, odds of having current asthma were higher among students who drank regular soda two times per day (adjusted odds ratio = 1.28; 95% CI 1.02 to 1.62) and three or more times per day (adjusted odds ratio = 1.64; 95% CI 1.25 to 2.16). The association between high regular-soda intake and current asthma suggests efforts to reduce regular-soda intake among youth might have benefits beyond improving diet quality. However...

Improved Efficacy of Temporally Non-Regular Deep Brain Stimulation in Parkinson's Disease

Brocker, David T; Swan, Brandon D; Turner, Dennis A; Gross, Robert E; Tatter, Stephen B; Koop, Mandy Miller; Bronte-Stewart, Helen; Grill, Warren M
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
353.0405%
High frequency deep brain stimulation is an effective therapy for motor symptoms in Parkinson's disease. However, the relative clinical efficacy of regular versus non-regular temporal patterns of stimulation in Parkinson's disease remains unclear. To determine the temporal characteristics of non-regular temporal patterns of stimulation important for treatment of Parkinson's disease, we compared the efficacy of temporally regular stimulation with four non-regular patterns of stimulation in subjects with Parkinson's disease using an alternating finger tapping task. The patterns of stimulation were also evaluated in a biophysical model of the parkinsonian basal ganglia that exhibited prominent oscillatory activity in the beta frequency range. The temporal patterns of stimulation differentially improved motor task performance. Three of the non-regular patterns of stimulation improved performance of the finger tapping task more than temporally regular stimulation. In the computational model all patterns of deep brain stimulation suppressed beta band oscillatory activity, and the degree of suppression was strongly correlated with the clinical efficacy across stimulation patterns. The three non-regular patterns of stimulation that improved motor performance over regular stimulation also suppressed beta band oscillatory activity in the computational model more effectively than regular stimulation. These data demonstrate that the temporal pattern of stimulation is an important consideration for the clinical efficacy of deep brain stimulation in Parkinson's disease. Furthermore...

Teenage work: the experience of a regular occupation; Trabalho adolescente: a experiência de uma ocupação regular

Oliveira, Régia Cristina
Fonte: Universidade de São Paulo. Instituto de Psicologia Publicador: Universidade de São Paulo. Instituto de Psicologia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf
Publicado em 01/06/2011 Português
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The present text aims to discuss issues referring to the experience of regular and monitored work, directed to teenagers from low income backgrounds. It addresses issues which emerged from a doctorate research on the participation of teenagers from low classes in a program withheld by the Empresa de Correios e Telégrafos (Mail Services) of São Paulo, named The Assisted Teenager. In this article, important issues are highlighted, such as: the association between poverty and marginalization in the use of the term minor; the representations that level youth, adolescence and poverty categories and justifies intervention practices; the work experience at the company and the moralizing normalizations; and the notions of employability defined by the company. Furthermore, we point out the condition of a regular entry into the labor market, taking into account that not only in Brazil, but in other countries as well, precarious jobs and unemployment tend to be associated to teenagers from low income backgrounds, in national as international researches that study this thematic and social actor.; O presente artigo tem o propósito de discutir questões referentes à experiência de trabalho regular e monitorado, voltado para adolescentes de baixa renda. Trata-se da reflexão de questões encontradas na pesquisa de doutorado relativas à participação de adolescentes das camadas populares em um programa da Empresa de Correios e Telégrafos de São Paulo denominado Adolescente Assistido. Dessa participação...