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Estudo do tempo de excreção renal pela cintilografia em felinos domésticos; Urinary excretion rate assessment by scintigraphy in domestic cats

Jarretta, Georgea Bignardi; Bombonato, Pedro Primo; De Martin, Benedicto Wlademir
Fonte: São Paulo Publicador: São Paulo
Tipo: Artigo de Revista Científica
Português
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Na rotina clinica de felinos domesticos, algumas modalidades de diagnostico por imagem, como a ultrassonografia, radiografia simples e urografia excretora, ja sao amplamente utilizadas. A cintilografia e uma tecnica nao invasiva, capaz de oferecer informacoes funcionais de rins individualmente, porem e considerada uma modalidade menos usual. O objetivo deste estudo foi verificar o tempo de excrecao renal de felinos domesticos por meio da cintilografia, em animais com parametros ultrassonograficos e radiograficos dentro dos limites da normalidade. Foram utilizados 15 animais, nove machos e seis femeas, e estes foram divididos em grupos de animais nao submetidos a anestesia e anestesiados. Foi estabelecido o tempo para o radiofarmaco obter acumulo maximo em cada um dos rins e o tempo para este acumulo maximo ser reduzido a metade. Nao houve diferenca estatistica entre os valores dos animais nao-anestesiados e anestesiados, nem entre os rins esquerdo e direito, tampouco entre machos e fêmeas; In internal medicine of domestic cats, some imaging diagnosis modalities, such as ultrasonography, radiography and intravenous pylogram are spreadly used. Scintigraphy is a non-invasive technique, which provides functional information of individual kidneys; however...

The role of myocardial scintigraphy in the assessment of cardiovascular risk in patients with end-stage chronic kidney disease on the waiting list for renal transplantation

Galvao De Lima, Jose Jayme; Wolff Gowdak, Luis Henrique; de Paula, Flavio Jota; Franchini Ramires, Jose Antonio; Bortolotto, Luiz A.
Fonte: OXFORD UNIV PRESS; OXFORD Publicador: OXFORD UNIV PRESS; OXFORD
Tipo: Artigo de Revista Científica
Português
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The usefulness of stress myocardial perfusion scintigraphy for cardiovascular (CV) risk stratification in chronic kidney disease remains controversial. We tested the hypothesis that different clinical risk profiles influence the test. We assessed the prognostic value of myocardial scintigraphy in 892 consecutive renal transplant candidates classified into four risk groups: very high (aged epsilon 50 years, diabetes and CV disease), high (two factors), intermediate (one factor) and low (no factor). The incidence of CV events and death was 20 and 18, respectively (median follow-up 22 months). Altered stress testing was associated with an increased probability of cardiovascular events only in intermediate-risk (one risk factor) patients [30.3 versus 10, hazard ratio (HR) 2.37, confidence interval (CI) 1.693.33, P 0.0001]. Low-risk patients did well regardless of scan results. In patients with two or three risk factors, an altered stress test did not add to the already increased CV risk. Myocardial scintigraphy was related to overall mortality only in intermediate-risk patients (HR 2.8, CI 1.55.1, P 0.007). CV risk stratification based on myocardial stress testing is useful only in patients with just one risk factor. Screening may avoid unnecessary testing in 60 of patients...

Comparação entre o teste ergométrico e a cintilografia miocárdica na avaliação do precondicionamento isquémico precoce.; The comparison between the exercise testing and myocardial scintigraphy in the assessment of early ischemic preconditiong.

Buglia, Susimeire
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 19/04/2012 Português
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O fenômeno do precondicionamento isquêmico é definido como o aumento da tolerância à isquemia e à lesão de reperfusão, induzida por curtos e sucessivos episódios de isquemia prévios a período de isquemia prolongada. A angina do aquecimento e a de pré-infarto são duas condições clínicas relacionadas ao precondicionamento. Este fenômeno apresenta duas fases distintas, clássica ou precoce e tardia. A atenuação do infradesnível do segmento ST provocada pelo precondicionamento precoce está bem documentada, porém sua expressão cintilográfica permanece controversa. O objetivo desta pesquisa foi avaliar se as atenuações eletrocardiográficas do precondicionamento durante testes sequenciais estão associadas a modificações simultâneas das imagens de cintilografia de perfusão miocárdica em indivíduos com doença coronariana. Vinte e três pacientes foram selecionados entre março de 2009 e julho de 2011. A média de idade foi 64,5 anos (dp=7,0), 19 (82,6%) do sexo masculino e todos tinham lesão coronária em pelo menos um vaso superior a 60%. A medicação antiisquêmica foi suspensa por três a cinco dias. Os pacientes foram submetidos a três testes ergométricos a partir do exame de seleção, sendo dois deles sequenciais e o terceiro realizado após sete dias. A injeção do radiofármaco sestamibi-Tc-99m no teste de precondicionamento e contraprova foi administrado no tempo de aparecimento do infradesnível de ST de -2...

Estudo comparativo da identificacao de isquemia miocardica pela cineventriculografia contrastada sob o efeito de mononitrato de isossorbitol e pela cintilografia miocardica perfusional em portadores de cardiopatia isquemica; Comparative study for the identification of myocardial ischemia by contrast ventriculography under the effect of isosorbide mononitrate and by perfusional myocardial scintigraphy in patients with ischemic heart disease

Ludwig, Roberto Telles de Freitas; Kirschnick, Luciana Schmidt; Souza, Josiane de; Ribeiro, Leticia Weiss; Ordovas, Karen Gomes; Leitão, Cristiane Bauermann; Cruz, Rosana; Candiago, Rafael Henriques
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
Português
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Objective – To evaluate and compare the usefulness of cineventriculographies, before and after nitrate use, to technetium-99m sestamibi scintigraphy for the identification of myocardial ischemia. Methods – Twenty-six patients were studied at basal conditions and 5 minutes after intravenous administration of isosorbide mononitrate (0.3mg/kg), to evaluate the performance and regional wall motion of the left ventricle (LV). The results were compared to those obtained with technetium- 99m sestamibi scintigraphy. Results – Before nitrate, contrast ventriculography identified 30 normal segments, 62 hypokinetic segments, 28 dyskinetic segments, and 14 akinetic segments. After drug administration, 99 segments were normal, 11 hypokinetic, 11 dyskinetic, and 13 akinetic. Myocardial scintigraphy revealed 110 ischemic segments and 18 fibrotic segments (p<0.005). After drug administration, the ventriculography showed increase in the velocity of circumferential fiber shortening (p=0.0142), the ejection fraction (p=0.0462), decrease in the end-systolic volume (p=0.0031) and no change in end-diastolic volume. Conclusion – Contrast ventriculography using nitrate proved to be similar to perfusional myocardial scintigraphy in the identification of myocardial ischemia.

Comparative study for the identification of myocardial ischemia by contrast ventriculography under the effect of isosorbide mononitrate and by perfusional myocardial scintigraphy in patients with ischemic heart disease

Manfroi,Waldomiro Carlos; Ludwig,Roberto; Kirschnick,Luciana Schmidt; Souza,Josiane; Ribeiro,Letícia Weiss; Ordovás,Karen; Leitão,Cristiane; Cruz,Rosana; Candiago,Rafael
Fonte: Sociedade Brasileira de Cardiologia - SBC Publicador: Sociedade Brasileira de Cardiologia - SBC
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/1999 Português
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OBJECTIVE: To evaluate and compare the usefulness of cineventriculographies, before and after nitrate use, to technetium-99m sestamibi scintigraphy for the identification of myocardial ischemia. METHODS: Twenty-six patients were studied at basal conditions and 5 minutes after intravenous administration of isosorbide mononitrate (0.3mg/kg), to evaluate the performance and regional wall motion of the left ventricle (LV). The results were compared to those obtained with technetium-99m sestamibi scintigraphy. RESULTS: Before nitrate, contrast ventriculography identified 30 normal segments, 62 hypokinetic segments, 28 dyskinetic segments, and 14 akinetic segments. After drug administration, 99 segments were normal, 11 hypokinetic, 11 dyskinetic, and 13 akinetic. Myocardial scintigraphy revealed 110 ischemic segments and 18 fibrotic segments (p<0.005). After drug administration, the ventriculography showed increase in the velocity of circumferential fiber shortening (p=0.0142), the ejection fraction (p=0.0462), decrease in the end-systolic volume (p=0.0031) and no change in end-diastolic volume. CONCLUSION: Contrast ventriculography using nitrate proved to be similar to perfusional myocardial scintigraphy in the identification of myocardial ischemia.

Scintigraphy in postoperative follow-up of osteosynthesis of the femur with a bridge plate associated with an intramedullary pin in rabbits

Borges,N.F.; Serakides,R.; Santos,R.G.; Diniz,S.O.F.; Cardoso,V.N.; Ucros,N.S.; Torres,R.C.S.; Cardoso,S.V.; Rezende,C.M.F.
Fonte: Universidade Federal de Minas Gerais, Escola de Veterinária Publicador: Universidade Federal de Minas Gerais, Escola de Veterinária
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2013 Português
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The objective of this work was to monitor the consolidation of the femur after osteosynthesis with a bridge plate associated with the intramedullary pin using scintigraphy. We used seven New Zealand breed male rabbits, at 4 months of age, with a mean weight of 3.5 kg. We performed a three-phase bone scintigraphy with technetium-labeled methylene diphosphonate (99mTc-MDP) before and after surgery, and 20, 50 and 90 days postoperatively. The activity index (AI) was calculated by dividing the average number of uptake counts in the region of the osteotomy by the average number of counts in the corresponding region in the contralateral limb. Radiography was performed before surgery, after surgery, and 15, 30, 45, 60 and 90 days postoperatively. We found a direct relationship between the activity index and progress of bone scintigraphy in the evaluation sequence over the period of observation. Scintigraphy allows monitoring of bone metabolism and measurement of vascularization and/or bone or tissue perfusion. The images obtained in the blood pool and static phases are the most appropriate for assessing bone metabolism in the context of this study. The bridge plate associated with the intramedullary pin promotes osteosynthesis with sufficient stability to allow bone consolidation.

Comparison of relative renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured with 99mTc-DMSA static scintigraphy

Domingues,F. C.; Fujikawa,G. Y.; Decker,H.; Alonso,G.; Pereira,J. C.; Duarte,P. S.
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2006 Português
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OBJECTIVE: The aim of this study was to compare the renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured using 99mTc-DMSA static scintigraphy. METHODS: the values of relative renal function measured in 111 renal dynamic scintigraphies performed either with 99mTc-DTPA (55 studies) or with 99mTc-EC (56 studies) were compared with the relative function measured using 99mTc-DMSA static scintigraphy performed within a 1-month period. The comparisons were performed using Wilcoxon signed rank test. The number of 99mTc-DTPA and 99mTc-EC studies that presented relative renal function different by more than 5% from that measured with 99mTc-DMSA, using chi square test were also compared. RESULTS: the relative renal function measured with 99mTc-EC is not statistically different from that measured with 99mTc-DMSA (p = 0.97). The relative renal function measured with 99mTc-DTPA was statistically different from that measured using 99mTc-DMSA, but with a borderline statistical significance (p = 0.05). The number of studies with relative renal function different by more than 5% from that measured with 99mTc-DMSA is higher for the 99mTc-DTPA scintigraphy (p = 0.04) than for 99mTc-EC. CONCLUSION: the relative renal function measured with 99mTc-EC dynamic scintigraphy is comparable with that measured with 99mTc-DMSA static scintigraphy...

Effect of intertrochanteric osteotomy on the proximal femur of rabbits: assessment with power Doppler sonography and scintigraphy

Doria,Andrea S.; Cunha,Fabiano G.; Modena,Marcelo; Rodrigues,Consuelo Junqueira; Garcez,Alexandre Teles; Godoy Junior,Rui de; Bolliger Neto,Raul; Melo,Ivani Bortoleti; Buchpiguel,Carlos; Molnar,Laszlo J.; Guarniero,Roberto
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2007 Português
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OBJECTIVE: In bone injury, repair results in local increased vascularity and bone marrow remodeling. Characterizing the vascular and metabolic imaging patterns of the proximal femur following an intertrochanteric osteotomy may help clinicians decide proper management of the patient. Our objective was to measure Doppler sonography and scintigraphy interval changes in the proximal femur following intertrochanteric osteotomy and compare imaging and histomorphometric measurements in the late post-operative stage (6 weeks after surgery) in a rabbit model of bone injury. MATERIALS AND METHODS: Both hips of 12 adult rabbits were imaged with power Doppler sonography and scintigraphy prior to and after (7 days and 6 weeks) unilateral osteotomy. Accuracy of the imaging methods was evaluated using hip operative status and histomorphometric results (vascular fractional area and number of vessels per area unit) as reference standard measures. RESULTS: A significant difference in the mean number of pixels was noted between operated and non-operated femura in late post-operative power Doppler examinations (P=0.049). Although without reaching statistical significance, the AUC of Doppler measurements (AUC=0.99) was numerically greater than the AUC of scintigraphy measurements (AUC=0.857±0.099) (P=0.15) in differentiating proximal femura with regard to their fractional vascular areas in the late post-operative stage. In contrast...

99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer

Ribeiro,Monica Pires; Souza,Sergio Augusto Lopes de; Lopes,Flavia Paiva Proenca Lobo; Rosado-de-Castro,Paulo Henrique; Fonseca,Lea Mirian Barbosa da; Gutfilen,Bianca
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2013 Português
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OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively...

Validation of gastric-emptying scintigraphy of solids and liquids in mice using dedicated animal pinhole scintigraphy

Bennink, Roelof J.; de Jonge, Wouter J.; Symonds, Erin Leigh; van den Wijngaard, Rene M.; Spijkerboer, Astrid L.; Benninga, Marc A.; Boeckxstaens, Guy E.
Fonte: Soc Nuclear Medicine Publicador: Soc Nuclear Medicine
Tipo: Artigo de Revista Científica
Publicado em //2003 Português
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Gastric emptying in small laboratory animals is a useful parameter to assess gastrointestinal motility for physiologic, pharmacologic, or other research purposes. In mice, phenol red recovery is considered the gold standard for determination of gastric emptying. However, this method requires sacrifice of the animal and yields data of gastric emptying at only 1 time point. Gastric-emptying scintigraphy, the gold standard technique in humans, allows sequential and serial measurements in the same subject. In this study, we developed and validated a novel method of gastric-emptying scintigraphy applied in mice, by comparing it with phenol red photospectrometry. Methods: A dedicated animal pinhole gamma camera was equipped with a specially designed mouse application device. Gastric emptying was measured in unanesthetized mice using pinhole scintigraphy. First, gastric emptying determined with scintigraphy was compared with gastric phenol red recovery simultaneously within the same population. Subsequently, normal values for gastric emptying of solids and liquids in mice were established, and finally, the effects of handling stress and the late effects of frequently used anesthetics or sedatives on gastric emptying were assessed by scintigraphy. Results: Gastric emptying of liquids measured by pinhole scintigraphy did not significantly differ from that measured by phenol red recovery. For the same information...

Gastric emptying measurement of liquid nutrients using the 13C-octanoate breath test in critically ill patients: a comparison with scintigraphy

Nguyen, Q.; Bryant, L.; Burgstad, C.; Chapman, M.; Deane, A.; Bellon, M.; Lange, K.; Bartholomeuz, D.; Horowitz, M.; Holloway, R.; Fraser, R.
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Publicado em //2013 Português
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PURPOSE: Scintigraphy is considered the most accurate technique for the measurement of gastric emptying (GE) but, for patients in the intensive care unit, it is technically demanding, involves radiation and can interfere with care. The 13Coctanoate breath test (13C-OBT) is a simple, non-invasive technique that does not involve radiation exposure. AIM: To evaluate the performance of the 13C-OBT in the assessment of GE in critically ill patients. METHODS: The GE was assessed in 33 mechanically ventilated patients (23 M; 54.3 ± 3.0 yrs; APACHE II: 22.0 ± 1.1). Following test meal administration (100 ml Ensure_), concurrent scintigraphic measurement and breath samples (13C-OBT) were collected over 4 h. Scintigraphic meal retention was determined and the gastric emptying coefficient(GEC) and half emptying time [t50(BT)] were calculated for the 13C-OBT. Delayed GE was defined as meal retention[13 % at 180 min. RESULTS: Delayed GE was identified in 27/33 patients. Meal retention correlated modestly with t50(BT)(r = 0.55–0.66; P.001) and well with GEC (r = -0.63 to -0.74; P.0001). The strength of agreement between the two techniques was highest between GEC and retention at 120 min. The best cut-off GEC for defining delayed GE was 3.25 (AUC = 0.75; 95 % CI = 0.52–0.99; P = 0.05)...

Evaluation der 99m Tc- Knochenszintigraphie im Rahmen des prätherapeutischen Stagings oropharyngealer Karzinome; Evaluation of 99m Tc- bone scan scintigraphy in the preoperativ Staging of Malignant oral and oropharyngeal Tumors

Baghi , Mehran
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
Português
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Einleitung: Die Wertigkeit der Knochenszintigraphie wurde retrospektiv an einem Patientenkollektiv mit einem Plattenepithelkarzinom oder einem adenoidzystischen Karzinom der Mundhöhle, das zwischen 1987- 1995 in der Klinik für Mund- Kiefer- und Gesichtschirurgie des Universitätsklinikums Tübingen operativ behandelt wurde, beurteilt. Fragestellung: Es wurde untersucht, ob zwischen der planaren Knochenszintigraphie und der Lokalisation des Tumors, der Tumorgröße (pT- Klassifikation) und dem histologischen Differenzierungsgrad eine Korrelation besteht. Weiterhin wurde untersucht, ob die Indikation für eine knöcherne Resektion mittels Knochenszintigraphie gestellt werden kann. Patientengut und Methodik Insgesamt wurden 224 ( 183 männlich und 41 weiblich) untersucht. Histologisch handelte es sich bei 211 um ein Plattenepithelkarzinom und bei 13 um ein adenoizystisches Karzinom. Alle Patienten wurden präoperativ einer Ganzkörperszintigraphie unterzogen. Ergebnisse: Eine Korrelation zwischen dem planaren Knochenszintigramm und dem histologischen Differenzierungsgrad existiert nicht. Auch zwischen der Tumorgröße und dem szintigraphischen Befund konnte keine Korrelation erkannt werden, da sich herausstellte, daß bei zunehmender Tumorgröße die planare Knochenszintigraphie an Sensitivität verliert. Wegen der relativ hohen Spezifität der Knochenszintigraphie bei klinisch als T1 oder T2 eingestuften Tumoren scheint jedoch der Einsatz dieser Methode zum sicheren Ausschluß von ausgedehnten Knocheninfiltrationen geeignet. Diese diagnostische Modalität scheint jedoch bei knochennahen Tumoren nicht in der Lage zu sein...

Wertigkeit der dynamischen MRT im Vergleich zur konventionellen Radiographie, Skelettszintigraphie und statischen MRT in der Diagnostik der pedalen Osteomyelitis; Value of dynamic MRI in comparison to conventional radiography, bone scintigraphy and static MRI in the diagnosis of pedal osteomyelitis

Neukirch, Ralph
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
Português
Relevância na Pesquisa
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Einleitung: Die eindeutige Differenzierung einer pedalen Osteomyelitis gegen-über anderen Erkrankungen bei Patienten mit Diabetes mellitus und AVK und die genaue Festlegung der Infektionsgrenzen stellt für alle bildgebenden Methoden ein großes diagnostischen Problem dar. Zielsetzung: Bestimmung der Wertigkeit der dynamischen MRT im Vergleich zu konventionellem Röntgen, Drei-Phasen-Skelettszintigraphie und statischer MRT in der pedalen Osteomyelitisdiagnostik. Methodik: Diese vier Methoden wurden jeweils prospektiv an 40 Füssen bei 38 Patienten angewandt. Die Diagnosesicherung erfolgte mittels Histologie oder klinischem Verlauf. Die Kontrastmitteldynamik in der MRT wurde mit FLASH-3D-Sequenzen nach i.v. Applikation von Gd-DTPA erfasst. Anhand von Signal-intensitätszeitkurven wurde die Kontrastmittelanflutungsgeschwindigkeit in unterschiedlichen Knochenregionen und im Weichteilgewebe ermittelt. Der neu eingeführte Steigungsfaktor diente zur Ausschaltung von individuellen Durch-blutungsfaktoren. Ergebnisse: 50% der Patienten wiesen eine Osteomyelitis auf. Die Treffsicher-heit von Röntgen, Szintigraphie und statischer MRT betrug 70%, 80% und 92,5%. Szintigraphie und MRT wiesen eine Sensitivität von 90% auf. Die statische MRT zeigte eine Spezifität von 95%. Die Treffsicherheit der Kombina-tion dieser drei Verfahren betrug 90%. Die Sensitivität...

Untersuchung über die Wertigkeit der Flussmessung mittels MRT in den Nierenarterien zur Beurteilung der seitengetrennten Nierendurchblutung bei Patienten mit Nierenarterienstenose. Ein Vergleich zur Nierenfunktionsszintigraphie; Evaluation of a new MRI-method for blood flow in renal artery stenosis. Comparisons with measurements of kidney function by clearance method and by scintigraphy

Giersch, Jenny Yuhko
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
Português
Relevância na Pesquisa
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Fragestellung. Es sollte untersucht werden, inwieweit die MR-Phasenkontrast-flussmessung ohne Kontrastmittel als nicht-invasive und nicht-nephrotoxische Methode zur Beurteilung der seitengetrennten Nierendurchblutung bei Nierenarterienstenose (NAS) und zur Detektion einer NAS im Vergleich zur Nierenfunktionsszintigraphie geeignet ist. Methoden. MR-Blutflussmessung in den Nierenarterien (nMR-Fluss) bei 13 Hypertonikern mit NAS (46-71 Jahre) und 6 Hypertonikern ohne Stenose (29-63 Jahre). Bei 12 Patienten mit NAS zusätzlich Bestimmung der Technetium-99m-MAG-3-Clearance jeder Niere durch Nierenfunktionsszintigraphie ohne Captopril und Berechnung des seitengetrennten effektiven renalen Blutflusses (ERB). Korrelation von nMR-Fluss, MAG3-Clearance und ERB. Prüfung auf signifikante Unterschiede zwischen NAS-Gruppe 1 (NAS = 0-29%, n = 21), NAS-Gruppe 2 (NAS = 30-69%, n = 8) und NAS-Gruppe 3 (NAS = 70-100%, n = 6) für alle Methoden. Bestimmung der Genauigkeit von nMR-Fluss, MAG3-Clearance und ERB zur Detektion einer NAS > / = 70% mit ROC-Kurve. Vergleich zwischen Ergebnissen von Patienten, die einen ACE-Hemmer und / oder AT2-Rezeptorantagonisten eingenommen hatten, und denen von übrigen Patienten. Vergleich zwischen Ergebnissen unter Einschluss aller Patienten und nach Ausschluss von chronischer Niereninsuffizienz (CN) (n = 6 Patienten). Bestimmung von weiteren klinischen Parametern: Alter...

Skelettszintigraphische Diagnostik bei tumorösen und entzündlichen Knochenerkrankungen im Kindesalter; Bone scintigraphy - Diagnostics of tumorous and inflammatory bone diseases in childhood

Tadic, Hrvoje
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
Português
Relevância na Pesquisa
37.299194%
Ziel der vorliegenden Arbeit war es zu prüfen, inwieweit durch eine Drei-Phasen-Skelettszintigraphie anhand der Bewertung der Herdverteilung, -form, -lokalisation und Anreicherungsintensität eine Differenzierung zwischen malignen und benignen Knochentumoren und Osteomyelitiden im Kindes- und Jugendalter mit ggf. weiterer artspezifischer Aussage möglich ist. Hierbei sollte die Sensitivität im Herdnachweis, die Spezifität im Sinne einer Differential- und Artdiagnostik sowie zusätzliche Information der Drei-Phasen-Skelettszintigraphie im Vergleich zu anderen bildgebenden Verfahren und der einphasigen Skelettszintigraphie evaluiert werden. Es wurden 112 Patienten im Kindes- und Jugendalter mit der Verdachtsdiagnose eines Knochentumors oder einer Osteomyelitis einbezogen. Zur Diagnosesicherung diente bei Knochentumoren die Histologie, bei Osteomyelitiden Biopsiematerial, Blutkulturen, Bildgebung und klinischer Verlauf. Bei diesen 112 jungen Patienten wurde im Zeitraum von 1996 und 2004 in der nuklearmedizinischen Abteilung der Universitätsklinik Tübingen ein Dreiphasenskelettszintigramm durchgeführt. Die Befundausdehnung, -form, -lokalisation und Anreicherungsintensität wurden nach standardisierten Kriterien begewertet und anschließend mit der definitiven Diagnose und den Ergebnissen anderer bildgebender Verfahren verglichen. Hierbei ergab sich für den Herdnachweis eine Sensitivität von 98 %. Alle malignen Knochentumoren...

Myocardial Scintigraphy in the Evaluation of Cardiac Events in Patients without Typical Symptoms

Smanio,Paola Emanuela Poggio; Silva,Juliana Horie; Holtz,João Vitor; Ueda,Leandro; Abreu,Marilia; Marques,Carlindo; Machado,Leonardo
Fonte: Sociedade Brasileira de Cardiologia - SBC Publicador: Sociedade Brasileira de Cardiologia - SBC
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2015 Português
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AbstractBackground:Cardiovascular disease is a leading cause of death in the world and in Brazil. Myocardial scintigraphy is an important noninvasive method for detecting ischemia in symptomatic patients, but its use in asymptomatic ones or those with atypical symptoms is yet to be defined.Objective:To verify the presence of major cardiac events in asymptomatic patients or those with atypical symptoms (atypical chest pain or dyspnea) that underwent myocardial scintigraphy (MS), over a period of 8 years. Secondary objectives were to identify cardiac risk factors associated with myocardial scintigraphy abnormalities and possible predictors for major cardiac events in this group.Methods:This was a retrospective, observational study using the medical records of 892 patients that underwent myocardial scintigraphy between 2005 and 2011 and who were followed until 2013 for assessment of major cardiac events and risk factors associated with myocardial scintigraphy abnormalities. Statistical analysis was performed by Fisher’s exact test, logistic regression and Kaplan-Meyer survival curves, with statistical significance being set at p ≤ 0.05.Results:Of the total sample, 52.1% were men, 86.9% were hypertensive, 72.4% had hyperlipidemia...

Influência dos métodos de correção de atenuação na quantificação da função renal relativa em cintigrafia renal com 99mTc-DMSA; Relative renal function estimate by renal scintigraphy with 99mTc-DMSA: influence of attenuation correction methods

Amaro, Andreia; Silva, H.; Santos, A. I.; Carolino, Elisabete; Vaz, Tânia; Vieira, Lina
Fonte: Escola Superior de Tecnologia da Saúde de Lisboa Publicador: Escola Superior de Tecnologia da Saúde de Lisboa
Tipo: Artigo de Revista Científica
Publicado em /05/2015 Português
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Introdução – A estimativa da função renal relativa (FRR) através de cintigrafia renal (CR) com ácido dimercaptossuccínico marcado com tecnécio-99 metaestável (99mTc-DMSA) pode ser influenciada pela profundidade renal (PR), atendendo ao efeito de atenuação por parte dos tecidos moles que envolvem os rins. Dado que raramente é conhecida esta mesma PR, diferentes métodos de correção de atenuação (CA) foram desenvolvidos, nomeadamente os que utilizam fórmulas empíricas, como os de Raynaud, de Taylor ou de Tonnesen, ou recorrendo à aplicação direta da média geométrica (MG). Objetivos – Identificar a influência dos diferentes métodos de CA na quantificação da função renal relativa através da CR com 99mTc-DMSA e avaliar a respetiva variabilidade dos resultados de PR. Metodologia – Trinta e um pacientes com indicação para realização de CR com 99mTc-DMSA foram submetidos ao mesmo protocolo de aquisição. O processamento foi efetuado por dois operadores independentes, três vezes por exame, variando para o mesmo processamento o método de determinação da FRR: Raynaud, Taylor, Tonnesen, MG ou sem correção de atenuação (SCA). Aplicou-se o teste de Friedman para o estudo da influência dos diferentes métodos de CA e a correlação de Pearson para a associação e significância dos valores de PR com as variáveis idade...

Prospective study evaluating the relative sensitivity of 18F-NaF PET/CT for detecting skeletal metastases from renal cell carcinoma in comparison to multidetector CT and 99mTc-MDP bone scintigraphy, using an adaptive trial design

Gerety, Emma-Louise; Lawrence, Edward; Wason, James; Yan, Haixi; Hilborne, Sarah; Buscombe, John; Cheow, Heok; Shaw, Ashley; Bird, Nick; Fife, Kate; Lomas, David; Matakidou, Athena; Soloviev, Dmitry; Eisen, Tim
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Article; published version
Português
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37.299194%
This is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/annonc/mdv289; Background: The detection of occult bone metastases is a key factor in determining the management of patients with renal cell carcinoma (RCC), especially when curative surgery is considered. This prospective study assessed the sensitivity of 18F-labelled sodium fluoride in conjunction with Positron Emission Tomography/Computed Tomography (18F-NaF PET/CT) for detecting RCC bone metastases, compared to conventional imaging with bone scintigraphy or CT. Patients and methods: An adaptive 2-stage trial design was utilized, which was stopped after the first stage due to statistical efficacy. Ten patients with Stage IV RCC and bone metastases were imaged with 18F-NaF PET/CT and 99mTc-labelled methylene diphosphonate (99mTc-MDP) bone scintigraphy including pelvic Single Photon Emission Computed Tomography (SPECT). Images were reported independently by experienced radiologists and nuclear medicine physicians using a 5-point scoring system. Results: 77 lesions were diagnosed as malignant: 100% were identified by 18F-NaF PET/CT, 46% by CT and 29% by bone scintigraphy/SPECT. Standard-of-care imaging with CT and bone scintigraphy identified 65% of the metastases reported by 18F-NaF PET/CT. On an individual patient basis...

Efeito da osteotomia intertrocantérica no femur proximal de coelhos: avaliação com utra-sonografia power Doppler e cintilografia; Effect of intertrochanteric osteotomy on the proximal femur of rabbits: assessment with power Doppler sonography and scintigraphy

Doria, Andrea S.; Cunha, Fabiano G.; Modena, Marcelo; Rodrigues, Consuelo Junqueira; Garcez, Alexandre Teles; Godoy Junior, Rui de; Bolliger Neto, Raul; Melo, Ivani Bortoleti; Buchpiguel, Carlos; Molnar, Laszlo J.; Guarniero, Roberto
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 01/01/2007 Português
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37.257136%
OBJETIVO: Regeneração em casos de lesão óssea resulta em aumento da vascularização local e remodelamento da medula óssea adjacente. A caracterização imagenológica de padrões vasculares e metabólicos no fêmur proximal após uma osteotomia intertrocantérica pode auxiliar ortopedistas a decidirem qual a terapêutica mais apropriada. O objetivo deste estudo foi avaliar as alterações temporais observadas por ultra-sonografia Doppler e cintilografia no fêmur proximal após a realização de uma osteotomia intertrocantérica; e comparar achados imagenológicos e histomorfométricos no estágio pós-operatório tardio (6 semanas após a cirurgia) num modelo animal de lesão óssea. MATERIAIS AND MÉTODOS: Ambos os quadris de 12 coelhos adultos foram examinados por ultra-sonografia power Doppler e cintilografia antes e após (7 dias e 6 semanas) uma osteotomia unilateral. A acurácia dos métodos de imagem foi avaliada usando-se o status operatório dos quadris and os resultados histomorfométricos (área vascular fracional e número de vasos/unidade de área) como medidas de referência. RESULTADOS: Uma diferença significativa foi observada entre o número médio de pixels presentes no fêmur proximal operado e não-operado ao exame de power Doppler obtido no estágio pós-operatório tardio (P=0.049). Embora ser atingir significância estatística...

99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer

Ribeiro, Monica Pires; Souza, Sergio Augusto Lopes de; Lopes, Flavia Paiva Proenca Lobo; Rosado-de-Castro, Paulo Henrique; Fonseca, Lea Mirian Barbosa da; Gutfilen, Bianca
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 01/01/2013 Português
Relevância na Pesquisa
37.132317%
OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively...