Página 1 dos resultados de 326 itens digitais encontrados em 0.001 segundos

A prosody model to TTS systems

Teixeira, João Paulo
Fonte: Universidade do Porto, Faculdade de Engenharia Publicador: Universidade do Porto, Faculdade de Engenharia
Tipo: Tese de Doutorado
Português
Relevância na Pesquisa
37.447634%
This PhD thesis presents the development of a prosody system for European Portuguese (EP) for text-to-speech (TTS) applications. Basically, TTS systems carry out the automatic utterance of a text and consist in a sequence of several modules. Those modules implement the pre-processing of the text input, the phonetic transcription and the supra-segmental processing that consists in the inclusion of prosodic patterns. The prosody is responsible for a communicative intention and guarantees some naturalness in the uttered speech. The prosodic features consist in the imposition of the timing, characterized by the segmental durations and pauses, the intonation, characterized by the fundamental frequency (F0) curve, and by the intensity curve. The preparatory work that was fundamental for modelling and testing purposes is presented in the beginning. It starts with a preliminary study about the stressed syllable. This study identifies the variation range of F0, duration and intensity features in stressed syllable along contexts. Then the FEUP-IPB EP speech database that was used in following studies is presented. The database is labelled at the levels of the phoneme, word, sentence and F0. The thesis follows on with the presentation of two algorithms to provide the syllabic splitting of the text and of the phoneme sequences. This chapter ends with a proposed set of rules for the automatic phonetic transcription of the most problematic graphemes in EP. The proposed prosody model consists of several sub-models...

Evaluation of a segmental durations model for TTS

Teixeira, João Paulo; Freitas, D.
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
26.988704%
In this paper we present a condensed description of a European Portuguese segmental duration’s model for TTS purposes and concentrate on its evaluation. This model is based on artificial neural networks. The evaluation of the model quality was made by comparison with read speech. The standard deviation reached in test set is 19.5 ms and the linear correlation coefficient is 0.84. The model is perceptually evaluated with 4.12 against 4.30 for natural human read speech in a scale of 5.

Camera reading for blind people

Neto, Roberto Ferreira
Fonte: Instituto Politécnico de Leiria Publicador: Instituto Politécnico de Leiria
Tipo: Dissertação de Mestrado
Publicado em //2014 Português
Relevância na Pesquisa
26.988704%
Dissertação apresentado à Escola Superior de Tecnologia e Gestão do IPL para obtenção do grau de Mestre em Engenharia Informática - Computação Móvel, orientada pelo Doutor Nuno Fonseca.; A ausência de visão torna a vida de um invisual bastante difícil. No entanto, a utilização da tecnologia pode melhorar ligeiramente pequenos aspectos do dia-a-dia. Nesse contexto, o trabalho que se apresenta tem como objetivo a descrição do processo de desenvolvimento de uma aplicação para cegos. O projeto chama-se Camera Blind For Blind People, e tem como propósito final o desenvolvimento de uma aplicação que permita a um utilizador cego utilizar um dispositivo móvel para obter a leitura de um texto que esteja escrito numa folha de papel, num sinal, numa parede ou noutro suporte. Pretende-se com este projeto conceber o protótipo de uma aplicação para iOS, construída a partir da utilização conjunta e integrada de frameworks de reconhecimento óptico de caracteres (OCR) e de frameworks de sintetização de voz (TTS), que possibilite ao utilizador, recorrendo à câmara de um dispositivo móvel, captar uma imagem e obter a leitura do texto que exista nessa mesma imagem. O processo de reconhecimento do texto através do OCR será optimizado através da aplicação de filtros nas imagens captadas...

Organ-specific and Agamous-regulated expression and glycosylation of a pollen tube growth-promoting protein.

Cheung, A Y; Zhan, X Y; Wang, H; Wu, H M
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 30/04/1996 Português
Relevância na Pesquisa
17.946228%
Transmitting tissue-specific (TTS) protein is a pollen tube growth-promoting and attracting glycoprotein located in the stylar transmitting tissue extracellular matrix of the pistil of tobacco. The TTS protein backbones have a deduced molecular mass of about 28 kDa, whereas the glycosylated stylar TTS proteins have apparent molecular masses ranging between 50 and 100 kDa. TTS mRNAs and proteins are ectopically produced in transgenic tobacco plants that express either a cauliflower mosaic virus (CaMV) 35S promoter-TTS2 transgene or a CaMV 35S-promoter-NAG1 (NAG1 = Nicotiana tabacum Agamous gene) transgene. However, the patterns of TTS mRNA and protein accumulation and the quality of the TTS proteins produced are different in these two types of transgenic plants. In 35S-TTS transgenic plants, TTS mRNAs and proteins accumulate constitutively in vegetative and floral tissues. However, the ectopically expressed TTS proteins in these transgenic plants accumulate as underglycosylated protein species with apparent molecular masses between 30 and 50 kDa. This indicates that the capacity to produce highly glycosylated TTS proteins is restricted to the stylar transmitting tissue. In 35S-NAG transgenic plants, NAG1 mRNAs accumulate constitutively in vegetative and floral tissues...

Development and Pollination Regulated Accumulation and Glycosylation of a Stylar Transmitting Tissue-Specific Proline-Rich Protein.

Wang, H; Wu, HM; Cheung, AY
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /11/1993 Português
Relevância na Pesquisa
17.946228%
The extracellular matrix of stylar transmitting tissues of many angiosperms is enriched in secretory materials that are believed to be important for interactions with pollen tubes. We have previously characterized two related cDNAs (TTS-1 and TTS-2) for stylar transmitting tissue-specific proline-rich proteins (TTS proteins) from Nicotiana tabacum. We show here that TTS proteins are highly glycosylated proteins with apparent molecular masses ranging between 50 and 100 kD. Results from chemical and enzymatic deglycosylation suggest that TTS proteins have N-linked glycosyl groups, and the extensive glycosylation most probably has resulted from modifications at the proline residues. TTS proteins are localized to the intercellular regions between neighboring transmitting tissue cells, the space in which pollen tubes elongate as they migrate from the stigma toward the ovary. TTS mRNA and protein levels are regulated during pistil development and by pollination. The levels of TTS mRNAs and proteins increase with flower development and reach the maximal levels as flowers approach anthesis. These maximal levels are maintained in the styles for at least 3 to 4 days after pollination, during which time pollen tubes elongate and reach the ovary. Spatially...

Environmental Regulation and Virulence Attributes of the Ysa Type III Secretion System of Yersinia enterocolitica Biovar 1B

Venecia, Krista; Young, Glenn M.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /09/2005 Português
Relevância na Pesquisa
17.89266%
Pathogenic biovars of Yersinia enterocolitica maintain the well-studied plasmid-encoded Ysc type III secretion (TTS) system, which has a definitive role in virulence. Y. enterocolitica biovar 1B additionally has a distinct chromosomal locus, the Yersinia secretion apparatus pathogenicity island (YSA PI) that encodes the Ysa TTS system. The signals to which the Ysa TTS system responds and its role in virulence remain obscure. This exploratory study was conducted to define environmental cues that promote the expression of Ysa TTS genes and to define how the Ysa TTS system influences bacterium-host interactions. Using a genetic approach, a collection of Y. enterocolitica Ysa TTS mutants was generated by mutagenesis with a transposon carrying promoterless lacZYA. This approach identified genes both within and outside of the YSA PI that contribute to Ysa TTS. Expression of these genes was regulated in response to growth phase, temperature, NaCl, and pH. Additional genetic analysis demonstrated that two regulatory genes encoding components of the YsrR-YsrS (ysrS) and RcsC-YojN-RcsB (rcsB) phosphorelay systems affect the expression of YSA PI genes and each other. The collection of Ysa TTS-defective transposon mutants, along with other strains carrying defined mutations that block Ysa and Ysc TTS...

The role of alpha 2-adrenoceptors in the vasculature of the rat tail.

Redfern, W S; MacLean, M R; Clague, R U; McGrath, J C
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1995 Português
Relevância na Pesquisa
17.80758%
1. The effects of alpha 2-adrenoceptor agonists and antagonists on rat tail skin temperature (tts), an indicator of local cutaneous blood flow, were studied in conscious and anaesthetized rats and in the isolated, Krebs perfused, vascular bed of the rat tail. 2. In conscious rats, at an ambient temperature of 18.5-20 degrees C, tts was 21.0 +/- 0.2 degrees C and core (rectal) temperature (tc) was 38.2 +/- 0.04 degrees C (n = 126). The alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197; 1 mg kg-1, s.c., n = 6), produced a rapid elevation in tts to 29.1 +/- 0.7 degrees C (P < 0.001 vs. saline-treated control group), attained 10 min after injection. tc fell slightly, by 1.0 +/- 0.1 degrees C. The tts response was dose-related over the dose-range tested (0.01-1 mg kg-1, s.c.), with an ED50 of 17 micrograms kg-1, s.c. (n = 6 per dose). 3. The maximum increases in tts in response to a dose of 1 mg kg-1, s.c. of alpha 2-adrenoceptor antagonists were as follows (n = 6 per drug): delequamine (+9.6 +/- 0.8 degrees C) > yohimbine (+9.0 +/- 1.0 degrees C) > WY-26703 (+7.9 +/- 1.3 degrees C) > piperoxan (+5.6 +/- 1.7 degrees C) > idazoxan (+4.6 +/- 1.3 degrees C) > imiloxan (+4.1 +/- 1.3 degrees C) > SKF 104078 (+2.0 +/- 1.9 degrees C) > BDF-6143 (+1.3 +/- 0.8 degrees C). 4. Prazosin (0.3 mg kg-1...

A Single Gene (tts) Located outside the cap Locus Directs the Formation of Streptococcus pneumoniae Type 37 Capsular Polysaccharide: Type 37 Pneumococci Are Natural, Genetically Binary Strains

Llull, Daniel; Muñoz, Rosario; López, Rubens; García, Ernesto
Fonte: The Rockefeller University Press Publicador: The Rockefeller University Press
Tipo: Artigo de Revista Científica
Publicado em 19/07/1999 Português
Relevância na Pesquisa
27.651604%
The molecular aspects of the type 37 pneumococcal capsular biosynthesis, a homopolysaccharide composed of sophorosyl units (β-d-Glc-(1→2)-β-d-Glc) linked by β-1,3 bonds, have been studied. Remarkably, the biosynthesis of the type 37 capsule is driven by a single gene (tts) located far apart from the cap locus responsible for capsular formation in all of the types characterized to date in Streptococcus pneumoniae. However, a cap37 locus virtually identical to the cap33f cluster has been found in type 37 strains, although some of its genes are inactivated by mutations. The tts gene has been sequenced and its transcription start point determined. Tts shows sequence motifs characteristic of cellulose synthases and other β-glycosyltransferases. Insertion of the tts gene into the pneumococcal DNA causes a noticeable genome reorganization in such a way that genes normally separated by more than 350 kb in the chromosome are located together in clinical isolates of type 37. Encapsulated pneumococcal strains belonging to 10 different serotypes (or serogroups) transformed with tts synthesized type 37 polysaccharide, leading to the formation of strains that display the binary type of capsule. Type 37 pneumococcus constitutes the first case of a natural...

TtsI regulates symbiotic genes in Rhizobium species NGR234 by binding to tts boxes

Wassem, Roseli; Kobayashi, Hajime; Kambara, Kumiko; Le Quéré, Antoine; Walker, Graham C.; Broughton, William J.; Deakin, William J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
27.766892%
Infection of legumes by Rhizobium sp. NGR234 and subsequent development of nitrogen-fixing nodules are dependent on the coordinated actions of Nod factors, proteins secreted by a type III secretion system (T3SS) and modifications to surface polysaccharides. The production of these signal molecules is dependent on plant flavonoids which trigger a regulatory cascade controlled by the transcriptional activators NodD1, NodD2, SyrM2 and TtsI. TtsI is known to control the genes responsible for T3SS function and synthesis of a symbiotically important rhamnose-rich lipo-polysaccharide, most probably by binding to cis elements termed tts boxes. Eleven tts boxes were identified in the promoter regions of target genes on the symbiotic plasmid of NGR234. Expression profiles of lacZ fusions to these tts boxes showed that they are part of a TtsI-dependent regulon induced by plant-derived flavonoids. TtsI was purified and demonstrated to bind directly to two of these tts boxes. DNase I footprinting revealed that TtsI occupied not only the tts box consensus sequence, but also upstream and downstream regions in a concentration-dependent manner. Highly conserved bases of the consensus tts box were mutated and, although TtsI binding was still observed in vitro...

A Data Mining Framework for Time Series Estimation

Hu, Xiao; Xu, Peng; Wu, Shaozhi; Asgari, Shadnaz; Bergsneider, Marvin
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
17.868949%
Time series estimation techniques are usually employed in biomedical research to derive variables less accessible from a set of related and more accessible variables. These techniques are traditionally built from systems modeling approaches including simulation, blind decovolution, and state estimation. In this work, we define target time series (TTS) and its related time series (RTS) as the output and input of a time series estimation process, respectively. We then propose a novel data mining framework for time series estimation when TTS and RTS represent different sets of observed variables from the same dynamic system. This is made possible by mining a database of instances of TTS, its simultaneously recorded RTS, and the input/output dynamic models between them. The key mining strategy is to formulate a mapping function for each TTS-RTS pair in the database that translates a feature vector extracted from RTS to the dissimilarity between true TTS and its estimate from the dynamic model associated with the same TTS-RTS pair. At run time, a feature vector is extracted from an inquiry RTS and supplied to the mapping function associated with each TTS-RTS pair to calculate a dissimilarity measure. An optimal TTS-RTS pair is then selected by analyzing these dissimilarity measures. The associated input/output model of the selected TTS-RTS pair is then used to simulate the TTS given the inquiry RTS as an input. An exemplary implementation was built to address a biomedical problem of noninvasive intracranial pressure assessment. The performance of the proposed method was superior to that of a simple training-free approach of finding the optimal TTS-RTS pair by a conventional similarity-based search on RTS features.

Astringency and other oral sensations : biological sources of individual variation and association with food and beverage behaviour

Bajec, Marth R.
Fonte: Brock University Publicador: Brock University
Tipo: Electronic Thesis or Dissertation
Português
Relevância na Pesquisa
17.841005%
Orosensory perception strongly influences liking and consumption of foods and beverages. This thesis examines the influence of biological sources of individual variation on the perception of prototypical orosensory stimuli, food liking, self-reported alcohol liking and consumption, and indices of health. Two orosensory indices were examined: propylthiouracil (PROP) responsiveness, a genetically-mediated index of individual variation associated with enhanced responsiveness to orosensory stimuli often expressed as PROP taster status (PTS); and thermal taster status (TTS), a recently reported index of orosensory responsiveness. Taster status in PTS and/or TTS confers greater responsiveness to most orosensory stimuli. Gender, age, ethnicity, and fungiform papillae (FP) density were not associated with orosensory responsiveness to tastants, an astringent, and a flavour. Unlike PROP responsiveness, FP density was not associated with TTS. Both PROP responsiveness and TTS were associated with increased responsiveness to orosensory stimuli, including temperature and astringency. For PROP, this association did not hold when stimuli were presented at cold or warm temperatures...

Initial dose cascade of TTS fentanyl with proper adjuvant medications in cancer pain.

Baik, Seong Wan; Kim, Kyung Hoon; Kim, Yong Chul; Lee, Sang Chul; Kim, Dong Ki; Jung, Jae Eun
Fonte: Korean Academy of Medical Sciences Publicador: Korean Academy of Medical Sciences
Tipo: Artigo de Revista Científica
Publicado em /10/2003 Português
Relevância na Pesquisa
27.651604%
According to the three step-ladder analgesics in patients with cancer pain, adjuvant drugs are required for pain relief according to the pain character and also to reduce side effects of opioids. Pain clinicians sometimes want to decide to jump directly from naive and mild opioid to transdermal therapeutic system (TTS) fentanyl with less side effects. We investigated the safety, efficacy, and satisfaction of the patients of TTS fentanyl converting from opioid-naive and mild-opioid with adjuvant drug medications in related to dose cascade of TTS fentanyl. Both opioid-naive (n=3) and opioid-using (n=34) patients started with TTS fentanyl in the lowest available delivery rate (25 microg/hr) with rescue medication. A numeric rating scale (NRS, from 0=no pain to 10=worst pain imaginable), satisfaction of the patients with the transdermal therapy and side effects were recorded everyday during 29 days. Average reductions of NRS scores were 1.79 and 2.77, and the mean doses were 35.14 and 44.12 microg/hr on the 15th and 29th day, respectively. Reported level of satisfaction with the transdermal patch and generalized pain management were 'completely satisfied' and 'satisfied'. Frequent side effects were nausea, vomiting, and constipation. In conclusion...

Andriod Based Punjabi TTS System

Hardeep; Singh, Parminder
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Publicado em 27/06/2015 Português
Relevância na Pesquisa
27.447634%
The usage of mobile phones is nearly 3.5 times more than that of personal computers. Android has the largest share among its counter parts like IOS, Windows and Symbian Android applications have a very few restrictions on them. TTS systems on Android are available for many languages but a very few systems of this type are available for Punjabi language. Our research work had the aim to develop an application that will be able to produce synthetic Punjabi speech. The paper examines the methodology used to develop speech synthesis TTS system for the Punjabi content, which is written in Gurmukhi script. For the development of this system, we use concatenative speech synthesis method with phonemes as the basic units of concatenation. Some challenges like application size, processing time, must be considered, while porting this TTS system to resource-limited devices like mobile phones.; Comment: 5 pages,3 Figures and 1 Table Published with International Journal of Computer Science Trends and Technology (IJCST)

Unlimited Vocabulary Grapheme to Phoneme Conversion for Korean TTS

Kim, Byeongchang; Lee, WonIl; Lee, Geunbae; Lee, Jong-Hyeok
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Publicado em 10/06/1998 Português
Relevância na Pesquisa
26.988704%
This paper describes a grapheme-to-phoneme conversion method using phoneme connectivity and CCV conversion rules. The method consists of mainly four modules including morpheme normalization, phrase-break detection, morpheme to phoneme conversion and phoneme connectivity check. The morpheme normalization is to replace non-Korean symbols into standard Korean graphemes. The phrase-break detector assigns phrase breaks using part-of-speech (POS) information. In the morpheme-to-phoneme conversion module, each morpheme in the phrase is converted into phonetic patterns by looking up the morpheme phonetic pattern dictionary which contains candidate phonological changes in boundaries of the morphemes. Graphemes within a morpheme are grouped into CCV patterns and converted into phonemes by the CCV conversion rules. The phoneme connectivity table supports grammaticality checking of the adjacent two phonetic morphemes. In the experiments with a corpus of 4,973 sentences, we achieved 99.9% of the grapheme-to-phoneme conversion performance and 97.5% of the sentence conversion performance. The full Korean TTS system is now being implemented using this conversion method.; Comment: 5 pages, uses colacl.sty and acl.bst, uses epsfig. To appear in the Proceedings of the Joint 17th International Conference on Computational Linguistics 36th Annual Meeting of the Association for Computational Linguistics (COLING-ACL'98)

A Text to Speech (TTS) System with English to Punjabi Conversion

Singh, Prabhsimran; Singh, Amritpal
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Publicado em 13/11/2014 Português
Relevância na Pesquisa
26.988704%
The paper aims to show how an application can be developed that converts the English language into the Punjabi Language, and the same application can convert the Text to Speech(TTS) i.e. pronounce the text. This application can be really beneficial for those with special needs.; Comment: 5 pages, 8 figures, 3 tables

An accurate measurement of PMT TTS based on the photoelectron spectrum

Huang, W. P.; Tang, Z. B.; Li, C.; Jiang, K.; Zhao, X. K.
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
27.766892%
The water Cherenkov detector array (WCDA) for the large high altitude air shower observatory(LHAASO) will employ more than 3600 hemisphere 8 inch photomultiplier tubes (PMT). The good time performance of PMT, especially the transit time spread (TTS), is required for WCDA. TTS is usually defined as the TTS of single photoelectron, and usually determined by using single photoelectron counting technique. A method using the photoelectron spectrum is researched for the measurement of TTS. The method is appropriate for multi-photoelectrons and makes it possible to measure the TTS of different photoelectrons at the same time. The TTS of different photoelectrons is measured for Hamamatsu R5912 with the divider circuit designed in specifically. The TTS of single photoelectron is determined to 3.3 ns and satisfies the requirement of WCDA.; Comment: 5 pages, 13 figures

Aspectos neurobiológicos de la depresión en pacientes consumidores de cocaína

Rodríguez Minguela, Mª Rocío
Fonte: [Barcelona] : Universitat Autònoma de Barcelona, Publicador: [Barcelona] : Universitat Autònoma de Barcelona,
Tipo: Tesis i dissertacions electròniques; info:eu-repo/semantics/doctoralThesis; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em //2015 Português
Relevância na Pesquisa
17.89266%
Objetivo: El objetivo general es determinar si existen diferencias neurobiológicas entre la depresión mayor primaria (DMP) y la depresión mayor inducida (DI) por cocaína en pacientes con Trastorno por Dependencia de cocaína. Las posibles diferencias se estudiarán a través del estudio de la respuesta al estrés y la implicación del sistema serotonérgico. Diseño: estudio experimental aleatorizado, doble-ciego, con tres grupos de pacientes y un grupo de controles sanos. Sujetos: 54 sujetos: 20 controles sanos sin diagnóstico psiquiátrico, 15 pacientes diagnosticados de Trastorno por dependencia de cocaína y depresión mayor primaria (DSM-IV-TR), 9 pacientes diagnosticados de Trastorno por Dependencia de cocaína y depresión inducida por cocaína (DSM-IV-TR) y 10 pacientes diagnosticados de Trastorno por Dependencia de cocaína (DSM-IV-TR). Instrumentos y métodos: Selección: Diagnóstico psiquiátrico mediante PRISM, HRDS (depresión), escala de acontecimientos vitales estresantes (LSC-R), escala impulsividad de Barrat (BIS-II), STAI-E-R. Durante las sesiones experimentales: test de ansiedad-estado STAI-E y escalas analógicas visuales (tristeza, ansiedad, alerta, felicidad, molestias gástricas y mareo). Test funcionales: Test de estrés Trier Social (TTS) y Test de Depleción Aguda de Triptófano (No-TDA/TDA). Variables: - Bioquímicas: Concentraciones de cortisol y alfa-amilasa pancreática...

Asociación de Fentanilo TTS matricial + Citrato de Fentanilo Oral Transmucosa (CFOT), en pacientes que no han recibido tratamiento previo con opioides y padecen dolor crónico intenso de etiología osteoarticular: Haciendo realidad el Ascensor Analgésico

Collado,F.; Torres,L. M.
Fonte: Revista de la Sociedad Española del Dolor Publicador: Revista de la Sociedad Española del Dolor
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/05/2007 Português
Relevância na Pesquisa
37.89266%
Objetivos: Exponer los resultados obtenidos en 250 pacientes que sin haber tenido contacto previo con opioides, acceden a nuestra Unidad de Tratamiento del Dolor, padeciendo un dolor intenso (EVA ≥ 8) de más de 6 meses de evolución y afectos de un dolor de origen osteoarticular. Métodos: Estudio abierto, prospectivo y controlado. Los pacientes fueron tratados, inicialmente, con fentanilo TTS matricial de 12 µg/h + citrato de fentanilo oral transmucosa (CFOT) de 200-400 pg., para el dolor irruptivo. A los 12 días de tratamiento, se aumento la dosificación del parche matricial de fentanilo TTS, a 25 ug/h. Se valoró la situación de los pacientes mensualmente y si el dolor no estaba controlado, se aumento la dosificación de fentanilo TTS matricial. Si por el contrario, el dolor permanecía controlado durante más de un mes y no se precisaba ningún comprimido de CFOT, se redujo la dosificación del fentanilo TTS matricial. Se analizaron los registros de intensidad del dolor, calidad del descanso nocturno, efectos secundarios y consumo medio de fetanilo TTS y CFOT, obtenidos al inicio, 1º, 3º y 6º mes de tratamiento. Resultados: La EVA medio pasó del 8,86 + 0,25, inicial hasta un 2,1 + 0,74, al 6º mes. El descanso nocturno...

Patrones de uso de los opioides mayores en el dolor de origen neuropático

Ribera,Mª V.; Gálvez,R.; Vidal,M. A.
Fonte: Revista de la Sociedad Española del Dolor Publicador: Revista de la Sociedad Española del Dolor
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/05/2007 Português
Relevância na Pesquisa
27.272803%
Introducción: El dolor neuropático tiene una gran repercusión sobre los pacientes que lo padecen. Es uno de los síndromes dolorosos más complejos y su origen es diverso. Suele presentarse con una clínica de dolor quemante, pulsante, afilado, como hormigueo. que puede acompañarse de hiperalgesia o alodinia. El dolor suele presentar también alteraciones del estado de ánimo, e incluso depresión, con un gran impacto sobre la actividad social y laboral del paciente y una notable disminución de la calidad de vida. El tratamiento es difícil y, a menudo, refractario a la terapia convencional. La eficacia de los opioides ha sido controvertida aunque estudios recientes demuestran que éstos son efectivos en el tratamiento del dolor neuropático. Objetivos: Conocer los patrones de uso de los opioides mayores en el tratamiento del dolor de origen neuropático. Material y métodos: Estudio epidemiológico, transversal, descriptivo y multicéntrico realizado por 107 especialistas de Unidades de Dolor de España, en pacientes afectos de dolor neuropático. El estudio constaba de un cuestionario que recogía los datos demográficos del paciente, el motivo de la consulta, la patología base del dolor, el tiempo transcurrido desde el diagnóstico...

Anular o acortar los primeros peldaños de la Escalera Analgésica de la OMS

Rubio,A.; Muñoz,E.; Sierra,R.
Fonte: Revista de la Sociedad Española del Dolor Publicador: Revista de la Sociedad Española del Dolor
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/02/2008 Português
Relevância na Pesquisa
26.988704%
Objetivo: Consideramos la posibilidad de anular o acortar el segundo peldaño de la escalera analgésica de la OMS, con el propósito de controlar el dolor crónico de nuestros pacientes en el menor tiempo posible. Material y métodos: Presentamos un estudio sobre 74 pacientes, divididos en tres grupos, para valorar si existen diferencias entre ellos. Un primer grupo pasó a tratarse con fentanilo TTS sin tratamiento previo con opioides débiles, los otros dos se trataron anteriormente con tramadol a dosis distintas. Un grupo a dosis previas de tramadol comprendidas entre 1 y 3 mg/Kg y otro grupo con dosis comprendidas entre 3.5 y 6 mg/Kg. Resultados: Los resultados han sido similares, clínica y estadísticamente, en cuanto a efectos secundarios, control del dolor y abandonos. Conclusiones: Concluimos que es posible acortar el tiempo necesario para controlar el dolor crónico en pacientes con patologías severas y que se presuponga necesitarán la prescripción de opioides mayores y que se puede anular el primer escalón de la OMS y también acortar el segundo.