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Evaluation of the Threshold for Lung Hemorrhage by Diagnostic Ultrasound and a Proposed New Safety Index

Church, Charles C.; O’Brien, William D.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
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In a recent report (O’Brien W.D Jr, et al. “Superthreshold Behavior of…”, J Ultrasound Med 2006; 25:873–882) it was suggested that the current expression for the mechanical index (MI) was not well suited to its function of quantifying the likelihood of an adverse biological effect following exposure of the gas-filled lung to diagnostic ultrasound. The purpose of this study was to analyze the relatively large database of experimental thresholds for the induction of lung hemorrhage to: i) determine which variable(s) best describe the data, and ii) use the resulting equation to obtain a new formulation for the MI for lung exposures. Data from fourteen studies of lung hemorrhage in four common laboratory animals (mouse, rat, rabbit, pig) were tabulated with regard to five common acoustic variables: center frequency (fc), pulse repetition frequency (PRF), pulse duration (PD), exposure duration (ED), and the threshold in situ peak rarefactional pressure (pr). The thirty-four threshold data points were fit by linear regression to: i) a multiplicative model of the other variables, pr = AfcBPRFCPDDEDE, where A is a constant, ii) 14 “reduced” models in which one or more variables were not included in the analysis, iii) 4 models in which a multiplicative combination of variables has a common name e.g....

Estimation of the acoustic impedance of lung versus level of inflation for different species and ages of animals

Oelze, Michael L.; Miller, Rita J.; Blue, James P.; Zachary, James F.; O’Brien, William D.
Fonte: Acoustical Society of America Publicador: Acoustical Society of America
Tipo: Artigo de Revista Científica
Publicado em /10/2008 Português
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In a previous study, it was hypothesized that ultrasound-induced lung damage was related to the transfer of ultrasonic energy into the lungs (W. D. O’Brien et al. 2002, “Ultrasound-induced lung hemorrhage: Role of acoustic boundary conditions at the pleural surface,” J. Acoust. Soc. Am. 111, 1102–1109). From this study a technique was developed to: 1) estimate the impedance (Mrayl) of fresh, excised, ex vivo rat lung versus its level of inflation (cm H2O) and 2) predict the fraction of ultrasonic energy transmitted into the lung (M. Oelze et al. 2003, “Impedance measurements of ex vivo rat lung at different volumes of inflation.” J. Acoust. Soc. Am. 114, 3384–3393). In the current study, the same technique was used to estimate the frequency-dependent impedance of lungs from rats, rabbits, and pigs of various ages. Impedance values were estimated from lungs under deflation (atmospheric pressure, 0 cm H2O) and three volumes of inflation pressure [7 cm H2O (5 cm H2O for pigs), 10 cm H2O, and 15 cm H2O]. Lungs were scanned in a tank of degassed 37 °C water. The frequency-dependent acoustic pressure reflection coefficient was determined over a frequency range of 3.5–10 MHz. From the reflection coefficient, the frequency-dependent lung impedance was calculated with values ranging from an average of 1.4 Mrayl in deflated lungs (atmospheric pressure) to 0.1 Mrayl for fully inflated lungs (15 cm H2O). Across all species...

Synthesis of Aryl-Heteroaryl Ureas (AHUs) Based on 4-Aminoquinoline and Their Evaluation Against the Insulin-Like Growth Factor Receptor (IGF-1R)

Engen, William; O’Brien, Terrence E.; Kelly, Brendan; Do, Jacinda; Rillera, Liezel; Stapleton, Lance; Youngren, Jack F.; Anderson, Marc O.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
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The insulin-like growth factor receptor (IGF-1R) is a receptor tyrosine kinase (RTK) involved in all stages of the development and propagation of breast and other cancers. The inhibition of IGF-1R by small molecules remains a promising strategy to treat cancer. Herein, we explore SAR around previously characterized lead compound (1), which is an aryl-heteroaryl urea (AHU) consisting of 4-aminoquinaldine and a substituted aromatic ring system. A library of novel AHU compounds was prepared based on derivatives of the 4-aminoquinoline heterocycle (including various 2-substituted derivatives, and naphthyridines). The compounds were screened for in vitro inhibitory activity against IGF-1R, and several compounds with improved activity (3-5 μM) were identified. Furthermore, a computational docking study was performed, which identifies a fairly consistent lowest energy mode of binding for the more-active set of inhibitors in this series, while the less-active inhibitors do not adopt a consistent mode of binding.

Extended three-dimensional impedance map methods for identifying ultrasonic scattering sites

Mamou, Jonathan; Oelze, Michael L.; O’Brien, William D.; Zachary, James F.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /02/2008 Português
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The frequency-dependent ultrasound backscatter from tissues contains information about the microstructure that can be quantified. In many cases, the anatomic microstructure details responsible for ultrasonic scattering remain unidentified. However, their identification would lead to potentially improved methodologies for characterizing tissue and diagnosing disease from ultrasonic backscatter measurements. Recently, three-dimensional (3D) acoustic models of tissue microstructure, termed 3D impedance maps (3DZMs), were introduced to help to identify scattering sources [J. Mamou, M. L. Oelze, W. D. O’Brien, Jr., and J. F. Zachary, “Identifying ultrasonic scattering sites from 3D impedance maps,” J. Acoust. Soc. Am. 117, 413–423 (2005)]. In the current study, new 3DZM methodologies are used to model and identify scattering structures. New processing procedures (e.g., registration, interpolations) are presented that allow more accurate 3DZMs to be constructed from histology. New strategies are proposed to construct scattering models [i.e., form factor (FF)] from 3DZMs. These new methods are tested on simulated 3DZMs, and then used to evaluate 3DZMs from three different rodent tumor models. Simulation results demonstrate the ability of the extended strategies to accurately predict FFs and estimate scatterer properties. Using the 3DZM methods...

Analysis of outcomes in adolescents and young adults with chronic myelogenous leukemia treated with upfront tyrosine kinase inhibitor therapy

Pemmaraju, Naveen; Kantarjian, Hagop; Shan, Jianqin; Jabbour, Elias; Quintas-Cardama, Alfonso; Verstovsek, Srdan; Ravandi, Farhad; Wierda, William; O’Brien, Susan; Cortes, Jorge
Fonte: Ferrata Storti Foundation Publicador: Ferrata Storti Foundation
Tipo: Artigo de Revista Científica
Publicado em /07/2012 Português
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Bistability of seizure-like bursting and silence

Barnett, William; O’Brien, Gabrielle; Cymbalyuk, Gennady S
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 16/07/2012 Português
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Lipid-Protein Interactions in Plasma Membranes of Fiber Cells Isolated from the Human Eye Lens

Raguz, Marija; Mainali, Laxman; O’Brien, William J.; Subczynski, Witold K.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
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The protein content in human lens membranes is extremely high, increases with age, and is higher in the nucleus as compared with the cortex, which should strongly affect the organization and properties of the lipid bilayer portion of intact membranes. To assess these effects, the intact cortical and nuclear fiber cell plasma membranes isolated from human lenses from 41- to 60-year-old donors were studied using electron paramagnetic resonance spin-labeling methods. Results were compared with those obtained for lens lipid membranes prepared from total lipid extracts from human eyes of the same age group [Mainali,L., Raguz, M., O’Brien, W. J., and Subczynski, W. K. (2013) Biochim. Biophys. Acta]. Differences were considered to be mainly due to the effect of membrane proteins. The lipid-bilayer portions of intact membranes were significantly less fluid than lipid bilayers of lens lipid membranes, prepared without proteins. The intact membranes were found to contain three distinct lipid environments termed the bulk lipid domain, boundary lipid domain, and trapped lipid domain. However, the cholesterol bilayer domain, which was detected in cortical and nuclear lens lipid membranes, was not detected in intact membranes. The relative amounts of bulk and trapped lipids were evaluated. The amount of lipids in domains uniquely formed due to the presence of membrane proteins was greater in nuclear membranes than in cortical membranes. Thus...

Phase I-II Clinical Trial of Oxaliplatin, Fludarabine, Cytarabine, and Rituximab Therapy in Aggressive, Relapsed/Refractory Chronic Lymphocytic Leukemia or Richter’s Syndrome

Tsimberidou, Apostolia M.; Wierda, William G.; Wen, Sijin; Plunkett, William; O’Brien, Susan; Kipps, Thomas J.; Jones, Jeffrey A.; Badoux, Xavier; Kantarjian, Hagop; Keating, Michael J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
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Mesozoic origin for West Indian insectivores

Roca, Alfred L.; Bar-Gal, Gila K.; Elzirik, Eduardo; Helgen, Kristofer Michael; Maria, Roberto; Springer, Mark S.; O'Brien, Stephen J.; Murphy, William J.
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Publicado em //2004 Português
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Alfred L. Roca, Gila Kahila Bar-Gal, Eduardo Eizirik, Kristofer M. Helgen, Roberto Maria, Mark S. Springer, Stephen J. O'Brien & William J. Murphy

The social responsibility reporting practices of Australian global firms and how these practices enhance economic success

Mangos, Nicholas Constantine; O'Brien, Peter William
Fonte: ISBEE Publicador: ISBEE
Tipo: Conference paper
Publicado em //2000 Português
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N.C. Mangos, P.W. O'Brien

Victorian carbon dioxide geological storage options; an engineering evaluation of storage potential in southeastern Australia

O'Brien, Geoffrey William; Gunn, Robert; Raistrick, Mark; Buffin, Andrew; Tingate, Peter Richard; Miranda, John; Arian, Natt
Fonte: Elsevier BV Publicador: Elsevier BV
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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Geoffrey O’Brien, Robert Gunn, Mark Raistrick, Andrew Buffin, Peter Tingate, John Miranda and Natt Arian

Shopping for Computer Restaurant Management Systems

O'Brien, William G.
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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A myriad of computer management systems are available for the restaurant business. The author discusses all aspects of evaluating, purchasing, and using such systems for a restaurant operation.

Near Term Computer Management Strategy For Hospitality Managers and Computer System Vendors

O'Brien, William G.
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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In his dialogue - Near Term Computer Management Strategy For Hospitality Managers and Computer System Vendors - by William O'Brien, Associate Professor, School of Hospitality Management at Florida International University, Associate Professor O’Brien initially states: “The computer revolution has only just begun. Rapid improvement in hardware will continue into the foreseeable future; over the last five years it has set the stage for more significant improvements in software technology still to come. John Naisbitt's information electronics economy¹ based on the creation and distribution of information has already arrived and as computer devices improve, hospitality managers will increasingly do at least a portion of their work with software tools.” At the time of this writing Assistant Professor O’Brien will have you know, contrary to what some people might think, the computer revolution is not over, it’s just beginning; it’s just an embryo. Computer technology will only continue to develop and expand, says O’Brien with citation. “A complacent few of us who feel “we have survived the computer revolution” will miss opportunities as a new wave of technology moves through the hospitality industry,” says ‘Professor O’Brien. “Both managers who buy technology and vendors who sell it can profit from strategy based on understanding the wave of technological innovation...

File Control: The Heart Of Business Computer Management

O'Brien, William G.
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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In his study - File Control: The Heart Of Business Computer Management - William G. O'Brien, Assistant Professor, The School of Hospitality Management at Florida International University, initially informs you: “Even though computers are an everyday part of the hospitality industry, many managers lack the knowledge and experience to control and protect the files in these systems. The author offers guidelines which can minimize or prevent damage to the business as a whole.” Our author initially opens this study with some anecdotal instances illustrating the failure of hospitality managers to exercise due caution with regard to computer supported information systems inside their restaurants and hotels. “Of the three components that make up any business computer system (data files, programs, and hard-ware), it is files that are most important, perhaps irreplaceable, to the business,” O’Brien informs you. O’Brien breaks down the noun, files, into two distinct categories. They are, the files of extrinsic value, and its counterpart the files of intrinsic value. An example of extrinsic value files would be a restaurant’s wine inventory. “As sales are made and new shipments are received, the computer updates the file,” says O’Brien. “This information might come directly from a point-of-sale terminal or might be entered manually by an employee...

Database As A Tool For Hospitality Management

O'Brien, William G.
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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In his discussion - Database As A Tool For Hospitality Management - William O'Brien, Assistant Professor, School of Hospitality Management at Florida International University, O’Brien offers at the outset, “Database systems offer sweeping possibilities for better management of information in the hospitality industry. The author discusses what such systems are capable of accomplishing.” The author opens with a bit of background on database system development, which also lends an impression as to the complexion of the rest of the article; uh, it’s a shade technical. “In early 1981, Ashton-Tate introduced dBase 11. It was the first microcomputer database management processor to offer relational capabilities and a user-friendly query system combined with a fast, convenient report writer,” O’Brien informs. “When 16-bit microcomputers such as the IBM PC series were introduced late the following year, more powerful database products followed: dBase 111, Friday!, and Framework. The effect on the entire business community, and the hospitality industry in particular, has been remarkable”, he further offers with his informed outlook. Professor O’Brien offers a few anecdotal situations to illustrate how much a comprehensive data-base system means to a hospitality operation...

Database System for Alumni Tracking

Moll, Steven V.
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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In their discussion - Database System for Alumni Tracking - by Steven Moll, Associate Professor and William O'Brien, Assistant Professor, School of Hospitality Management at Florida International University, Professors Moll and O’Brien initially state: “The authors describe a unique database program which was created to solve problems associated with tracking hospitality majors subsequent to graduation.” “…and please, whatever you do, keep in touch with your school; join an alum’ organization. It is a great way to engage the resources of your school to help further your career,” says Professor Claudia Castillo in addressing a group of students attending her Life after College seminar on 9/18/2009. This is a very good point and it is obviously germane to the article at hand. “One of the greatest strengths of a hospitality management school, a strength that grows with each passing year, is its body of alumni,” say the authors. “Whether in recruiting new students or placing graduates, whether in fund raising or finding scholarship recipients, whatever the task, the network of loyal alumni stands ready to help.” The caveat is the resources are only available if students and school, faculty and alumni can keep track of each other...

Hospitality Research: How to Plan, Fund, Execute, and Publish

Kopenhaver, Lendal H.; O'Brien, William
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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Researchers interested in exploring topics of concern to the hospitality industry can discover a wide range of areas to be explored and a variety of sources to fund the research. The authors discuss a four-step plan for conducting and publishing quality research, including tips for the writing process.

An Analysis of Contributors to the FIU Hospitality Review: Volume 1 to Volume 19

O'Brien, William G.; Moncarz, Elisa S.
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
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This article documents all major articles in the FIU Hospitality Review, from its inaugural issue in spring of 1983 through 2001; 346 articles and 325 authors from 127 affiliations are included, as well as the academic institutions, hospitality industry organizations and authors who have contributed most frequently. The high ranking received by the FIU Hospitality Review is evidence of the many researchers and industry executives who have contributed over the past two decades.

Modulating influence on HIV/AIDS by interacting RANTES gene variants

An, Ping; Nelson, George W.; Wang, Lihua; Donfield, Sharyne; Goedert, James J.; Phair, John; Vlahov, David; Buchbinder, Susan; Farrar, William L.; Modi, William; O'Brien, Stephen J.; Winkler, Cheryl A.
Fonte: The National Academy of Sciences Publicador: The National Academy of Sciences
Tipo: Artigo de Revista Científica
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RANTES (regulated on activation normal T cell expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replication in vitro. We tested the influence of four RANTES single nucleotide polymorphism (SNP) variants and their haplotypes on HIV-1 infection and AIDS progression in five AIDS cohorts. Three SNPs in the RANTES gene region on chromosome 17 (403A in the promoter, In1.1C in the first intron, and 3′222C in the 3′ untranslated region) are associated with increased frequency of HIV-1 infection. The common In1.1C SNP allele is nested within an intronic regulatory sequence element that exhibits differential allele binding to nuclear proteins and a down-regulation of gene transcription. The In1.1C allele or haplotypes that include In1.1C display a strong dominant association with rapid progression to AIDS among HIV-1-infected individuals in African-American, European-American, and combined cohorts. The principal RANTES SNP genetic influence on AIDS progression derives from the down-regulating RANTES In1.1C allele, although linkage disequilibrium with adjoining RANTES SNPs including a weaker up-regulating RANTES promoter allele (−28G), can modify the observed epidemiological patterns. The In1.1C-bearing genotypes account for 37% of the attributable risk for rapid progression among African Americans and may also be an important influence on AIDS progression in Africa. The diminished transcription of RANTES afforded by the In1.1C regulatory allele is consistent with increased HIV-1 spread in vivo...

Reporter; RIT Reporter; Reporter Magazine

Sutherland, James
Fonte: Rochester Institute of Technology Publicador: Rochester Institute of Technology
Tipo: Magazine
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Keynote Speakers (pg. 3); Schedule of Events (day) (pg. 4); Rehearse for the Apocalypse (pg. 6); Evening Schedule (pg. 7); Ballantine’s Handbook is the Best (pg. 7); RIT Reporter, Rochester Institute of Technology. Publishers: Dean Dexter, Neil Shapiro. General Chairmen: Skip Blumenthal, Bernadette Curran, Deb Cross. Editor: James Sutherland. Assistant Editors: Judy Brown, Patti Paul. Business: Todd Carol. Photographer: Steve Neumann. Art Director: Richard Ronchi. Production: James Rubright, Meredith Gould. Advisor: Thomas O'Brien. Speakers: John Moore. Films: Martin Cohen, Charlie Winfree, Bernadette Curran. Workshops: Skip Blumenthal, Tom Lynch, Barry Strom, William DeRitter. Water Testing Committee: Barry Strom. General Advisor: William Gibson.